ABSTRACT
Incontinence-associated dermatitis is one of the common complications in critically ill patients.This paper reviews the research progress of risk prediction models for incontinence-associated dermatitis in critically ill patients,introduces and compares the characteristics and application effects of different risk prediction models.The purpose is to provide ideas for constructing a localized risk prediction model and provide evidence for medical staff to identify risk factors of incontinence-associated dermatitis at an early stage and take preventive measures.
ABSTRACT
As a complex system, the topology of human's brain network has an important effect on further study of brain's structural and functional mechanism. Graph theory, a kind of sophisticated analytic strategies, is widely used for analyzing complex brain networks effectively and comparing difference of topological structure alteration in normal development and pathological condition. For the purpose of using this analysis methodology efficiently, it is necessary to develop graph-based visualization software. Thus, we developed VisConnectome, which displays analysis results of the brain network friendly and intuitively. It provides an original graphical user interface (GUI) including the tool window, tool bar and innovative double slider filter, brain region bar, runs in any Windows operating system and doesn't rely on any platform such as Matlab. When importing the user-defined script file that initializes the brain network, VisConnectome abstracts the brain network to the ball-and-stick model and render it. VisConnectome allows a series of visual operations, such as identifying nodes and connection, modifying properties of nodes and connection such as color and size with the color palette and size double slider, imaging the brain regions, filtering the brain network according to its size property in a specific domain as simplification and blending with the brain surface as a context of the brain network. Through experiment and analysis, we conclude that VisConnectome is an effective visualization software with high speed and quality, which helps researchers to visualize and compare the structural and functional brain networks flexibly.
Subject(s)
Humans , Brain , Physiology , Connectome , SoftwareABSTRACT
Objective To investigate if Chondrus yendoi decoction(CYD) and polysaccharide(CYP) have the effects of scavenging superoxide anion(O?—2),antioxidation,protecting mitochondria from damage.Methods Lipid peroxidation and swelling of mouse liver and brain mitochondria were induced by Fe2+-L-Cys system in vitro.Superoxide anion was generated by reduced nicotinamide adenine dinucleotide(NADH)-N-methylphenazonium methyl sulfate(PMS)-4-nitrobluetetrazolium chloride(NBT) system.Lipid peroxide malondialdehyde(MDA),mitochondrial swelling and superoxide anion formation were determined by spectrophotometry.Results CYD and CYP could inhibit MDA production,protect mitochondria from swelling,and scavenge O?-2 obviously in a dose-dependent manner.Conclusion CYD and CYP had the effects of scavenging O?-2,antioxidation,protecting mitochondria from injury.CYP was the major bioactive component.