Subject(s)
Dermoscopy , Sea Urchins , Humans , Animals , Dermoscopy/methods , Dermatitis/diagnosis , Dermatitis/pathology , Male , Travel , FemaleSubject(s)
Fingolimod Hydrochloride , Molluscum Contagiosum , Humans , Molluscum Contagiosum/chemically induced , Molluscum Contagiosum/drug therapy , Molluscum Contagiosum/diagnosis , Fingolimod Hydrochloride/adverse effects , Fingolimod Hydrochloride/therapeutic use , Immunosuppressive Agents/adverse effects , Immunosuppressive Agents/therapeutic use , Male , Child , FemaleABSTRACT
Skin changes associated with vitamin B12 deficiency are common. In most cases, patients present primarily with systemic involvement (eg, megaloblastic anemia and/or neurologic effects), and additional cutaneous changes related to the diagnosis are noted as incidental findings. The role of vitamin B12 deficiency in the etiology of Addisonian pigmentation has not been well studied. We discuss the importance of testing vitamin B12 levels in patients who present for evaluation of generalized hyperpigmentation. Various cutaneous changes associated with vitamin B12 deficiency also are reviewed.
Subject(s)
Hyperpigmentation/diagnosis , Skin Diseases/diagnosis , Vitamin B 12 Deficiency/complications , Adult , Anemia, Megaloblastic/etiology , Female , Humans , Hyperpigmentation/etiology , Male , Middle Aged , Skin Diseases/etiology , Skin Diseases/pathology , Vitamin B 12 Deficiency/diagnosis , Young AdultABSTRACT
Anaplastic large cell cutaneous lymphomas are clinically and pathologically heterogeneous, CD30 + (Ki-1) lymphoproliferative disorders. The importance of anaplastic lymphoma kinase (ALK) positivity is well known in the prognosis of primary systemic anaplastic large cell cutaneous lymphomas; however, the same in primary cutaneous anaplastic large cell cutaneous lymphomas is not much clear. Herein we report a 65-year-old male with an 18-month history of minimally pruritic localized nodulo-plaque lesion over lower back. Histology revealed cutaneous large cell lymphoma and immunohistochemical staining showed positivity for CD30, CD3 and ALK. The role of ALK positivity in pcALCL is discussed in this article.
