Eccentric Exercise-Induced Muscle Damage Reduces Gross Efficiency.

INTRODUCTION: The effect of eccentric exercise-induced muscle damage (EIMD) on cycling efficiency is unknown. The aim of the present study was to assess the effect of EIMD on gross and delta efficiency and the cardiopulmonary responses to cycle ergometry. METHODS: Twenty-one recreational athletes performed cycling at 70%, 90%, and 110% of the gas exchange threshold (GET) under control conditions (Control) and 24 h following an eccentric damaging protocol (Damage). Knee extensor isometric maximal voluntary contraction, potentiated twitch ( Qtw,pot ), and voluntary activation were assessed before Control and Damage. Gross and delta efficiency were assessed using indirect calorimetry, and cardiopulmonary responses were measured at each power output. Electromyography root-mean-square (EMG RMS ) during cycling was also determined. RESULTS: Maximal voluntary contraction was 25% ± 18% lower for Damage than Control ( P < 0.001). Gross efficiency was lower for Damage than Control ( P < 0.001) by 0.55% ± 0.79%, 0.59% ± 0.73%, and 0.60% ± 0.87% for 70%, 90%, and 110% GET, respectively. Delta efficiency was unchanged between conditions ( P = 0.513). Concurrently, cycling EMG RMS was higher for Damage than Control ( P = 0.004). An intensity-dependent increase in breath frequency and V̇ E /V̇CO 2 was found, which were higher for Damage only at 110% GET ( P ≤ 0.019). CONCLUSIONS: Thus, gross efficiency is reduced following EIMD. The concurrently higher EMG RMS suggests that increases in muscle activation in the presence of EIMD might have contributed to reduced gross efficiency. The lack of change in delta efficiency might relate to its poor reliability hindering the ability to detect change. The findings also show that EIMD-associated hyperventilation is dependent on exercise intensity, which might relate to increases in central command with EIMD.

Caffeine ingestion compromises thermoregulation and does not improve cycling time to exhaustion in the heat amongst males.

PURPOSE: Caffeine is a commonly used ergogenic aid for endurance events; however, its efficacy and safety have been questioned in hot environmental conditions. The aim of this study was to investigate the effects of acute caffeine supplementation on cycling time to exhaustion and thermoregulation in the heat. METHODS: In a double-blind, randomised, cross-over trial, 12 healthy caffeine-habituated and unacclimatised males cycled to exhaustion in the heat (35 °C, 40% RH) at an intensity associated with the thermoneutral gas exchange threshold, on two separate occasions, 60 min after ingesting caffeine (5 mg/kg) or placebo (5 mg/kg). RESULTS: There was no effect of caffeine supplementation on cycling time to exhaustion (TTE) (caffeine; 28.5 ± 8.3 min vs. placebo; 29.9 ± 8.8 min, P = 0.251). Caffeine increased pulmonary oxygen uptake by 7.4% (P = 0.003), heat production by 7.9% (P = 0.004), whole-body sweat rate (WBSR) by 21% (P = 0.008), evaporative heat transfer by 16.5% (P = 0.006) and decreased estimated skin blood flow by 14.1% (P < 0.001) compared to placebo. Core temperature was higher by 0.6% (P = 0.013) but thermal comfort decreased by - 18.3% (P = 0.040), in the caffeine condition, with no changes in rate of perceived exertion (P > 0.05). CONCLUSION: The greater heat production and storage, as indicated by a sustained increase in core temperature, corroborate previous research showing a thermogenic effect of caffeine ingestion. When exercising at the pre-determined gas exchange threshold in the heat, 5 mg/kg of caffeine did not provide a performance benefit and increased the thermal strain of participants.

Topical application of isolated menthol and combined menthol-capsaicin creams: Exercise tolerance, thermal perception, pain, attentional focus and thermoregulation in the heat.

We determined the effects of topically applied (i) isolated menthol cream, (ii) menthol and capsaicin co-application or (iii) placebo cream on exercise tolerance, thermal perception, pain, attentional focus and thermoregulation during exercise in the heat. Ten participants cycled at 70% maximal power output until exhaustion in 35°C and 20% relative humidity after application of (i) 5% isolated menthol, (ii) 5% menthol and 0.025% capsaicin co-application or (iii) placebo cream. Thermo-physiological responses were measured during exercise, with attentional focus and pain determined post-exercise on a 0-to-10 scale. Across the three conditions, time to exhaustion was 13.4 ± 4.8 min, mean ± SD infrared tympanic and skin temperature was 37.2 ± 0.6°C and 35.1 ± 1.2°C, respectively, and heart rate was 152 ± 47 bpm, with no changes between conditions (p > 0.05). Perceived exertion was lower in the isolated menthol vs. all other conditions (p < 0.05, ηp2 = 0.44). Thermal sensation was higher in menthol-capsaicin co-application vs. isolated menthol (p < 0.05, d = 1.1), while sweat rate was higher for capsaicin and menthol co-application compared to menthol (p < 0.05, d = 0.85). The median and interquartile range scores for pain were lower (p < 0.05) in the menthol condition (8, 7-8) compared to both menthol and capsaicin (10, 9-10) and placebo (9, 9-10), which was coupled with a greater distraction (p < 0.05) in the menthol condition (9, 7-10) compared to placebo (6, 5-7). Despite no performance effects for any topical cream application condition, these data reiterate the advantageous perceptual and analgesic role of menthol application and demonstrate no advantage of co-application with capsaicin.HighlightsTopical application of isolated menthol cream to cold-sensitive areas of the body during exhaustive exercise in the heat, elicited reduced perception of pain and enhanced sensation of cooling.While this reduction in generally unpleasant feelings (i.e. pain and heat) were coupled with lower RPE scores in the menthol condition and could be considered beneficial, there was no apparent ergogenic effect in an exercise tolerance test.Co-application of capsaicin and menthol appeared to inhibit the positive sensory effects elicited by menthol.Isolated menthol can induce changes in cognitive processes related to pain and exertion, while also reducing thermal sensation; however, the decision to use menthol creams must be balanced with the limited performance or thermoregulatory effects reported herein during exercise in hot environments.

Factors contributing to the change in thermoneutral maximal oxygen consumption after iso-intensity heat acclimation programmes.

The factors explaining variance in thermoneutral maximal oxygen uptake (V˙O2max) adaptation to heat acclimation (HA) were evaluated, with consideration of HA programme parameters, biophysical variables and thermo-physiological responses. Seventy-one participants consented to perform iso-intensity training (range: 45%-55% V˙O2max) in the heat (range: 30°C-38°C; 20%-60% relative humidity) on consecutive days (range: 5-days-14-days) for between 50-min and-90 min. The participants were evaluated for their thermoneutral V˙O2max change pre-to-post HA. Participants' whole-body sweat rate, heart rate, core temperature, perceived exertion and thermal sensation and plasma volume were measured, and changes in these responses across the programme determined. Partial least squares regression was used to explain variance in the change in V˙O2max across the programme using 24 variables. Sixty-three percent of the participants increased V˙O2max more than the test error, with a mean ± SD improvement of 2.6 ± 7.9%. A two-component model minimised the root mean squared error and explained the greatest variance (R2; 65%) in V˙O2max change. Eight variables positively contributed (P < 0.05) to the model: exercise intensity (%V˙O2max), ambient temperature, HA training days, total exposure time, baseline body mass, thermal sensation, whole-body mass losses and the number of days between the final day of HA and the post-testing day. Within the ranges evaluated, iso-intensity HA improved V˙O2max 63% of the time, with intensity - and volume-based parameters, alongside sufficient delays in post-testing being important considerations for V˙O2max maximisation. Monitoring of thermal sensation and body mass losses during the programme offers an accessible way to gauge the degree of potential adaptation.

Comparison of the effects of velocity-based vs. traditional resistance training methods on adaptations in strength, power, and sprint speed: A systematic review, meta-analysis, and quality of evidence appraisal.

We estimated the effectiveness of using velocity feedback to regulate resistance training load on changes in muscle strength, power, and linear sprint speed in apparently healthy participants. Academic and grey literature databases were systematically searched to identify randomised trials that compared a velocity-based training intervention to a 'traditional' resistance training intervention that did not use velocity feedback. Standardised mean differences (SMDs) were pooled using a random effects model. Risk of bias was assessed with the Risk of Bias 2 tool and the quality of evidence was evaluated using the GRADE approach. Four trials met the eligibility criteria, comprising 27 effect estimates and 88 participants. The main analyses showed trivial differences and imprecise interval estimates for effects on muscle strength (SMD 0.06, 95% CI -0.51-0.63; I2 = 42.9%; 10 effects from 4 studies; low-quality evidence), power (SMD 0.11, 95% CI -0.28-0.49; I2 = 13.5%; 10 effects from 3 studies; low-quality evidence), and sprint speed (SMD -0.10, 95% CI -0.72-0.53; I2 = 30.0%; 7 effects from 2 studies; very low-quality evidence). The results were robust to various sensitivity analyses. In conclusion, there is currently no evidence that VBT and traditional resistance training methods lead to different alterations in muscle strength, power, or linear sprint speed.

Repeated Ischemic Preconditioning Effects on Physiological Responses to Hypoxic Exercise.

INTRODUCTION: Repeated ischemic preconditioning (IPC) can improve muscle and pulmonary oxygen on-kinetics, blood flow, and exercise efficiency, but these effects have not been investigated in severe hypoxia. The aim of the current study was to evaluate the effects of 7 d of IPC on resting and exercising muscle and cardio-pulmonary responses to severe hypoxia.METHODS: A total of 14 subjects received either: 1) 7 d of repeated lower-limb occlusion (4 × 5 min, 217 ± 30 mmHg) at limb occlusive pressure (IPC) or SHAM (4 × 5 min, 20 mmHg). Subjects were tested for resting limb blood flow, relative microvascular deoxyhemoglobin concentration ([HHB]), and pulmonary oxygen (Vo2p) responses to steady state and incremental exercise to exhaustion in hypoxia (fractional inspired O2 = 0.103), which was followed by 7 d of IPC or SHAM and retesting 72 h post-intervention.RESULTS: There were no effects of IPC on maximal oxygen consumption, time to exhaustion during the incremental test, or minute ventilation and arterial oxygen saturation. However, the IPC group had higher delta efficiency based on pooled results and lower steady state Δ[HHB] (IPC ∼24% vs. SHAM ∼6% pre to post), as well as slowing the [HHB] time constant (IPC ∼26% vs. SHAM ∼3% pre to post) and reducing the overshoot in [HHB]: Vo2 ratio during exercise onset.CONCLUSIONS: Collectively, these results demonstrate that muscle O2 efficiency and microvascular O2 distribution can be improved by repeated IPC, but there are no effects on maximal exercise capacity in severe hypoxia.Chopra K, Jeffries O, Tallent J, Heffernan S, Kilduff L, Gray A, Waldron M. Repeated ischemic preconditioning effects on physiological responses to hypoxic exercise. Aerosp Med Hum Perform. 2022; 93(1):13-21.

Custom-Fitted Compression Garments Enhance Recovery From Muscle Damage in Rugby Players.

ABSTRACT: Brown, F, Jeffries, O, Gissane, C, Howatson, G, van Someren, K, Pedlar, C, Myers, T, and Hill, JA. Custom-fitted compression garments enhance recovery from muscle damage in rugby players. J Strength Cond Res 36(1): 212-219, 2022-to evaluate the effects of custom-fitted compression garments (CG) on recovery from muscle damage in rugby players. Forty-five players were tested for lower-body strength, power, and indices of muscle damage before completing a damaging protocol (20 × 20-m sprints with 5-m deceleration, 100 drop jumps). Players were randomly assigned to wear either custom-fitted (CF, n = 13), or standard-sized CG (SSG, n = 16), or to receive sham ultrasound therapy (CON, n = 16) immediately after exercise. Players were retested immediately, then after 24 and 48 hours. Strength recovery was significantly different between groups (F = 2.7, p = 0.02), with only CF recovering to baseline values by 48 hours (p = 0.973). Time × condition effects were also apparent for creatine kinase activity (χ2 = 30.4, p < 0.001) and midthigh girth (F = 3.7, p = 0.005), with faster recovery apparent in CF compared with both CON and SSG (p < 0.05). Custom-fitted CG improved strength recovery and indices of muscle damage in rugby players, compared with controls and standard-sized garments. Athletes and coaches would be advised to use appropriately fitted CG to enhance strength recovery after damaging exercise.

Physiological and thermoregulatory effects of oral taurine supplementation on exercise tolerance during forced convective cooling.

AbstractWe investigated the effects of taurine supplementation on cycling time to exhaustion in cold conditions. Eleven males cycled to exhaustion at a power output equivalent to the mid-point between ventilatory threshold and maximum aerobic power following 15-min rest in the cold (apparent temperature of ∼ 4°C; air flow of 4.17 m s-1). Two hours before, participants ingested taurine (50 mg·kg-1) or placebo beverage. Pulmonary gases, carbohydrate (CHO) and fat oxidation, body temperatures, mean local sweat rate, heart rate, rate of perceived exertion (RPE) and thermal comfort were recorded. Time to exhaustion was not different between trials (taurine = 14.6 ± 4.7 min; placebo = 13.4 ± 5.6 min, P = 0.061, d = 0.27). There were no effects (P > 0.05) of taurine on core temperature, mean skin temperature or local sweat rates. However, the placebo condition showed greater (P < 0.05) reductions in arm-to-finger temperature gradient (i.e. vasodilation) across pre-exercise passive cold exposure and increased CHO oxidation (P < 0.05). Participants also reached a thermally 'comfortable' level quicker in the taurine condition (P < 0.05). A 50 mg·kg-1 dose of taurine did not statistically benefit endurance exercise after moderate cold exposure but conferred some potential vascular and metabolic effects.

Effects of Heat Acclimation and Acclimatisation on Maximal Aerobic Capacity Compared to Exercise Alone in Both Thermoneutral and Hot Environments: A Meta-Analysis and Meta-Regression.

BACKGROUND: Heat acclimation and acclimatisation (HA) is typically used to enhance tolerance to the heat, thereby improving performance. HA might also confer a positive adaptation to maximal oxygen consumption ([Formula: see text]), although this has been historically debated and requires clarification via meta-analysis. OBJECTIVES: (1) To meta-analyse all studies (with and without control groups) that have investigated the effect of HA on [Formula: see text] adaptation in thermoneutral or hot environments; (2) Conduct meta-regressions to establish the moderating effect of selected variables on [Formula: see text] adaptation following HA. METHODS: A search was performed using various databases in May 2020. The studies were screened using search criteria for eligibility. Twenty-eight peer-reviewed articles were identified for inclusion across four separate meta-analyses: (1) Thermoneutral [Formula: see text] within-participants (pre-to-post HA); (2) Hot [Formula: see text] within-participants (pre-to-post HA); (3) Thermoneutral [Formula: see text] measurement; HA vs. control groups; (4) Hot [Formula: see text] measurement, HA vs. control groups. Meta-regressions were performed for each meta-analysis based on: isothermal vs. iso-intensity programmes, days of heat exposure, HA ambient temperature (°C), heat index, HA session duration (min), ambient thermal load (HA session x ambient temperature), mean mechanical intensity (W) and the post-HA testing period (days). RESULTS: The meta-analysis of pre-post differences in thermoneutral [Formula: see text] demonstrated small-to-moderate improvements in [Formula: see text] (Hedges' g = 0.42, 95% CI 0.24-0.59, P < 0.001), whereas moderate improvements were found for the equivalent analysis of hot [Formula: see text] changes (Hedges' g = 0.63, 95% CI 0.26-1.00, P < 0.001), which were positively moderated by the number of days post-testing (P = 0.033, ß = 0.172). Meta-analysis of control vs. HA thermoneutral [Formula: see text] demonstrated a small improvement in [Formula: see text] in HA compared to control (Hedges' g = 0.30, 95% CI 0.06-0.54, P = 0.014) and this effect was larger for the equivalent hot [Formula: see text] analysis where a higher (moderate-to-large) improvement in [Formula: see text] was found (Hedges' g = 0.75, 95% CI 0.22-1.27, P = 0.005), with the number of HA days (P = 0.018; ß = 0.291) and the ambient temperature during HA (P = 0.003; ß = 0.650) positively moderating this effect. CONCLUSION: HA can enhance [Formula: see text] adaptation in thermoneutral or hot environments, with or without control group consideration, by at least a small and up to a moderate-large amount, with the larger improvements occurring in the heat. Ambient heat, number of induction days and post-testing days can explain some of the changes in hot [Formula: see text] adaptation.

The effect of acute and repeated ischemic preconditioning on recovery following exercise-induced muscle damage.

OBJECTIVES: The aim of this investigation was to determine if acute or repeated applications of ischemic preconditioning (IPC) could enhance the recovery process, following exercise induced muscle damage (EIMD). DESIGN: Randomized control trial. METHODS: Twenty-three healthy males were familiarised with the muscle damaging protocol (five sets of 20 drop jumps from a 0.6 m box) and randomly allocated to one of three groups: SHAM (3 × 5 min at 20 mmHg), Acute IPC (3 × 5 min at 220 mmHg) and Repeated IPC (3 days x 3 × 5 min at 220 mmHg). The indices of muscle damage measured included creatine kinase concentration ([CK]), thigh swelling, delayed onset muscle soreness, counter movement jumps (CMJ) and maximal voluntary isometric contraction (MVIC). RESULTS: Both acute and repeated IPC improved recovery in MVIC versus SHAM. Repeated IPC led to a faster MVIC recovery at 48 h (101.5%) relative to acute IPC (92.6%) and SHAM (84.4%) (P <  0.05). Less swelling was found for both acute and repeated IPC vs. SHAM (P <  0.05) but no group effects were found for CMJ, soreness or [CK] responses (P >  0.05). CONCLUSION: Taken together, repeated IPC can enhance recovery time of MVIC more than an acute application, and both reduce swelling following EIMD, relative to a SHAM condition.

No thermoregulatory or ergogenic effect of dietary nitrate among physically inactive males, exercising above gas exchange threshold in hot and dry conditions.

The aim of this study was to determine the effect of five days dietary nitrate (NO3-) consumption on exercise tolerance and thermoregulation during cycling in hot, dry conditions. In a double-blind, randomised crossover design, 11 healthy males participated in an exercise tolerance test (Tlim) in the heat (35°C, 28% relative humidity), cycling above the thermoneutral gas exchange threshold, after five days of dietary supplementation, with either NO3-rich beetroot juice (BR; ∼ 9.2 mmol NO3-) or placebo (PLA). Changes in plasma [NO3-] and nitrite [NO2-], core and mean skin temperatures, mean local and whole-body sweat rates, heart rate, perceptual ratings and pulmonary gas exchange were measured during exercise, alongside calorimetric estimations of thermal balance. Mean arterial pressures (MAP) were recorded pre-Tlim. There were no differences in Tlim between conditions (BR = 22.8 ± 8.1 min; Placebo = 20.7 ± 7.9 min) (P = 0.184), despite increases in plasma [NO3-] and [NO2-] (P < 0.001) and a 3.8% reduction in resting MAP (P = 0.004) in the BR condition. There were no other differences in thermoregulatory, cardio-metabolic, perceptual or calorimetric responses to the Tlim between conditions (P > 0.05). Dietary NO3- supplementation had no effect on exercise tolerance or thermoregulation in hot, dry conditions, despite reductions in resting MAP and increases in plasma [NO3-] and [NO2-]. Healthy, yet physically inactive individuals with no known impairments in vasodilatory and sudomotor function do not appear to require BR for ergogenic or thermolytic effects during exercise in the heat.

Functional Threshold Power Is Not Equivalent to Lactate Parameters in Trained Cyclists.

ABSTRACT: Jeffries, O, Simmons, R, Patterson, SD, and Waldron, M. Functional threshold power is not equivalent to lactate parameters in trained cyclists. J Strength Cond Res 35(10): 2790-2794, 2021-Functional threshold power (FTP) is derived from a maximal self-paced 20-minute cycling time trial whereby the average power output is scaled by 95%. However, the physiological basis of the FTP concept is unclear. Therefore, we evaluated the relationship of FTP with a range of laboratory-based blood lactate parameters derived from a submaximal threshold test. Twenty competitive male cyclists completed a maximal 20-minute time trial and an incremental exercise test to establish a range of blood lactate parameters. Functional threshold power (266 ± 42 W) was strongly correlated (r = 0.88, p < 0.001) with the power output associated with a fixed blood lactate concentration 4.0 mmol·L-1 (LT4.0) (268 ± 30 W) and not significantly different (p > 0.05). While mean bias was 2.9 ± 24.6 W, there were large limits of agreement (LOA) between FTP and LT4.0 (-45 to 51 W). All other lactate parameters, lactate threshold (LT) (236 ± 32 W), individual anaerobic threshold (244 ± 33 W), and LT thresholds determined using the Dmax method (221 ± 25 W) and modified Dmax method (238 ± 32 W) were significantly different from FTP (p < 0.05). While FTP strongly correlated with LT4.0, the large LOA refutes any equivalence as a measure with physiological basis. Therefore, we would encourage athletes and coaches to use alternative field-based methods to predict cycling performance.

Thermo-behavioural responses to orally applied l-menthol exhibit sex-specific differences during exercise in a hot environment.

AIMS: This study investigated the efficacy of l-menthol mouth-rinsing on thermal sensation and perceived effort in females and males, using a fixed-rating of perceived exertion (RPE) exercise protocol in a hot environment. METHODS: Twenty-two participants (eleven females, eleven males) completed two trials using a fixed-RPE protocol at an exercise intensity between 'hard' and 'very hard', equating to 16 on the RPE scale at ~35 °C. Participants adjusted power output to maintain RPE-16. In a randomised, double-blind, crossover design, l-menthol or a control mouthwash was administered at an orally neutral temperature (~32 °C) prior to exercise and at 10 min intervals thereafter. Measures of mechanical power output, core temperature, heart rate, perception of thermal sensation and thermal comfort, and whole-body sweat loss are reported. RESULTS: Thermal sensation was lowered by l-menthol in both sexes (P < 0.05), however during exercise this was only maintained for 40% of the trial duration in females. Thermal comfort did not differ between conditions (P > 0.05). No differences in exercise duration were observed compared to control, despite a ~4% and ~6% increase in male and females respectively. Power output increased by ~6.5% males (P = 0.039) with no difference in females ~2.2% (P = 0.475), compared to control. Core temperature, heart rate and whole-body sweat loss was not different between condition or sex. CONCLUSIONS: l-menthol lowered perceptual measures of thermal sensation in females, but did not attenuate a greater rate of rise in thermal sensitivity when exercising in a hot environment, compared to males. Males appeared to adopt a higher risk strategy by increasing power output following l-menthol administration in contrast to a more conservative pacing strategy in females. Therefore, there appear to be sex-specific differences in l-menthol's non-thermal cooling properties and subsequent effects on thermo-behavioural adjustments in work-load when exercising in a hot environment.

Physiological Responses to Linear and Nonlinear Soccer-specific Match Simulations and Their Effects on Lower-Limb Muscle Fatigue.

Uddin, N, Jeffries, O, Read, P, Howe, L, Patterson, S, and Waldron, M. Physiological responses to linear and nonlinear soccer-specific match simulations and their effects on lower-limb muscle fatigue. J Strength Cond Res 34(11): 3232-3240, 2020-The aims of this study were to: (a) investigate the effects of linear and nonlinear soccer simulations on lower-limb muscle function and physiological responses and (b) evaluate the relationship between match-running demands and changes in lower-limb muscle function. In a repeated-measures cross-over design, 8 participants completed either a linear or nonlinear adapted Loughborough Intermittent Shuttle Test (LIST) on 2 occasions. The movement of players was tracked with a global positioning system, while lower-limb muscle function tests and physiological measurements were performed before and every 15 minutes during the simulation. There were no differences in distance covered, yet high-speed running (p = 0.007), accelerations (p = 0.008), and decelerations (p = 0.015) were higher in the linear LIST. Mean heart rate (p = 0.001) and ratings of perceived exertion (p = 0.013) were higher in the nonlinear LIST. Peak landing forces (p = 0.017) and jump height (p = 0.001) were reduced between baseline and 90 minutes but were not different between conditions. Changes in peak landing forces from baseline to half-time (r = -0.57, n = 16, p = 0.022) and full-time (r = -0.58, n = 16, p = 0.019) were related to high-speed running. Hamstring force was unaffected by time (p = 0.448) but was reduced in the linear LIST (p = 0.044). Protocols posing different external and internal demands elicited similar levels of fatigue across simulations. Hamstring function was not an effective indicator of fatigue, but our results highlight the greater demands placed on this muscle group when higher-speed running is performed.

The effects of vitamin C and E on exercise-induced physiological adaptations: a systematic review and Meta-analysis of randomized controlled trials.

We conducted a systematic review and meta-analysis of randomized controlled trials examining the effect of vitamin C and/or E on exercise-induced training adaptations. Medline, Embase and SPORTDiscus databases were searched for articles from inception until June 2019. Inclusion criteria was studies in adult humans where vitamin C and/or E had to be consumed alongside a supervised exercise training program of ≥4 weeks. Nine trials were included in the analysis of aerobic exercise adaptations and nine for resistance training (RT) adaptations. Vitamin C and/or E did not attenuate aerobic exercise induced improvements in maximal aerobic capacity (V̇O2max) (SMD -0.14, 95% CI: -0.43 to 0.15, P = 0.35) or endurance performance (SMD -0.01, 95% CI: -0.38 to 0.36, P = 0.97). There were also no effects of these supplements on lean mass and muscle strength following RT (SMD -0.07, 95% CI: -0.36 to 0.23, P = 0.67) and (SMD -0.15, 95% CI: -0.16 to 0.46, P = 0.35), respectively. There was also no influence of age on any of these outcomes (P > 0.05). These findings suggest that vitamin C and/or E does not inhibit exercise-induced changes in physiological function. Studies with larger sample sizes and adequate power are still required.

Energy Drink Doses of Caffeine and Taurine Have a Null or Negative Effect on Sprint Performance.

Jeffries, O, Hill, J, Patterson, SD, and Waldron, M. Energy drink doses of caffeine and taurine have a null or negative effect on sprint performance. J Strength Cond Res 34(12): 3475-3481, 2020-This study investigated the effects of caffeine and taurine coingestion on repeat-sprint cycling performance and associated physiological and perceptual responses. In a double-blind, cross-over, repeated measures study, 11 male subjects (age 21 ± 2 years; stature 178 ± 7 cm; body mass 80 ± 13 kg) completed 10 × 6-second sprints on a cycle ergometer, each separated by 24 seconds, one hour after ingesting: caffeine (80 mg) and taurine (1 g), equivalent to the amount observed in popular commercial energy drinks, or placebo (maltodextrin ∼1 g) in a gelatine capsule. Performance was measured on a cycle ergometer, whereas blood lactate concentration (B[la]), rating of perceived exertion (RPE), and heart rate (HR) were measured at baseline (pre-exercise) and after sprints 5 and 10. Magnitude-based inferences revealed likely, trivial differences in peak power and unclear, trivial intersprint fatigue index after ingestion of the caffeine and taurine supplement. Intrasprint fatigue was greater in the caffeine and taurine condition at sprint 10 (likely, small) and possibly smaller in sprints 6-9. The caffeine and taurine supplement had a likely large effect on HR at baseline (effect size = 0.94) and increases in B[la] after sprints 5 (likely small) and 10 (possibly small). There was no effect of the supplement on RPE (unclear, trivial). Administration of caffeine and taurine at doses equivalent to commercial energy drinks did not improve repeat-sprint cycling performance and seemed to induce greater fatigue within selected sprints, particularly at the end of the trial. This undesirable performance effect occurs in parallel with increased HR and glycolytic metabolic bi-products.

Oral taurine improves critical power and severe-intensity exercise tolerance.

This study investigated the effects of acute oral taurine ingestion on: (1) the power-time relationship using the 3-min all-out test (3MAOT); (2) time to exhaustion (TTE) 5% > critical power (CP) and (3) the estimated time to complete (Tlim) a range of fixed target intensities. Twelve males completed a baseline 3MAOT test on a cycle ergometer. Following this, a double-blind, randomised cross-over design was followed, where participants were allocated to one of four conditions, separated by 72 h: TTE + taurine; TTE + placebo; 3MAOT + taurine; 3MAOT + placebo. Taurine was provided at 50 mg kg-1, whilst the placebo was 3 mg kg-1 maltodextrin. CP was higher (P < 0.05) in taurine (212 ± 36 W) than baseline (197 ± 40 W) and placebo (193 ± 35 W). Work end power was not affected by supplement (P > 0.05), yet TTE 5% > CP increased (P < 0.05) by 1.7 min after taurine (17.7 min) compared to placebo (16.0 min) and there were higher (P < 0.001) estimated Tlim across all work targets. Acute supplementation of 50 mg kg-1 of taurine improved CP and estimated performance at a range of severe work intensities. Oral taurine can be taken prior to exercise to enhance endurance performance.

Seven-day ischaemic preconditioning improves muscle efficiency during cycling.

Ischaemic preconditioning (IPC) has emerged as a potential non-invasive ergogenic aid to enhance exercise performance. Repeated application of IPC has demonstrated clinical efficacy, therefore our aims were to investigate its effect on endurance cycling performance and muscle efficiency. Twenty participants undertook 7-d repeated bilateral lower limb occlusion (4 x 5-min) of IPC (220 mmHg) or sham (20 mmHg). Prior to and 72-h following the intervention, participants performed submaximal cycling at 70, 80 and 90% of ventilatory threshold (VT) followed by an incremental exercise test. IPC had no effect on V˙ O2max (P = 0.110); however, time to exhaustion increased by ~ 9% and Wmax by ~ 5 % (IPC pre 307 ± 45 to post 323 ± 51 W) relative to sham (P = 0.002). There were no changes in gross efficiency (GE) (P > 0.05); however, delta efficiency (DE) increased by 3.1% following IPC (P = 0.011). Deoxyhaemoglobin (HHb) was reduced following IPC ~ 30% (P = 0.017) with no change in total haemoglobin (tHb). Repeated IPC over 7-d enhanced muscle efficiency and extended cycling performance. The physiological effects of repeated IPC on skeletal muscle efficiency explains the notable improvements in endurance performance.