1.
J Nucl Cardiol
; 24(3): 1071-1074, 2017 06.
Article
in English
| MEDLINE
| ID: mdl-27071999
Subject(s)
Aminophylline , Myocardial Perfusion Imaging , Caffeine , Exercise Test , Purines , Pyrazoles , Vasodilator Agents
2.
J Nucl Cardiol
; 24(1): 66-68, 2017 02.
Article
in English
| MEDLINE
| ID: mdl-26715602
3.
Science
; 299(5607): 710-2, 2003 Jan 31.
Article
in English
| MEDLINE
| ID: mdl-12560552
ABSTRACT
mahoganoid is a mouse coat-color mutation whose pigmentary phenotype and genetic interactions resemble those of Attractin (Atrn). Atrn mutations also cause spongiform neurodegeneration. Here, we show that a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion diseases but without accumulation of protease-resistant prion protein. The gene mutated in mahoganoid encodes a RING-containing protein with E3 ubiquitin ligase activity in vitro. Similarities in phenotype, expression, and genetic interactions suggest that mahoganoid and Atrn genes are part of a conserved pathway for regulated protein turnover whose function is essential for neuronal viability.