How Well Does Australian Animal Welfare Policy Reflect Scientific Evidence: A Case Study Approach Based on Lamb Marking.

The development and substance of animal welfare policy is subject to a range of social, cultural, economic, and scientific influences that commonly vary within and between countries. Discrepancies in policy can create confusion and mistrust among stakeholders and consumers and limit the ability to create a uniform minimum level of requirements to safeguard animal welfare, as well as create a level 'playing field' for farmers when trading with other jurisdictions. The livestock sector is receiving growing scrutiny globally for real and perceived violations of animal welfare, for example, the practice of mulesing in Australia. This article explores animal welfare legislation within Australia and how it reflects the scientific evidence surrounding routine husbandry practices in sheep, including tail docking, castration, and mulesing. While there is some variation between state and territory legislation, the most notable concern is the lack of enforceable recommendations surrounding the evidence-based use of analgesia and anaesthesia for painful husbandry procedures. The age at which these procedures are recommended to be performed is relatively consistent across Australian jurisdictions, but there is a marked difference compared to international legislation. The global context of animal welfare legislation, public perception, and producer perception of these procedures are also discussed, highlighting the difficulty of creating robust animal welfare legislation that promotes a good standard of welfare that is respected worldwide whilst being practical in an Australian setting given our unique geography and climatic conditions.

The Neuroimmune Interface and Chronic Pain Through the Lens of Production Animals.

Communication between the central nervous system (CNS) and the immune system has gained much attention for its fundamental role in the development of chronic and pathological pain in humans and rodent models. Following peripheral nerve injury, neuroimmune signaling within the CNS plays an important role in the pathophysiological changes in pain sensitivity that lead to chronic pain. In production animals, routine husbandry procedures such as tail docking and castration, often involve some degree of inflammation and peripheral nerve injury and consequently may lead to chronic pain. Our understanding of chronic pain in animals is limited by the difficulty in measuring this pathological pain state. In light of this, we have reviewed the current understanding of chronic pain in production animals. We discuss our ability to measure pain and the implications this has on animal welfare and production outcomes. Further research into the neuroimmune interface in production animals will improve our fundamental understanding of chronic pain and better inform human clinical pain management and animal husbandry practices and interventions.

Impact of Chorea on Self-care Activity, Employment, and Health-care Resource Use in Patients with Huntington's Disease.

Background: Chorea is recognized as a prototypic motor feature of Huntington's disease (HD), but its effect on health-related quality of life (HRQoL) has not been fully explored. This study describes the impact of chorea on HRQoL in patients with HD. Objective: To determine the impact of HD-related chorea on employment, self-care activities, activities of daily living, and health-care resource utilization (HCRU). Methods: Data were drawn from the Adelphi HD Disease Specific Programme, a real-world point-in-time survey of 144 neurologists and 427 patients in the United States between July and October 2017. HD patients with and without chorea were identified and examined for differences in employment status, reasons for employment changes, self-care activities, and modifications to cope with involuntary movements. Bivariate tests and inverse probability weighted regression adjustment methods were used to determine differences in outcomes between patients with and without chorea. Results: HD patients with (n=287) and without (n=140) chorea were identified. Patients with chorea were less likely to be employed full-time (16.7% vs 25.7%; P<0.04) and more likely to be on long-term sick leave (17.4% vs 5.0%; P<0.01). The onset of motor symptoms in HD-related chorea patients coincided with a change in employment status (42.7% vs 20.8%; P<0.01). Among those still working (n=145), more than two-fifths of patients with chorea required changes to their workplace and required these changes more frequently (45% vs 17%; P<0.001). HD patients with chorea required aid to help them get around significantly more frequently than those without chorea (55% vs 34%; P<0.001). Discussion: These results demonstrate that HD patients with chorea experienced greater negative impact to employment, self-care activities, and HCRU than patients without chorea experienced. These patients were more likely to stop working due to motor, cognitive, and behavioral symptoms; require modifications in the home and workplace; and need more assistance from caregivers than patients without chorea. Conclusions: Patients with HD-related chorea have greater detriments to emotional, interpersonal, and professional functioning that could be improved by reducing chorea.

The Relations Among Stress, Executive Functions, and Harsh Parenting in Mothers.

Stress is a common experience that can spillover into parenting, which in turn has important implications for child behavior. Parents' executive functioning (EF) may buffer the association between feelings of stress and parenting. However, using lower socioeconomic status (SES) and household chaos as indicators of stress, research has demonstrated inconsistent patterns with regard to this moderating role of EF. This study's first aim examined the moderating role of maternal EF on the associations between SES and household chaos, and harsh parenting. The second aim investigated the effects of experimentally induced stress on harsh parenting and whether maternal EF moderated these effects. A final sample of 101 mothers of 6 to 10-year-old children participated by completing measures of EF, household chaos, SES, and harsh parenting. Additionally, mothers were randomly assigned to either a stress group or a control group. Throughout the stress (or control) induction, mothers rated their harsh parenting in response to child misbehavior vignettes. Findings revealed that stronger EF reduced the association between household chaos and harsh parenting. There were no significant effects of SES or experimentally induced stress on harsh parenting, and EF was not a significant moderator for these stressors. These results highlight the buffering role of EF for more chronic stressors such as household chaos. SES and more acute stress, as manipulated by the TSST, at least in the current sample, may be less relevant.

Social threat attentional bias in childhood: Relations to aggression and hostile intent attributions.

The goal of this study was to examine the ways attentional bias to social threat-measured across multiple attentional processes-is related to both child aggression and a well-established cognitive correlate of aggression (namely, hostile intent attributions). A community sample of 211 children (51% male; 9-12 years; 55% Caucasian) participated in our cross-sectional correlational design. Social threat attentional bias was measured through task performance on dot-probe, attentional shifting, and temporal order judgment tasks; each task measured different attentional processes. Aggression was measured by parent- and child-report. Hostile intent attributions were measured through child responses to vignettes involving peer conflict or rejection. Attentional bias to social threat within early phases of attentional processing (i.e., attentional prioritization; stimuli presented for <200 ms in temporal order judgment task) was significantly and positively related to both aggression and hostile intent attributions. Attentional bias to social threat within attentional orienting (stimuli presented for 500 ms in dot-probe task) was positively and significantly related to hostile intent attributions. Attentional bias to social threat within attentional shifting (stimuli presented for multiple seconds) was not significantly related to aggression or hostile intent attributions. Higher levels of aggression and of hostile intent attributions were associated with an attentional bias to social threat within early, but not later, phases of attentional processing. These results suggest specificity in identifying dysfunctional attentional processes that may underlie aggression and aggression-related cognitive biases.

Maternal ADHD Symptoms and Parenting Stress: The Roles of Parenting Self-Efficacy Beliefs and Neuroticism.

OBJECTIVE: ADHD symptoms in adults are consistently related to stress in a variety of domains, although whether the link between ADHD symptoms and stress is direct, or accounted for or moderated by other variables, is little studied. We used a cross-sectional design to examine whether parenting self-efficacy accounts for the relation between maternal ADHD symptoms and parenting stress, and whether levels of maternal neuroticism moderate this relation. METHOD: A nonclinical sample of mothers of 120, six- to 12-year-old children completed surveys online. RESULTS: Maternal ADHD symptoms were associated with parenting stress, but this relation was accounted for by parenting self-efficacy beliefs. Neuroticism did not moderate the relations among these variables. Covariate analyses indicated that although parenting self-efficacy beliefs remain a robust predictor of parenting stress, the relation between maternal ADHD symptoms and parenting stress can be better accounted for by other variables. CONCLUSION: The results highlight the importance of self-efficacy beliefs and demonstrate that ADHD symptoms are not sufficient to understand the experience of parenting.

Mothers' Attributions for Positive and Negative Child Behavior: Associations With Mothers' ADHD Symptoms.

OBJECTIVE: Previous research has shown that parent attributions for child behavior have important implications on the parent-child relationship. The current study investigates whether mothers' level of ADHD symptoms is associated with their child-responsibility attributions for positive and negative child behavior. METHOD: Seventy-nine mothers of 6- to 11-year-old boys participated in this online study. Mothers completed questionnaires assessing their attributions, their ADHD symptoms, and their child's behavior. RESULTS: All mothers offered more child-responsibility attributions for positive behaviors than for negative behaviors. However, mothers with greater levels of ADHD symptoms did this to a lesser extent, blaming their child relatively more for negative behavior and giving their child relatively less credit for positive behavior. CONCLUSION: This is the first study demonstrating the association between mothers' ADHD symptoms and child-responsibility attributions. It is possible that these relatively more negative attributions could be underlying some of the parenting difficulties reported by parents with ADHD.

Parents' Attributions for Negative and Positive Child Behavior in Relation to Parenting and Child Problems.

Previous research has stressed the importance of parents' attributions and parenting for child problems. Based on social cognitive models, studies have focused on the interrelations among parents' child-responsibility attributions for negative behavior, harsh parenting, and child problems. Little is known about the extent to which child-responsibility attributions for positive behavior and other types of parenting play a role in these models. The purpose of this study was to examine whether parents' child-responsibility attributions for positive and negative child behaviors are related to child problems, and whether these relations are mediated by harsh, lax, and positive parenting. Mothers' and fathers' attributions and parenting were examined separately. A community sample of 148 couples and their 9- to 12-year-old child (50% boys) participated in the study. Mothers and children participated by completing questionnaires and a laboratory interaction task. Fathers participated by completing the same questionnaires as mothers. Harsh parenting was the only parenting variable that uniquely mediated the relations between more child-responsibility attributions for (a) negative child behaviors and child problems for both parents and (b) the inverse relation between attributions for positive child behaviors and child problems for fathers. Findings confirm the importance of harsh parenting and demonstrate the importance of parents' attributions for positive child behaviors in relation to decreasing harsh parenting and child problems. Clinically, it may be useful not only to reduce child-responsibility attributions for negative behaviors but also to increase the extent to which parents give their child credit for positive behaviors.

Parent and Child ADHD Symptoms in Relation to Parental Attitudes and Parenting: Testing the Similarity-Fit Hypothesis.

OBJECTIVE: We tested the similarity-fit hypothesis that predicts more positive parenting when both parent and child have high levels of ADHD symptoms compared to when only one does. METHOD: Mothers and fathers of 156, 5 to 13 year old sons participated (110 boys with ADHD, 46 without). Parent inattentive and hyperactive-impulsive symptoms were examined, in interaction with child ADHD, as predictors of parental tolerance, empathy, encouragement of child autonomy, and positive parenting. RESULTS: Several interactions of parent ADHD symptoms and child ADHD were detected which suggested that for parents with low levels of symptoms, the presence of child ADHD was associated with less positive parenting attitudes and behavior, but this negative relation between positive parenting and child ADHD was dampened among parents with more ADHD symptoms. CONCLUSIONS: Considered alongside the well documented parenting difficulties associated with parental ADHD, our findings suggest that parental ADHD symptoms also may help to mitigate some of the challenges facing families of children with ADHD.

Pharmacokinetics and oral bioavailability of metformin hydrochloride in healthy mixed-breed dogs.

OBJECTIVE To investigate the pharmacokinetics of metformin hydrochloride in healthy dogs after IV and oral bolus administrations and determine the oral dose of metformin that yields serum concentrations equivalent to those thought to be effective in humans. ANIMALS 7 healthy adult mixed-breed dogs. PROCEDURES Each dog was given a single dose of metformin IV (mean ± SD dose, 24.77 ± 0.60 mg/kg) or PO (mean dose, 19.14 ± 2.78 mg/kg) with a 1-week washout period between treatments. For each treatment, blood samples were collected before and at intervals up to 72 hours after metformin administration. Seventy-two hours after the crossover study, each dog was administered metformin (mean dose, 13.57 ± 0.55 mg/kg), PO, twice daily for 7 days. Blood samples were taken before treatment initiation on day 0 and immediately before the morning drug administration on days 2, 4, 6, and 7. Serum metformin concentrations were determined by means of a validated flow injection analysis-tandem mass spectrometry method. RESULTS After IV or oral administration to the 7 dogs, there was high interindividual variability in mean serum metformin concentrations over time. Mean ± SD half-life of metformin following IV administration was 20.4 ± 4.1 hours. The mean time to maximum serum concentration was 2.5 ± 0.4 hours. Mean systemic clearance and volume of distribution were 24.1 ± 7.8 mL/min/kg and 44.8 ± 23.5 L/kg, respectively. The mean oral bioavailability was 31%. CONCLUSIONS AND CLINICAL RELEVANCE The study data indicated that the general disposition pattern and bioavailability of metformin in dogs are similar to those reported for cats and humans.

Parental ADHD symptoms and parenting behaviors: A meta-analytic review.

Attention-deficit/hyperactivity disorder (ADHD) persists throughout the lifespan, and there are known impairments associated with adult ADHD. Understanding ADHD-related impairments in the parenting domain is particularly important given that the children of adults with ADHD also are likely to have ADHD, and there is potential for parenting to alter the developmental outcomes of these children. The present study quantitatively synthesizes evidence regarding the associations between parental ADHD symptoms and parenting behaviors. Across 32 studies, this meta-analysis found that parental ADHD symptoms accounted for 2.9%, 3.2%, and 0.5% of the variance of harsh, lax, and positive parenting, respectively. Greater parental ADHD symptoms were associated with less positive and more harsh and lax parenting behaviors. Variables, such as the proportion of children in the sample diagnosed with ADHD, child gender, and method/rater variance, moderated the strength of these relations. Results also suggest more similarities than differences in the associations between parenting behaviors and the two dimensions of inattention and hyperactivity/impulsivity symptoms. Overall, parental ADHD symptoms are significantly associated with parenting behaviors with effect sizes similar to the associations found between other parental psychopathologies and parenting, although the associations remain relatively small. The paper concludes with comments regarding remaining gaps in the literature that warrant further research and the clinical implications of the associations between parental ADHD symptoms and parenting.

Tracking Distraction.

OBJECTIVE: Although earlier work has shown a link between mind-wandering and ADHD symptoms, this relationship has not been further investigated by taking into account recent advances in mind-wandering research. METHOD: The present study provides a comprehensive assessment of the relationship between mind-wandering and ADHD symptomatology in an adult community sample ( N = 105, 71 females, M age = 23.1) using laboratory measures and experience sampling during daily life. RESULTS: Mind-wandering and detrimental mind-wandering were positively associated with ADHD symptoms. Meta-awareness of mind-wandering mediated the relationship between ADHD symptomatology and detrimental mind-wandering, suggesting that some of the negative consequences can be ameliorated by strategies that facilitate meta-awareness. Interestingly, participants with low ADHD scores showed a positive relationship between detrimental mind-wandering and useful mind-wandering; however, participants with high ADHD scores failed to engage in this type of "strategic" mind-wandering. CONCLUSION: These results provide new insights into the relationship between ADHD symptomatology and mind-wandering that could have important clinical implications.

Attention-Deficit/Hyperactivity Disorder Symptoms in Mothers and Fathers: Family Level Interactions in Relation to Parenting.

Previous studies linking parent ADHD symptoms to parenting have typically focused on each parent individually. To provide a broader understanding of family context, in this study, levels of inattention and hyperactivity-impulsivity in mothers and fathers were examined, both individually and in combination, in relation to negative parenting and child-rearing disagreements. Two-parent families of 5 to 13 year old boys (126 with ADHD and 53 typically developing) participated. Parents reported their own ADHD symptoms and their perceptions of child-rearing disagreements. Parenting was measured using self-, partner-, and child-reports as well as observations. Controlling for child ADHD symptoms, inattention symptoms in fathers predicted parenting difficulties. For mothers, inattention symptoms were linked to parenting problems only when fathers also had high levels of inattention. In contrast, parenting was most problematic for both mothers and fathers in families in which fathers had higher and mothers had lower levels hyperactivity-impulsivity symptoms. These results remained essentially unchanged when child externalizing behavior and mother depression and hostility were controlled, but father depression reduced the significance of some interactions. The results highlight the importance of the match between father and mother levels of symptoms, and point to differential relations of parenting to inattention and hyperactivity-impulsivity symptoms in parents.

Controlled Social Interaction Tasks to Measure Self-Perceptions: No Evidence of Positive Illusions in Boys with ADHD.

Studies have suggested that children with Attention-Deficit/Hyperactivity Disorder (ADHD) possess a Positive Illusory Bias (PIB) where they have higher self-perceptions of competence than more objective measures of their competence. However, recent research calls into question the primary methodology of these studies, that is, difference scores. This study investigated the PIB in boys with ADHD within the social domain using a novel methodology that refrains from using difference scores. Eighty-one 8- to 12-year-old boys with and without ADHD completed social interaction tasks where their actual social performance was made comparable, allowing for tests of between-group differences in self-perceptions that do not rely on difference scores. In addition, to examine whether clarity of social feedback moderates the presence of the PIB, the social tasks presented unclear, clear positive, or clear negative feedback. Boys rated how well they performed in each social interaction task, and these ratings were compared between ADHD and non-ADHD groups. Compared to the non-ADHD group, boys with ADHD did not show a PIB in their ratings of performance on the social tasks. There also was no moderation of boys' ratings by type of feedback received. In contrast, when the PIB was calculated using difference scores based on child and parent ratings of child competence, boys with ADHD showed a PIB compared to boys without ADHD. These findings call attention to the need to re-examine the phenomenon of the PIB using methodologies outside of difference scores.

The use of compensatory strategies in adults with ADHD symptoms.

This study examined the use of compensatory strategies reported by adults with ADHD symptoms and their relation to measures of functioning. Forty-nine adults (55.1 % female) completed a structured diagnostic interview to assess ADHD, and responses were coded for compensatory strategies: Adaptation, Paying Attention, Organization, External Support, and Avoidance. The majority of adults with ADHD symptoms reported using compensatory strategies, and their reported strategy use in childhood was related to their use in adulthood. No gender differences were found in the use of strategies, although Organization and External Support were used more often for inattention than for hyperactive/impulsive symptoms. Use of the compensatory strategy, Adaptation, was significantly related to measures of functioning, and the use of strategies reduced the negative relationship between ADHD symptoms and parenting difficulties. Results encourage the development of compensatory strategies among adults with ADHD symptoms, as well as provide recommendations for treatment programs.

Parenting Cognition and Affective Outcomes Following Parent Management Training: A Systematic Review.

Parent management training (PMT) is considered the gold standard in the treatment of child behavior problems. The secondary effects of these interventions, particularly on parent well-being, are infrequently studied, despite evidence that parents of children with behavior problems often experience personal difficulties. This narrative review examined the affective and parenting cognition outcomes of PMT for mothers and fathers of children ages 2-13 years, across 48 controlled treatment studies. Substantial support was found for reductions in parenting stress, and increases in perceived parenting competence following PMT. Evidence indicated fewer improvements in domains more distal from parenting, including parent depressive symptoms and marital relationship dysfunction. A number of studies suggested parent gender as a moderator of parent outcomes of PMT; however, the underrepresentation of fathers in existing research limits conclusions in this regard. Avenues for future research are highlighted to address current gaps in the literature, and to further our understanding of the ways in which both children and parents may benefit from PMT.

How student nurses can influence care quality.

With support from NHS England, NHS Improving Quality and universities, student nurses have run conferences across the country on pressure ulcer prevention. The success of the events suggests that, as emerging nurse leaders, students recognise they have a key role in educating, motivating and galvanising their peers around a shared purpose.

Marital and Coparenting Relationships: Associations With Parent and Child Symptoms of ADHD.

OBJECTIVE: To examine relations between symptoms of ADHD and reports of marital and coparenting functioning. METHOD: Parents of 8- to 12-year-old boys with (n = 26) and without (n =38) ADHD participated. RESULTS: Although mothers of children with ADHD had the highest levels of ADHD symptoms, their symptoms were typically not related to measures of the couples' functioning, particularly when controlling for family ADHD and comorbidities. Father ADHD symptoms were related to their reports of couple functioning, and fathers' ADHD symptoms were associated with their negative attributions for their wives' behavior, even with child and mother ADHD controlled. However, when fathers' depression and hostility symptoms were controlled, these were more important predictors of the attributions than ADHD symptoms. CONCLUSION: It is important to consider parental levels of ADHD symptoms in the context of other family members' symptoms as well as other forms of psychopathology.