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1.
Bone Joint J ; 99-B(2): 199-203, 2017 Feb.
Article in English | MEDLINE | ID: mdl-28148661

ABSTRACT

AIMS: We present the clinical and radiological results at a minimum follow-up of five years for patients who have undergone multiple cement-in-cement revisions of their femoral component at revision total hip arthroplasty (THA). PATIENTS AND METHODS: We reviewed the outcome on a consecutive series of 24 patients (10 men, 14 women) (51 procedures) who underwent more than one cement-in-cement revision of the same femoral component. The mean age of the patients was 67.5 years (36 to 92) at final follow-up. Function was assessed using the original Harris hip score (HHS), Oxford Hip Score (OHS) and the Merle D'Aubigné Postel score (MDP). RESULTS: The mean length of follow-up was 81.7 months (64 to 240). A total of 41 isolated acetabular revisions were performed in which stem removal facilitated access to the acetabulum, six revisions were conducted for loosening of both components and two were isolated stem revisions (each of these patients had undergone at least two revisions). There was significant improvement in the OHS (p = 0.041), HHS (p = 0.019) and MDP (p = 0.042) scores at final follow-up There were no stem revisions for aseptic loosening. Survival of the femoral component was 91.9% (95% confidence intervals (CI) 71.5 to 97.9) at five years and 91.7% (95% CI 70 to 97) at ten years (number at risk 13), with stem revision for all causes as the endpoint. CONCLUSION: Cement-in-cement revision is a viable technique for performing multiple revisions of the well cemented femoral component during revision total hip arthroplasty at a minimum of five years follow-up. Cite this article: Bone Joint J 2017;99-B:199-203.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Femur/surgery , Hip Joint/surgery , Adult , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/adverse effects , Cementation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Prosthesis Failure , Reoperation , Retrospective Studies , Treatment Outcome
2.
Bone Joint J ; 98-B(3): 410-3, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26920968

ABSTRACT

AIMS: Our aim, using English Hospital Episode Statistics data before during and after the Distal Radius Acute Fracture Fixation Trial (DRAFFT), was to assess whether the results of the trial affected clinical practice. PATIENTS AND METHODS: Data were grouped into six month intervals from July 2005 to December 2014. All patient episodes in the National Health Service involving emergency surgery for an isolated distal radial fracture were included. RESULTS: Clinical practice in England had not changed in the five years before DRAFFT: 75% of patients were treated with plate fixation versus 12% with Kirschner (K)-wires. After the publication of the trial, the proportion of patients having K-wire fixation rose to 42% with a concurrent fall in the proportion having fixation with a plate to 48%. The proportion of 'other' procedures stayed the same. TAKE HOME MESSAGE: It appears that surgeons in the United Kingdom do change their practice in response to large, pragmatic, multicentre clinical trials in musculoskeletal trauma.


Subject(s)
Diffusion of Innovation , Fracture Fixation, Internal/trends , Professional Practice/trends , Radius Fractures/surgery , Bone Plates , Bone Wires , England , Fracture Fixation, Internal/instrumentation , Fracture Fixation, Internal/methods , Fracture Fixation, Internal/statistics & numerical data , Health Services Research/methods , Humans , Pragmatic Clinical Trials as Topic , Professional Practice/statistics & numerical data , Randomized Controlled Trials as Topic , Wrist Injuries/surgery
3.
Eur J Orthop Surg Traumatol ; 25(4): 655-60, 2015 May.
Article in English | MEDLINE | ID: mdl-25260576

ABSTRACT

Cemented Thompson's prostheses have been used to treat elderly patients with displaced intracapsular hip fractures at our two units for the last 15 years, amid growing support for the use of newer implant designs for hip hemiarthroplasty. This provided us with an opportunity to investigate survival of the Thompson's stem in our patients. A retrospective cohort study was set up to review previously collected data on patients who underwent Thompson's hemiarthroplasty over a 7-year period. These were linked to surgical notes, clinical letters and radiographs to record post-operative course and subsequent admissions and procedures. The identifiers were then linked to mortality data from the Office of 'National Statistics. Kaplan-Meier survival analyses were done for implants and patients. A total of 1,632 patients (mean age 82.7 years) underwent 1,670 procedures. Five-year implant survival was 95.4 %. A total of 36 stems were revised, including 14 revisions to total hip arthroplasty and 22 excision arthroplasties. Reasons for revision included infection (2.1 %), dislocation (1.1 %) and aseptic loosening (0.5 %). Symptomatic aseptic loosening and acetabular erosion occurred late (mean time 3.2 and 5.7 years, respectively following surgery). Aseptic loosening and erosion following hemiarthroplasty are relatively late complications.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Bone Cements/therapeutic use , Femoral Neck Fractures/surgery , Hemiarthroplasty/methods , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/mortality , Femoral Neck Fractures/diagnostic imaging , Femoral Neck Fractures/mortality , Hemiarthroplasty/mortality , Hip Prosthesis , Humans , Kaplan-Meier Estimate , Middle Aged , Prosthesis Failure , Prosthesis-Related Infections/diagnostic imaging , Prosthesis-Related Infections/mortality , Radiography , Reoperation/mortality , Retrospective Studies
4.
Bone Joint Res ; 3(5): 146-9, 2014 May.
Article in English | MEDLINE | ID: mdl-24837005

ABSTRACT

The National Institute for Health and Clinical Excellence (NICE) has thus far relied on historical data and predominantly industry-sponsored trials to provide evidence for venous thromboembolic (VTE) prophylaxis in joint replacement patients. We argue that the NICE guidelines may be reliant on assumptions that are in need of revision. Following the publication of large scale, independent observational studies showing little difference between low-molecular-weight heparins and aspirin, and recent changes to the guidance provided by other international bodies, should NICE reconsider their recommendations? Cite this article: Bone Joint Res 2014;3:146-9.

5.
Bone Joint J ; 95-B(11): 1556-61, 2013 Nov.
Article in English | MEDLINE | ID: mdl-24151279

ABSTRACT

In our department we use an enhanced recovery protocol for joint replacement of the lower limb. This incorporates the use of intravenous tranexamic acid (IVTA; 15 mg/kg) at the induction of anaesthesia. Recently there was a national shortage of IVTA for 18 weeks; during this period all patients received an oral preparation of tranexamic acid (OTA; 25 mg/kg). This retrospective study compares the safety (surgical and medical complications) and efficacy (reduction of transfusion requirements) of OTA and IVTA. During the study period a total of 2698 patients received IVTA and 302 received OTA. After adjusting for a range of patient and surgical factors, the odds ratio (OR) of receiving a blood transfusion was significantly higher with IVTA than with OTA (OR 0.48 (95% confidence interval 0.26 to 0.89), p = 0.019), whereas the safety profile was similar, based on length of stay, rate of readmission, return to theatre, deep infection, stroke, gastrointestinal bleeding, myocardial infarction, pneumonia, deep-vein thrombosis and pulmonary embolism. The financial benefit of OTA is £2.04 for a 70 kg patient; this is amplified when the cost saving associated with significantly fewer blood transfusions is considered. Although the number of patients in the study is modest, this work supports the use of OTA, and we recommend that a randomised trial be undertaken to compare the different methods of administering tranexamic acid.


Subject(s)
Antifibrinolytic Agents/administration & dosage , Arthroplasty, Replacement, Hip/rehabilitation , Arthroplasty, Replacement, Knee/rehabilitation , Recovery of Function/drug effects , Tranexamic Acid/administration & dosage , Administration, Intravenous , Administration, Oral , Adult , Aged , Aged, 80 and over , Antifibrinolytic Agents/adverse effects , Antifibrinolytic Agents/therapeutic use , Blood Transfusion , Female , Humans , Length of Stay , Male , Middle Aged , Postoperative Complications/prevention & control , Retrospective Studies , Tranexamic Acid/adverse effects , Tranexamic Acid/therapeutic use , Treatment Outcome
6.
Bone Joint J ; 95-B(10): 1359-65, 2013 Oct.
Article in English | MEDLINE | ID: mdl-24078532

ABSTRACT

Pre-operative variables are increasingly being used to determine eligibility for total knee replacement (TKR). This study was undertaken to evaluate the relationships, interactions and predictive capacity of variables available pre- and post-operatively on patient satisfaction following TKR. Using nationally collected patient reported outcome measures and data from the National Joint Registry for England and Wales, we identified 22 798 patients who underwent TKR for osteoarthritis between August 2008 and September 2010. The ability of specific covariates to predict satisfaction was assessed using ordinal logistic regression and structural equational modelling. Only 4959 (22%) of 22 278 patients rated the results of their TKR as 'excellent', despite the majority (71%, n = 15 882) perceiving their knee symptoms to be much improved. The strongest predictors of satisfaction were post-operative variables. Satisfaction was significantly and positively related to the perception of symptom improvement (operative success) and the post-operative EuroQol-5D score. While also significant within the models pre-operative variables were less important and had a minimal influence upon post-operative satisfaction. The most robust predictions of satisfaction occurred only when both pre- and post-operative variables were considered together. These findings question the appropriateness of restricting access to care based on arbitrary pre-operative thresholds as these factors have little bearing on post-operative satisfaction.


Subject(s)
Arthroplasty, Replacement, Knee/standards , Patient Satisfaction , Aged , Arthroplasty, Replacement, Knee/methods , Arthroplasty, Replacement, Knee/rehabilitation , Cohort Studies , England , Female , Humans , Male , Middle Aged , Osteoarthritis, Knee/surgery , Preoperative Care/methods , Prognosis , Quality of Life , Registries , Retrospective Studies , Severity of Illness Index , Treatment Outcome , Wales
7.
Bone Joint J ; 95-B(6): 747-57, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23723267

ABSTRACT

The popularity of cementless total hip replacement (THR) has surpassed cemented THR in England and Wales. This retrospective cohort study records survival time to revision following primary cementless THR with the most common combination (accounting for almost a third of all cementless THRs), and explores risk factors independently associated with failure, using data from the National Joint Registry for England and Wales. Patients with osteoarthritis who had a DePuy Corail/Pinnacle THR implanted between the establishment of the registry in 2003 and 31 December 2010 were included within analyses. There were 35 386 procedures. Cox proportional hazard models were used to analyse the extent to which the risk of revision was related to patient, surgeon and implant covariates. The overall rate of revision at five years was 2.4% (99% confidence interval 2.02 to 2.79). In the final adjusted model, we found that the risk of revision was significantly higher in patients receiving metal-on-metal (MoM: hazard ratio (HR) 1.93, p < 0.001) and ceramic-on-ceramic bearings (CoC: HR 1.55, p = 0.003) compared with the best performing bearing (metal-on-polyethylene). The risk of revision was also greater for smaller femoral stems (sizes 8 to 10: HR 1.82, p < 0.001) compared with mid-range sizes. In a secondary analysis of only patients where body mass index (BMI) data were available (n = 17 166), BMI ≥ 30 kg/m(2) significantly increased the risk of revision (HR 1.55, p = 0.002). The influence of the bearing on the risk of revision remained significant (MoM: HR 2.19, p < 0.001; CoC: HR 2.09, p = 0.001). The risk of revision was independent of age, gender, head size and offset, shell, liner and stem type, and surgeon characteristics. We found significant differences in failure between bearing surfaces and femoral stem size after adjustment for a range of covariates in a large cohort of single-brand cementless THRs. In this study of procedures performed since 2003, hard bearings had significantly higher rates of revision, but we found no evidence that head size had an effect. Patient characteristics, such as BMI and American Society of Anesthesiologists grade, also influence the survival of cementless components.


Subject(s)
Arthroplasty, Replacement, Hip , Osteoarthritis, Hip/surgery , Risk Assessment/methods , Aged , England , Female , Follow-Up Studies , Humans , Male , Middle Aged , Prognosis , Prosthesis Design , Prosthesis Failure , Reoperation/statistics & numerical data , Retrospective Studies , Risk Factors , Wales
8.
Bone Joint Res ; 2(3): 58-65, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23610703

ABSTRACT

OBJECTIVES: To review the current best surgical practice and detail a multi-disciplinary approach that could further reduce joint replacement infection. METHODS: Review of relevant literature indexed in PubMed. RESULTS: Surgical site infection is a major complication following arthroplasty. Despite its rarity in contemporary orthopaedic practice, it remains difficult to treat and is costly in terms of both patient morbidity and long-term health care resources. CONCLUSIONS: Emphasis on education of patients and all members of the health-care team and raising awareness in how to participate in preventative efforts is imperative.

9.
J Bone Joint Surg Br ; 94(12): 1611-7, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23188900

ABSTRACT

Despite excellent results, the use of cemented total hip replacement (THR) is declining. This retrospective cohort study records survival time to revision following primary cemented THR using the most common combination of components that accounted for almost a quarter of all cemented THRs, exploring risk factors independently associated with failure. All patients with osteoarthritis who had an Exeter V40/Contemporary THR (Stryker) implanted before 31 December 2010 and recorded in the National Joint Registry for England and Wales were included in the analysis. Cox's proportional hazard models were used to analyse the extent to which risk of revision was related to patient, surgeon and implant covariates, with a significance threshold of p < 0.01. A total of 34 721 THRs were included in the study. The overall seven-year rate of revision for any reason was 1.70% (99% confidence interval (CI) 1.28 to 2.12). In the final adjusted model the risk of revision was significantly higher in THRs with the Contemporary hooded component (hazard ratio (HR) 1.88, p < 0.001) than with the flanged version, and in smaller head sizes (< 28 mm) compared with 28 mm diameter heads (HR 1.50, p = 0.005). The seven-year revision rate was 1.16% (99% CI 0.69 to 1.63) with a 28 mm diameter head and flanged component. The overall risk of revision was independent of age, gender, American Society of Anesthesiologists grade, body mass index, surgeon volume, surgical approach, brand of cement/presence of antibiotic, femoral head material (stainless steel/alumina) and stem taper size/offset. However, the risk of revision for dislocation was significantly higher with a 'plus' offset head (HR 2.05, p = 0.003) and a hooded acetabular component (HR 2.34, p < 0.001). In summary, we found that there were significant differences in failure between different designs of acetabular component and sizes of femoral head after adjustment for a range of covariates.


Subject(s)
Acetabulum/surgery , Arthroplasty, Replacement, Hip/methods , Bone Cements/therapeutic use , Femur Head/surgery , Osteoarthritis, Hip/surgery , Adult , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/adverse effects , Bone Cements/adverse effects , England , Female , Hip Prosthesis , Humans , Male , Middle Aged , Prosthesis Design , Prosthesis Failure , Registries , Reoperation , Retrospective Studies , Risk Factors , Treatment Outcome , Wales
10.
J Bone Joint Surg Br ; 94(12): 1641-8, 2012 Dec.
Article in English | MEDLINE | ID: mdl-23188905

ABSTRACT

Current analysis of unicondylar knee replacements (UKRs) by national registries is based on the pooled results of medial and lateral implants. Consequently, little is known about the differential performance of medial and lateral replacements and the influence of each implant type within these pooled analyses. Using data from the National Joint Registry for England and Wales (NJR) we aimed to determine the proportion of UKRs implanted on the lateral side of the knee, and their survival and reason for failure compared with medial UKRs. By combining information on the side of operation with component details held on the NJR, we were able to determine implant laterality (medial versus lateral) for 32 847 of the 35 624 unicondylar replacements (92%) registered before December 2010. Of these, 2052 (6%) were inserted on the lateral side of the knee. The rates of survival at five years were 93.1% (95% confidence interval (CI) 92.7 to 93.5) for medial and 93.0% (95% CI 91.1 to 94.9) for lateral UKRs (p = 0.49). The rates of failure remained equivalent after adjusting for patient age, gender, American Society of Anesthesiologists (ASA) grade, indication for surgery and implant design using Cox's proportional hazards method (hazard ratio for lateral relative to medial replacement = 0.88 (95% CI 0.69 to 1.13); p = 0.32). Aseptic loosening/lysis and unexplained pain were the main reasons for revision in both groups, although the reasons did vary depending on whether a mobile- or a fixed-bearing design was used. At a maximum of eight years the mid-term survival rates of medial and lateral UKRs are similar.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Knee Joint/surgery , Prosthesis Failure/etiology , Adult , Aged , Aged, 80 and over , Arthroplasty, Replacement, Knee/adverse effects , England , Female , Humans , Knee Prosthesis , Male , Middle Aged , Registries , Reoperation , Survival Analysis , Wales , Young Adult
11.
J Bone Joint Surg Br ; 94(11): 1557-66, 2012 Nov.
Article in English | MEDLINE | ID: mdl-23109639

ABSTRACT

United Kingdom National Institute for Health and Clinical Excellence guidelines recommend the use of total hip replacement (THR) for displaced intracapsular fractures of the femoral neck in cognitively intact patients, who were independently mobile prior to the injury. This study aimed to analyse the risk factors associated with revision of the implant and mortality following THR, and to quantify risk. National Joint Registry data recording a THR performed for acute fracture of the femoral neck between 2003 and 2010 were analysed. Cox proportional hazards models were used to investigate the extent to which risk of revision was related to specific covariates. Multivariable logistic regression was used to analyse factors affecting peri-operative mortality (< 90 days). A total of 4323 procedures were studied. There were 80 patients who had undergone revision surgery at the time of censoring (five-year revision rate 3.25%, 95% confidence interval 2.44 to 4.07) and 137 patients (3.2%) patients died within 90 days. After adjusting for patient and surgeon characteristics, an increased risk of revision was associated with the use of cementless prostheses compared with cemented (hazard ratio (HR) 1.33, p = 0.021). Revision was independent of bearing surface and head size. The risk of mortality within 90 days was significantly increased with higher American Society of Anesthesiologists (ASA) grade (grade 3: odds ratio (OR) 4.04, p < 0.001; grade 4/5: OR 20.26, p < 0.001; both compared with grades 1/2) and older age (≥ 75 years: OR 1.65, p = 0.025), but reduced over the study period (9% relative risk reduction per year). THR is a good option in patients aged < 75 years and with ASA 1/2. Cementation of the femoral component does not adversely affect peri-operative mortality but improves survival of the implant in the mid-term when compared with cementless femoral components. There are no benefits of using head sizes > 28 mm or bearings other than metal-on-polyethylene. More research is required to determine the benefits of THR over hemiarthroplasty in older patients and those with ASA grades > 2.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Femoral Neck Fractures/surgery , Prosthesis Failure , Reoperation/statistics & numerical data , Adolescent , Adult , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/adverse effects , Cohort Studies , Female , Hip Prosthesis , Humans , Logistic Models , Male , Middle Aged , Proportional Hazards Models , Registries , Retrospective Studies , Risk Factors , Survival Analysis , United Kingdom , Young Adult
12.
J Bone Joint Surg Br ; 94(7): 914-8, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22733945

ABSTRACT

We compared thromboembolic events, major haemorrhage and death after knee replacement in patients receiving either aspirin or low-molecular-weight heparin (LMWH). Data from the National Joint Registry for England and Wales were linked to an administrative database of hospital admissions in the English National Health Service. A total of 156,798 patients between April 2003 and September 2008 were included and followed for 90 days. Multivariable risk modelling was used to estimate odds ratios adjusted for baseline risk factors (AOR). An AOR < 1 indicates that risk rates are lower with LMWH than with aspirin. In all, 36,159 patients (23.1%) were prescribed aspirin and 120,639 patients (76.9%) were prescribed LMWH. We found no statistically significant differences between the aspirin and LMWH groups in the rate of pulmonary embolism (0.49% vs 0.45%, AOR 0.88 (95% confidence interval (CI) 0.74 to 1.05); p = 0.16), 90-day mortality (0.39% vs 0.45%, AOR 1.13 (95% CI 0.94 to 1.37); p = 0.19) or major haemorrhage (0.37% vs 0.39%, AOR 1.01 (95% CI 0.83 to 1.22); p = 0.94). There was a significantly greater likelihood of needing to return to theatre in the aspirin group (0.26% vs 0.19%, AOR 0.73 (95% CI 0.58 to 0.94); p = 0.01). Between patients receiving LMWH or aspirin there was only a small difference in the risk of pulmonary embolism, 90-day mortality and major haemorrhage. These results should be considered when the existing guidelines for thromboprophylaxis after knee replacement are reviewed.


Subject(s)
Anticoagulants/therapeutic use , Arthroplasty, Replacement, Knee/adverse effects , Aspirin/therapeutic use , Heparin, Low-Molecular-Weight/therapeutic use , Venous Thromboembolism/prevention & control , Aged , Anticoagulants/adverse effects , Arthroplasty, Replacement, Knee/methods , Aspirin/adverse effects , Drug Evaluation/methods , Drug Utilization/statistics & numerical data , England/epidemiology , Female , Heparin, Low-Molecular-Weight/adverse effects , Humans , Male , Middle Aged , Postoperative Care/methods , Postoperative Hemorrhage/chemically induced , Postoperative Hemorrhage/epidemiology , Pulmonary Embolism/epidemiology , Pulmonary Embolism/etiology , Pulmonary Embolism/prevention & control , Registries , Treatment Outcome , Venous Thromboembolism/epidemiology , Venous Thromboembolism/etiology , Wales/epidemiology
13.
J Bone Joint Surg Br ; 94(7): 919-27, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22733946

ABSTRACT

Following arthroplasty of the knee, the patient's perception of improvement in symptoms is fundamental to the assessment of outcome. Better clinical outcome may offset the inferior survival observed for some types of implant. By examining linked National Joint Registry (NJR) and patient-reported outcome measures (PROMs) data, we aimed to compare PROMs collected at a minimum of six months post-operatively for total (TKR: n = 23,393) and unicondylar knee replacements (UKR: n = 505). Improvements in knee-specific (Oxford knee score, OKS) and generic (EuroQol, EQ-5D) scores were compared and adjusted for case-mix differences using multiple regression. Whereas the improvements in the OKS and EQ-5D were significantly greater for TKR than for UKR, once adjustments were made for case-mix differences and pre-operative score, the improvements in the two scores were not significantly different. The adjusted mean differences in the improvement of OKS and EQ-5D were 0.0 (95% confidence interval (CI) -0.9 to 0.9; p = 0.96) and 0.009 (95% CI -0.034 to 0.015; p = 0.37), respectively. We found no difference in the improvement of either knee-specific or general health outcomes between TKR and UKR in a large cohort of registry patients. With concerns about significantly higher revision rates for UKR observed in worldwide registries, we question the widespread use of an arthroplasty that does not confer a significant benefit in clinical outcome.


Subject(s)
Arthroplasty, Replacement, Knee/methods , Patient Satisfaction , Aged , Arthroplasty, Replacement, Knee/adverse effects , Body Mass Index , Female , Humans , Male , Middle Aged , Postoperative Complications , Psychometrics , Quality of Life , Registries , Severity of Illness Index , Treatment Outcome
14.
J Bone Joint Surg Br ; 94(6): 746-54, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22628587

ABSTRACT

Modern metal-on-metal hip resurfacing has been widely performed in the United Kingdom for over a decade. However, the literature reports conflicting views of the benefits: excellent medium- to long-term results with some brands in specific subgroups, but high failure rates and local soft-tissue reactions in others. The National Joint Registry for England and Wales (NJR) has collected data on all hip resurfacings performed since 2003. This retrospective cohort study recorded survival time to revision from a resurfacing procedure, exploring risk factors independently associated with failure. All patients with a primary diagnosis of osteoarthritis who underwent resurfacing between 2003 and 2010 were included in the analyses. Cox's proportional hazard models were used to analyse the extent to which the risk of revision was related to patient, surgeon and implant covariates. A total of 27 971 hip resurfacings were performed during the study period, of which 1003 (3.59%) underwent revision surgery. In the final adjusted model, we found that women were at greater risk of revision than men (hazard ratio (HR) = 1.30, p = 0.007), but the risk of revision was independent of age. Of the implant-specific predictors, five brands had a significantly greater risk of revision than the Birmingham Hip Resurfacing (BHR) (ASR: HR = 2.82, p < 0.001, Conserve: HR = 2.03, p < 0.001, Cormet: HR = 1.43, p = 0.001, Durom: HR = 1.67, p < 0.001, Recap: HR = 1.58, p = 0.007). Smaller femoral head components were also significantly more likely to require revision (≤ 44 mm: HR = 2.14, p < 0.001, 45 to 47 mm: HR = 1.48, p = 0.001) than medium or large heads, as were operations performed by low-volume surgeons (HR = 1.36, p < 0.001). Once these influences had been removed, in 4873 male patients < 60 years old undergoing resurfacing with a BHR, the five-year estimated risk of revision was 1.59%. In summary, after adjustment for a range of covariates we found that there were significant differences in the rate of failure between brands and component sizes. Younger male patients had good five-year implant survival when the BHR was used.


Subject(s)
Arthroplasty, Replacement, Hip/adverse effects , Hip Prosthesis/adverse effects , Adult , Aged , Arthroplasty, Replacement, Hip/instrumentation , Arthroplasty, Replacement, Hip/methods , England/epidemiology , Female , Humans , Male , Metals , Middle Aged , Osteoarthritis, Hip/epidemiology , Osteoarthritis, Hip/surgery , Postoperative Period , Prosthesis Design , Prosthesis Failure/etiology , Registries , Reoperation/statistics & numerical data , Retrospective Studies , Risk Factors , Sex Factors , Wales/epidemiology
15.
QJM ; 105(5): 455-60, 2012 May.
Article in English | MEDLINE | ID: mdl-22294648

ABSTRACT

BACKGROUND: There is emerging evidence that patients with fractured neck of femur (FNOF) aged >85 years have different demands on a health-care system when compared to younger patients. AIM: We sought to better quantify this in terms of comorbidity and complication rates. DESIGN: Retrospective review of national database. METHODS: Data on all patients who underwent hip hemiarthroplasty for FNOF between January 2005 and December 2008 were extracted from the English hospital episode statistics database. RESULTS: There were 41 770 patients aged 65-84 years and 35 321 patients aged ≥85 years. The older cohort was less likely to have diabetes, chronic obstructive pulmonary disease and rheumatoid arthritis. However, they exhibited a significantly higher risk of lower respiratory tract infection [odds ratio (OR) = 1.58, 95% confidence interval (CI) 1.50-1.67)], myocardial infarction (OR = 1.67, 1.52-1.83) and acute renal failure (OR = 1.54, 1.40-1.70) within 30 days of surgery with an inpatient mortality risk at 90 days, double that of the younger age group. Length of stay (LoS) was significantly longer in patients >85 years compared to younger patients (median 18 days vs. 15, P < 0.001). CONCLUSION: Patients aged ≥85 years admitted for FNOF were found to have a lower incidence of major chronic disease but exhibited a greater incidence of acute events following hemiarthroplasty and their LoS was increased. Targeted medical interventions that focus upon this susceptible patient group may help reduce morbidity and improve survival.


Subject(s)
Arthroplasty, Replacement, Hip/methods , Femoral Neck Fractures/surgery , Postoperative Complications/epidemiology , Acute Kidney Injury/epidemiology , Aged , Aged, 80 and over , Female , Hospital Mortality , Humans , Length of Stay/statistics & numerical data , Male , Myocardial Infarction/epidemiology , Respiratory Tract Infections/epidemiology , Retrospective Studies , United Kingdom/epidemiology
16.
J Bone Joint Surg Br ; 93(11): 1465-70, 2011 Nov.
Article in English | MEDLINE | ID: mdl-22058295

ABSTRACT

We compared thromboembolic events, major haemorrhage and death after total hip replacement in patients receiving either aspirin or low-molecular-weight heparin (LMWH). We analysed data from the National Joint Registry for England and Wales linked to an administrative database of hospital admissions in the English National Health Service. A total of 108,584 patients operated on between April 2003 and September 2008 were included and followed up for 90 days. Multivariable risk modelling and propensity score matching were used to estimate odds ratios (OR) adjusted for baseline risk factors. An OR < 1 indicates that rates are lower with LMWH than with aspirin. In all, 21.1% of patients were prescribed aspirin and 78.9% LMWH. Without adjustment, we found no statistically significant differences. The rate of pulmonary embolism was 0.68% in both groups and 90-day mortality was 0.65% with aspirin and 0.61% with LMWH (OR 0.93; 95% CI 0.77 to 1.11). With risk adjustment, the difference in mortality increased (OR 0.84; 95% CI 0.69 to 1.01). With propensity score matching the mortality difference increased even further to 0.65% with aspirin and 0.51% with LMWH (OR 0.77; 95% CI 0.61 to 0.98). These results should be considered when the conflicting recommendations of existing guidelines for thromboprophylaxis after hip replacement are being addressed.


Subject(s)
Anticoagulants/therapeutic use , Arthroplasty, Replacement, Hip/adverse effects , Aspirin/therapeutic use , Heparin, Low-Molecular-Weight/therapeutic use , Venous Thromboembolism/prevention & control , Aged , Anticoagulants/adverse effects , Aspirin/adverse effects , Drug Evaluation/methods , England/epidemiology , Female , Heparin, Low-Molecular-Weight/adverse effects , Humans , Male , Middle Aged , Postoperative Care/methods , Postoperative Hemorrhage/chemically induced , Postoperative Hemorrhage/epidemiology , Pulmonary Embolism/epidemiology , Pulmonary Embolism/etiology , Pulmonary Embolism/prevention & control , Treatment Outcome , Venous Thromboembolism/epidemiology , Venous Thromboembolism/etiology , Wales/epidemiology
17.
J Bone Joint Surg Br ; 93(10): 1327-33, 2011 Oct.
Article in English | MEDLINE | ID: mdl-21969430

ABSTRACT

Arthroscopy of the knee is one of the most commonly performed orthopaedic procedures worldwide. Large-volume outcome data have not previously been available for English NHS patients. Prospectively collected admissions data, routinely collected on every English NHS patient, were analysed to determine the rates of complications within 30 days (including re-operation and re-admission), 90-day symptomatic venous thromboembolism and all-cause mortality. There were 301,701 operations performed between 2005 and 2010--an annual incidence of 9.9 per 10,000 English population. Of these, 16,552 (6%) underwent ligament reconstruction and 106,793 (35%) underwent meniscal surgery. The 30-day re-admission rate was 0.64% (1662) and 30-day wound complication rate was 0.26% (677). The overall 30-day re-operation rate was 0.40% (1033) and the 90-day pulmonary embolism rate was 0.08% (230), of which six patients died. 90-day mortality was 0.02% (47). Age < 40 years, male gender and ligament reconstruction were significantly associated with an increased rate of 30-day re-admission and unplanned re-operation. In addition, a significant increase in 30-day admission rates were seen with Charlson comorbidity scores of 1 (p = 0.037) and ≥ 2 (p < 0.001) compared with scores of 0, and medium volume units compared with high volume units (p < 0.001). Complications following arthroscopy of the knee are rare. It is a safe procedure, which in the majority of cases is performed as day case surgery. These data can be used for quality benchmarking, in terms of consent, consultant re-validation and individual unit performance.


Subject(s)
Arthroscopy/adverse effects , Knee Joint/surgery , State Medicine/statistics & numerical data , Adult , Age Distribution , Aged , Ambulatory Surgical Procedures/adverse effects , Ambulatory Surgical Procedures/statistics & numerical data , Arthroscopy/standards , Arthroscopy/statistics & numerical data , Databases, Factual , England , Female , Humans , Ligaments, Articular/surgery , Male , Menisci, Tibial/surgery , Middle Aged , Mortality , Patient Readmission/statistics & numerical data , Reoperation/statistics & numerical data , Venous Thromboembolism
18.
J Bone Joint Surg Br ; 93(8): 1011-6, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21768621

ABSTRACT

There is widespread concern regarding the incidence of adverse soft-tissue reactions after metal-on-metal (MoM) hip replacement. Recent National Joint Registry data have shown clear differences in the rates of failure of different designs of hip resurfacing. Our aim was to update the failure rates related to metal debris for the Articular Surface Replacement (ASR). A total of 505 of these were implanted. Kaplan-Meier analysis showed a failure rate of 25% at six years for the ASR resurfacing and of 48.8% for the ASR total hip replacement (THR). Of 257 patients with a minimum follow-up of two years, 67 (26.1%) had a serum cobalt concentration which was greater than 7 µg/l. Co-ordinate measuring machine analysis of revised components showed that all patients suffering adverse tissue reactions in the resurfacing group had abnormal wear of the bearing surfaces. Six THR patients had relatively low rates of articular wear, but were found to have considerable damage at the trunion-taper interface. Our results suggest that wear at the modular junction is an important factor in the development of adverse tissue reactions after implantation of a large-diameter MoM THR.


Subject(s)
Hip Prosthesis/adverse effects , Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Hip/methods , Chromium/blood , Cobalt/blood , Epidemiologic Methods , Equipment Failure Analysis/methods , Female , Humans , Male , Prosthesis Design , Prosthesis Failure , Reoperation
19.
J Bone Joint Surg Br ; 93(7): 876-80, 2011 Jul.
Article in English | MEDLINE | ID: mdl-21705556

ABSTRACT

Increased femoral head size may reduce dislocation rates following total hip replacement. The National Joint Registry for England and Wales has highlighted a statistically significant increase in the use of femoral heads ≥ 36 mm in diameter from 5% in 2005 to 26% in 2009, together with an increase in the use of the posterior approach. The aim of this study was to determine whether rates of dislocation have fallen over the same period. National data for England for 247 546 procedures were analysed in order to determine trends in the rate of dislocation at three, six, 12 and 18 months after operation during this time. The 18-month revision rates were also examined. Between 2005 and 2009 there were significant decreases in cumulative dislocations at three months (1.12% to 0.86%), six months (1.25% to 0.96%) and 12 months (1.42% to 1.11%) (all p < 0.001), and at 18 months (1.56% to 1.31%) for the period 2005 to 2008 (p < 0.001). The 18-month revision rates did not significantly change during the study period (1.26% to 1.39%, odds ratio 1.10 (95% confidence interval 0.98 to 1.24), p = 0.118). There was no evidence of changes in the coding of dislocations during this time. These data have revealed a significant reduction in dislocations associated with the use of large femoral head sizes, with no change in the 18-month revision rate.


Subject(s)
Arthroplasty, Replacement, Hip/adverse effects , Femur Head/pathology , Hip Dislocation/etiology , Hip Prosthesis , Age Distribution , Aged , Aged, 80 and over , Arthroplasty, Replacement, Hip/methods , Arthroplasty, Replacement, Hip/trends , England/epidemiology , Female , Hip Dislocation/epidemiology , Hip Dislocation/pathology , Humans , Male , Middle Aged , Prosthesis Design/trends , Prosthesis Failure , Registries , Reoperation/statistics & numerical data , State Medicine
20.
J Bone Joint Surg Br ; 93(4): 490-7, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21464488

ABSTRACT

Diagnostic and operative codes are routinely collected for every patient admitted to hospital in the English NHS. Data on post-operative complications following foot and ankle surgery have not previously been available in large numbers. Data on symptomatic venous thromboembolism events and mortality within 90 days were extracted for patients undergoing fixation of an ankle fracture, first metatarsal osteotomy, hindfoot fusions and total ankle replacement over a period of 42 months. For ankle fracture surgery (45 949 patients), the rates of deep-vein thrombosis (DVT), pulmonary embolism and mortality were 0.12%, 0.17% and 0.37%, respectively. For first metatarsal osteotomy (33 626 patients), DVT, pulmonary embolism and mortality rates were 0.01%, 0.02% and 0.04%, and for hindfoot fusions (7033 patients) the rates were 0.03%, 0.11% and 0.11%, respectively. The rate of pulmonary embolism in 1633 total ankle replacement patients was 0.06%, and there were no recorded DVTs and no deaths. Statistical analysis could only identify risk factors for venous thromboembolic events of increasing age and multiple comorbidities following fracture surgery. Venous thromboembolism following foot and ankle surgery is extremely rare, but this subset of fracture patients is at a higher risk. However, there is no evidence that thromboprophylaxis reduces this risk, and these national data suggest that prophylaxis is not required in most of these patients.


Subject(s)
Ankle/surgery , Anticoagulants/therapeutic use , Foot/surgery , Orthopedic Procedures/adverse effects , Postoperative Complications/etiology , Venous Thromboembolism/etiology , Adolescent , Adult , Aged , England , Female , Heparin/therapeutic use , Humans , Male , Middle Aged , Postoperative Complications/mortality , Postoperative Complications/prevention & control , Risk Assessment , Risk Factors , State Medicine , Venous Thromboembolism/mortality , Venous Thromboembolism/prevention & control , Young Adult
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