Antidotes in Clinical Toxicology-Critical Review.

Poisoning and overdose are very important aspects in medicine and toxicology. Chemical weapons pose a threat to civilians, and emergency medicine principles must be followed when dealing with patients who have been poisoned or overdosed. Antidotes have been used for centuries and modern research has led to the development of new antidotes that can accelerate the elimination of toxins from the body. Although some antidotes have become less relevant due to modern intensive care techniques, they can still save lives or reduce the severity of toxicity. The availability of antidotes is crucial, especially in developing countries where intensive care facilities may be limited. This article aims to provide information on specific antidotes, their recommended uses, and potential risks and new uses. In the case of poisoning, supportive therapies are most often used; however, in many cases, the administration of an appropriate antidote saves the patient's life. In this review, we reviewed the literature on selected antidotes used in the treatment of poisonings. We also characterised the antidotes (bio)chemically. We described the cases in which they are used together with the dosage recommendations. We also analysed the mechanisms of action. In addition, we described alternative methods of using a given substance as a drug, an example of which is N-acetylcysteine, which can be used in the treatment of COVID-19. This article was written as part of the implementation of the project of the Polish Ministry of Education and Science, "Toxicovigilance, poisoning prevention, and first aid in poisoning with xenobiotics of current clinical importance in Poland", grant number SKN/SP/570184/2023.

Questioning Gender and Sexual Identity in the Context of Self-Concept Clarity, Sense of Coherence and Value System.

Sexual and gender identity is a fundamental part of one's overall identity and plays an important role in human functioning. Questioning one's sexuality associated with low level of self-concept clarity, certainty, consistency and stability with regard to the individual's beliefs about oneself, can affect their sense of coherence and value system. The aim of the study was to compare heterosexual and cisgender people with non-heteronormative and non-cisgender people regarding their attitudes and the way they perceive significant personal values. It was assumed that non-heterosexual and non-cisgender individuals would have lower self-concept clarity and lower sense of coherence, and that among them such values as openness to change and transcending Self would be dominant. The study was conducted on a group of 337 individuals aged 18 to 30. The participants filled out four self-report online questionnaires. Self-concept clarity was found to be connected with a greater tendency to question one's sexual and gender identity. The results also indicate differences between heterosexual/cisgender participants and non-heterosexual/non-cisgender participants in terms of the degree of self-concept clarity and sense of coherence. Non-heteronormative and cisgender individuals show a greater tendency to question their identity and have lower self-concept clarity, which may lower their sense of coherence.