Numerical Investigation on High-Performance Cu-Based Surface Plasmon Resonance Sensor for Biosensing Application.

This numerical research presents a simple hybrid structure comprised of TiO2-Cu-BaTiO3 for a modified Kretschmann configuration that exhibits high sensitivity and high resolution for biosensing applications through an angular interrogation method. Recently, copper (Cu) emerged as an exceptional choice as a plasmonic metal for developing surface plasmon sensors (SPR) with high resolution as it yields finer, thinner SPR curves than Ag and Au. As copper is prone to oxidation, especially in ambient conditions, the proposed structure involves the utilization of barium titanate (BaTiO3) film as a protection layer that not only preserves Cu film from oxidizing but enhances the performance of the sensor to a great extent. Numerical results also show that the utilization of a thin adhesive layer of titanium dioxide (TiO2) between the prism base and Cu film not only induces strong interaction between them but also enhances the performance of the sensor. Such a configuration, upon suitable optimization of the thickness of each layer, is found to enhance sensitivity as high as 552°/RIU with a figure of merit (FOM) of 136.97 RIU-1. This suggested biosensor design with enhanced sensitivity is expected to enable long-term detection with greater accuracy and sensitivity even when using Cu as a plasmonic metal.

Model of the light sword intraocular lens: in-vitro comparative studies.

This work presents the first models of light sword intraocular lenses (LS IOLs) with angularly modulated optical power. We performed an experimental, comparative study with multifocal and extended depth of focus intraocular lenses, which are available on the market. The measurements conducted in an original optical bench were utilised for an analysis of point spread functions, elongated foci, modulation transfer functions and the areas defined by them. The LS IOL models perform homogeneous imaging in the whole range of designed defocus. The proposed concept of extended depth of focus seems to be promising for the development of presbyopia-correcting intraocular lenses capable of regaining fully functional vision.

The Light Sword Lens - A novel method of presbyopia compensation: Pilot clinical study.

PURPOSE: Clinical assessment of a new optical element for presbyopia correction-the Light Sword Lens. METHODS: Healthy dominant eyes of 34 presbyopes were examined for visual performance in 3 trials: reference (with lens for distance correction); stenopeic (distance correction with a pinhole ϕ = 1.25 mm) and Light Sword Lens (distance correction with a Light Sword Lens). In each trial, visual acuity was assessed in 7 tasks for defocus from 0.2D to 3.0D while contrast sensitivity in 2 tasks for defocus 0.3D and 2.5D. The Early Treatment Diabetic Retinopathy Study protocol and Pelli-Robson method were applied. Within visual acuity and contrast sensitivity results degree of homogeneity through defocus was determined. Reference and stenopeic trials were compared to Light Sword Lens results. Friedman analysis of variance, Nemenyi post-hoc, Wilcoxon tests were used, p-value < 0.05 was considered significant. RESULTS: In Light Sword Lens trial visual acuity was stable in tested defocus range [20/25-20/32], Stenopeic trial exhibited a limited range of degradation [20/25-20/40]. Light Sword Lens and reference trials contrast sensitivity was high [1.9-2.0 logCS] for both defocus cases, but low in stenopeic condition [1.5-1.7 logCS]. Between-trials comparisons of visual acuity results showed significant differences only for Light Sword Lens versus reference trials and in contrast sensitivity only for Light Sword Lens versus stenopeic trials. CONCLUSIONS: Visual acuity achieved with Light Sword Lens correction in presbyopic eye is comparable to stenopeic but exhibits none significant loss in contrast sensitivity. Such correction method seems to be very promising for novel contact lenses and intraocular lenses design.

Assessment of imaging with extended depth-of-field by means of the light sword lens in terms of visual acuity scale.

We present outcomes of an imaging experiment using the refractive light sword lens (LSL) as a contact lens in an optical system that serves as a simplified model of the presbyopic eye. The results show that the LSL produces significant improvements in visual acuity of the simplified presbyopic eye model over a wide range of defocus. Therefore, this element can be an interesting alternative for the multifocal contact and intraocular lenses currently used in ophthalmology. The second part of the article discusses possible modifications of the LSL profile in order to render it more suitable for fabrication and ophthalmological applications.

Diffuserless holographic projection working on twin spatial light modulators.

An improved efficient projection of holographic images is presented. It uses two phase spatial light modulators (SLMs) with two iteratively optimized Fresnel holograms displayed simultaneously--each for one modulator. The phase distribution on the second modulator is taking into account the light distribution coming from the first one. A pixelated structure of the modulator and fluctuations of liquid-crystal molecules cause a zero-order peak that was separated in experiment. Use of two SLMs gives clear and containing almost no speckles images. Thanks to the compensation of phase distribution from the first modulator, we can abandon diffusers in the iterative process and that is why we can control both amplitude and phase distribution in the image plane independently.

Visual Strehl performance of IOL designs with extended depth of focus.

PURPOSE: The use of monofocal, bifocal, or multifocal intraocular lenses (IOLs) is a common option to restore the refractive power of the eye in aphakic patients after cataract surgery. In this article, we study the predicted performance of two new designs of IOL, both with extended depth of focus: the quartic axicon and the light sword optical element (LSOE). These elements provide continuous focal segments spanning the range of dioptric power required for presbyopia compensation. METHODS: The performance analysis is based on the visual Strehl ratio (SR) computed in the spatial frequency domain, a neuro-optical quality metric that takes into account the effects of both the optical transfer function and the neural contrast sensitivity function. Furthermore, the classical SR and compound modulation transfer function were calculated. Some conventional transmittances of commercially available IOLs are also analyzed. RESULTS: The LSOE design has a more homogeneous behavior than other available solutions, providing a more uniform image quality over a significant fraction of the required addition range. CONCLUSIONS: The angular average of the visual SR computed in the spatial frequency domain and compound modulation transfer function indicate that both designs of extended depth of focus elements provide better optical quality on the whole addition range, except at the end points, than the discrete focus designs. The LSOE performed better than the quartic axicon in terms of uniformity of image quality within the same range.

Double peacock eye optical element for extended focal depth imaging with ophthalmic applications.

The aged human eye is commonly affected by presbyopia, and therefore, it gradually loses its capability to form images of objects placed at different distances. Extended depth of focus (EDOF) imaging elements can overcome this inability, despite the introduction of a certain amount of aberration. This paper evaluates the EDOF imaging performance of the so-called peacock eye phase diffractive element, which focuses an incident plane wave into a segment of the optical axis and explores the element's potential use for ophthalmic presbyopia compensation optics. Two designs of the element are analyzed: the single peacock eye, which produces one focal segment along the axis, and the double peacock eye, which is a spatially multiplexed element that produces two focal segments with partial overlapping along the axis. The performances of the peacock eye elements are compared with those of multifocal lenses through numerical simulations as well as optical experiments in the image space. The results demonstrate that the peacock eye elements form sharper images along the focal segment than the multifocal lenses and, therefore, are more suitable for presbyopia compensation. The extreme points of the depth of field in the object space, which represent the remote and the near object points, have been experimentally obtained for both the single and the double peacock eye optical elements. The double peacock eye element has better imaging quality for relatively short and intermediate distances than the single peacock eye, whereas the latter seems better for far distance vision.

Fabrication of phase masks with variable diffraction efficiency using HEBS glass technology.

A new fabrication method of apodized diffractive optical elements is proposed. It relies on using high energy beam sensitive glass as a halftone mask for variable diffraction efficiency phase masks generation in a resist layer. The presented technology is especially effective in mass production. Although fabrication of an amplitude mask is required, it is then repeatedly used in a single shot projection photolithography, which is much simpler and less laborious than the direct variable-dose pattern writing. Three prototypes of apodized phase masks were manufactured and characterized. The main advantages as well as limitations of the proposed technology are discussed.

Closed-loop adaptive optics with a single element for wavefront sensing and correction.

We propose a closed-loop adaptive optical arrangement based on a single spatial light modulator that simultaneously works as a correction unit and as the key element of a wavefront sensor. This is possible by using a liquid crystal on silicon display whose active area is divided into two halves that are respectively programmed for sensing and correction. We analyze the performance of this architecture to implement an adaptive optical system. Results showing a closed-loop operation are reported, as well as a proof of concept for dealing with aberrations comparable to those typically found in human eyes.

Modeling of amplification and light generation in one-dimensional photonic crystal using a multiwavelength transfer matrix approach.

We present an analysis of amplification and lasing in one-dimensional isotropic nonlinear photonic crystal (1D PC), which is based on a generalized (multiwavelength) transfer matrix method. This approach was used for modeling a Raman signal amplification in 1D PC and in an homogenous structure, showing advantages of a stratified medium. Moreover, the threshold operation of a 1D PC Raman laser is studied, assuming both strong as well as depleted pump. The normalized threshold gain characteristics for various end reflections and photonic crystal laser length were calculated.

Efficient compensation of Zernike modes and eye aberration patterns using low-cost spatial light modulators.

Off-the-shelf spatial light modulators (SLMs) like those commonly included in video projection devices have been seldom used for the compensation of eye aberrations, mainly due to the relatively low dynamic range of the phase retardation that can be introduced at each pixel. They present, however, some interesting features, such as high spatial resolution, easy handling, wide availability, and low cost. We describe an efficient four-level phase encoding scheme that allows us to use conventional SLMs for compensating optical aberrations as those typically found in human eyes. Experimental results are obtained with artificial eyes aberrated by refractive phase plates introducing either single Zernike terms or complex eye aberration patterns. This proof-of-concept is a step toward the use of low-cost, general purpose SLMs for the compensation of eye aberrations.

Lens axicons in oblique illumination.

Lens axicons, i.e., lenses or lens systems designed to work like axicons, can be a simple and inexpensive way of generating the characteristic axicon focal line. In the design of most lens axicons, only on-axis properties have been considered. We present the design of a lens axicon with improved off-axis characteristics. It is constructed from a singlet lens but with a double-pass feature that allows for a line of uniform width and a stop positioned to minimize aberrations. We perform off-axis analysis and experiments for this system and for another lens axicon, one designed for its on-axis characteristics. We conclude that the off-axis performance of the double-pass axicon is better than both that of an ordinary cone axicon and that of the other lens axicon.

Measurement and compensation of optical aberrations using a single spatial light modulator.

We describe a compact adaptive optical system using a spatial light modulator (SLM) as a single element to both measure and compensate optical aberrations. We used a low-cost, off-the-shelf twisted nematic liquid-crystal display (TNLCD) optimally configured to achieve maximum phase modulation with near constant transmittance. The TNLCD acts both as the microlens array of a Hartmann-Shack wavefront sensor and as the aberration compensation element. This adaptive setup is easy to implement and offers great versatility.

Presbyopia compensation with a quartic axicon.

PURPOSE: The purpose of this study was to evaluate the performance of quartic axicons for presbyopia compensation. The working principle relies on profiting the high depth of focus of the axicons to supplement the reduced accommodation amplitude of presbyopes. METHODS: We present the design equations of a particular kind of axicon to compensate a general presbyopia condition using simultaneous vision. A rotationally symmetric polynomial of fourth-order, corresponding to the well-known Seidel spherical aberration term, was chosen as its refractive profile. To validate its performance, we computed the retinal images with Stiles-Crawford apodization for a presbyopic eye compensated with this quartic axicon and compared them with those obtained without compensation or with other available solutions based on the simultaneous vision principle. RESULTS: The quartic axicon provides an important improvement of the image quality for intermediate distance vision in comparison with conventional bifocal and trifocal solutions. The image quality, however, is still not optimum for all distances. CONCLUSIONS: The results show the usefulness of the proposed approach and point out the need for developing further adapted optimizations.

Equilateral hyperbolic moiré zone plates with variable focus obtained by rotations.

We present equilateral hyperbolic zone plates with variable focal length, which are formed as moiré patterns by a mutual rotation of two identical basic grids. Among others, all principal zone plates, except of the spherical one, can be used as these basic transmittances. Three most important advantages of the proposed moiré zone plates are: a constant aperture of the created element during the mutual movement of basic grids, lack of aberrations due to their undesired mutual lateral displacements and high diffraction efficiency of the binary phase version. To obtain clearer moiré fringe pattern, a radial carrier frequency can be added additionally to the transmittances of basic grids. The destructive interference between both arms of the focal cross of the equilateral hyperbolic moiré zone plate can be obtained by a constant phase shift introduced in the transmittances of the basic grids. Potential applications of discussed elements are indicated, including the most promising one in the three-point alignment technique.

Simple lens axicon.

We present the design of a cemented doublet-lens axicon made from spherical surfaces only. Compared with diffractive axicons, refractive cone axicons, and earlier lens axicons with aspheric surfaces, this element is inexpensive and easy to manufacture even with large apertures. The lens axicon is based on the deliberate use of the spherical aberration of the surfaces. The design principles of the element and its characterization, numerically and experimentally, are presented in detail. Although performance was traded for simplicity and robustness, the results show that the lens axicon has the main axicon properties: a narrow, extended line focus of relatively constant width.

Diffractive axicons in oblique illumination: analysis and experiments and comparison with elliptical axicons.

Axicons in oblique illumination produce broadened focal lines, a problem, e.g., in scanning applications. A compact mathematical description of the focal segment is presented, for the first time, to our knowledge, and the results are compared with elliptical axicons in normal illumination. In both cases, analytical expressions in the form of asteroid curves are obtained from asymptotic wave theory and caustic surfaces. The results are confirmed by direct diffraction simulations and by experiments. In addition we show that at a fixed angle an elliptical axicon can be used to compensate for the adverse effects of oblique illumination.

Design of diffractive axicons producing uniform line images in Gaussian Schell-model illumination.

We present a design method for diffractive axicons in spatially partially coherent Gaussian Schell-model illumination. The method of stationary phase applied to the Fresnel diffraction integral for on-axis intensity leads, on requiring a uniform axial image profile, to a second-order differential equation for the optimal axicon phase function. The first integral can be formally performed, and the phase function is subsequently obtained numerically. The correctness of the synthesized phase profiles is confirmed by numerical simulations using partially coherent Fresnel diffraction theory. The effects of input-beam spot size and coherence width are assessed, and influences of different forms of apodization, including asymmetric functions for narrow incident beams, in annular-aperture diffractive axicons are examined.