1.
Expert Opin Pharmacother
; 10(17): 2897-904, 2009 Dec.
Article
in English
| MEDLINE
| ID: mdl-19929708
ABSTRACT
Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS via glial cell attenuation. This CNS-directed anti-inflammatory activity is of potential use in the treatment of multiple sclerosis, neuropathic pain, and in the improved efficacy and safety of opioids by decreasing opioid tolerance, withdrawal and reinforcement. Its suitable pharmacokinetics and generally good tolerability make it a promising potential treatment for these conditions.
Subject(s)
Bronchodilator Agents/therapeutic use , Nervous System Diseases/drug therapy , Pyridines/therapeutic use , Respiratory Tract Diseases/drug therapy , Bronchodilator Agents/adverse effects , Bronchodilator Agents/pharmacokinetics , Bronchodilator Agents/pharmacology , Humans , Pyridines/adverse effects , Pyridines/pharmacokinetics , Pyridines/pharmacology
2.
Phys Rev B Condens Matter
; 45(1): 157-160, 1992 Jan 01.
Article
in English
| MEDLINE
| ID: mdl-10000162
3.