Subject(s)
Maxillary Diseases/surgery , Natural Orifice Endoscopic Surgery/methods , Odontogenic Cysts/surgery , Otorhinolaryngologic Surgical Procedures/methods , Humans , Maxillary Diseases/diagnostic imaging , Maxillary Diseases/pathology , Odontogenic Cysts/diagnostic imaging , Odontogenic Cysts/pathology , Retrospective Studies , Tomography, X-Ray ComputedABSTRACT
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targets which remain to be exploited for better therapeutic outcome. The present review discusses on the pathophysiology of cerebral malaria with particular emphasis on scope and promises of curcumin as an adjunctive therapy to improve survival and overcome neurological deficits.
Subject(s)
Humans , Adjuvants, Pharmaceutic/administration & dosage , Antimalarials/administration & dosage , Curcumin/administration & dosage , Malaria, Cerebral/drug therapyABSTRACT
Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targets which remain to be exploited for better therapeutic outcome. The present review discusses on the pathophysiology of cerebral malaria with particular emphasis on scope and promises of curcumin as an adjunctive therapy to improve survival and overcome neurological deficits.