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3.
J AAPOS ; 27(1): 45-47, 2023 02.
Article in English | MEDLINE | ID: mdl-36529452

ABSTRACT

Blepharokeratoconjunctivitis (BKC) in children can have a broad clinical spectrum. Corneal involvement, including perforation, can occur in severe cases. Management aims to restore anatomical integrity and preserve visual function. We report the outcome of a novel technique, tectonic mini-Descemet stripping endothelial keratoplasty (mini-DSEK), to treat a corneal perforation secondary to BKC in a 14-year-old boy after failure to respond to cyanoacrylate glue application and multilayer amniotic membrane patch grafting. On follow-up 8 months postoperatively, the perforation remained sealed, and visual acuity was preserved. The major advantages of this technique are the avoidance of suture-related complications, reduced risk of immunological rejection, minimized postoperative refractive error, and rapid visual rehabilitation.


Subject(s)
Conjunctivitis , Corneal Diseases , Corneal Perforation , Descemet Stripping Endothelial Keratoplasty , Male , Humans , Child , Adolescent , Corneal Perforation/surgery , Endothelium, Corneal , Treatment Outcome , Descemet Stripping Endothelial Keratoplasty/methods , Corneal Diseases/surgery
4.
Eur J Ophthalmol ; 31(1_suppl): 11-15, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33884920

ABSTRACT

AIM: To report a case of ocular cicatricial pemphigoid caused by levamisole-adulterated cocaine. METHODS: Case report. RESULTS: A 54-year-old woman with multi-systemic levamisole-induced vasculitis which triggered bilateral cicatrizing conjunctivitis refractory to conventional immunosuppressants due to continued cocaine misuse. CONCLUSION: Levamisole-induced vasculitis is a significant public health issue due to its popularity as an adulterant to cocaine. Our report suggests that levamisole caused vasculitis and ocular cicatricial pemphigoid in this case. Ocular manifestation of this syndrome is rare.


Subject(s)
Adjuvants, Immunologic/toxicity , Cocaine-Related Disorders/complications , Cocaine/adverse effects , Conjunctivitis/chemically induced , Drug Contamination , Levamisole/toxicity , Pemphigoid, Benign Mucous Membrane/chemically induced , Cicatrix/complications , Combined Modality Therapy , Conjunctivitis/diagnosis , Conjunctivitis/drug therapy , Female , Humans , Immunosuppressive Agents , Middle Aged , Pemphigoid, Benign Mucous Membrane/diagnosis , Pemphigoid, Benign Mucous Membrane/drug therapy
5.
Cornea ; 38(10): 1332-1335, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31219884

ABSTRACT

PURPOSE: To present a case series of patients with corneal and scleral changes associated with the use of skin-lightening creams. This is the first report of corneal changes with these widely available creams. METHODS: Three patients of West African origin presented with strikingly similar skin, corneal, and scleral changes and were found to have all been using skin-lightening creams containing hydroquinone. Histopathology was obtained for 1 patient. RESULTS: Three patients were referred to the corneal clinics of 2 hospitals with corneal changes and a history of blurred vision for 1 to 3 years. There was a 60-year-old woman from Nigeria and a 68-year-old woman and a 73-year-old man both from Ghana. All 3 had been using skin-lightening lotions containing hydroquinone on their faces for between 3 and 15 years and had black-blue facial pigmentation of exogenous ochronosis, a recognized complication of these creams. Their corneas all had horizontal striae radiating across the posterior corneas with scleral thinning and plaques. Linear brown epithelial pigmentation was observed within the lower third of the corneas. Biopsy of the sclera in 1 patient showed ochronosis. CONCLUSIONS: We present previously unreported eye changes associated with the use of skin-lightening creams containing hydroquinone, with a triad of signs: posterior corneal striae radiating from 3 o'clock to 9 o'clock, thinning and plaques in the sclera, and a normal endothelial cell count. Similar pathological changes are seen in exogenous ochronosis, a recognized skin complication of hydroquinone, are seen in the sclera.


Subject(s)
Alkaptonuria/diagnosis , Cornea/pathology , Hydroquinones/adverse effects , Ochronosis/diagnosis , Sclera/pathology , Administration, Topical , Aged , Alkaptonuria/chemically induced , Biopsy , Cornea/drug effects , Dermatologic Agents/administration & dosage , Dermatologic Agents/adverse effects , Female , Humans , Hydroquinones/administration & dosage , Male , Middle Aged , Ochronosis/chemically induced , Sclera/drug effects
6.
Ophthalmology ; 123(5): 991-9, 2016 05.
Article in English | MEDLINE | ID: mdl-26876697

ABSTRACT

PURPOSE: To determine the frequency of meibomian gland dysfunction (MGD) in children with epidermolysis bullosa (EB). DESIGN: Hospital-based cross-sectional study. PARTICIPANTS: One hundred five children with different forms of EB. METHODS: Prospective ophthalmic examination of children with EB presenting over seventeen months including meibomian gland assessment using a recognized classification. MAIN OUTCOME MEASURES: Frequency of MGD. RESULTS: One hundred five children were recruited, 8.6% with junctional EB, 34.3% with simplex EB, 34.3% with autosomal recessive dystrophic EB, and 22.9% autosomal dominant dystrophic EB. Mean age was 7.42 years (range, 0.08-17.75 years). Ninety-two children (87.62%) demonstrated 1 or more features of MGD. CONCLUSIONS: Most children with EB exhibit signs of MGD. To the best of our knowledge, this is the first prospective ocular surface evaluation in children with EB to include lid margin evaluation using a recognized classification system. Our findings help explain some of the ocular surface anomalies seen in children with EB.


Subject(s)
Epidermolysis Bullosa/epidemiology , Eyelid Diseases/epidemiology , Meibomian Glands/pathology , Adolescent , Child , Child, Preschool , Cross-Sectional Studies , Epidermolysis Bullosa/classification , Epidermolysis Bullosa/diagnosis , Eyelid Diseases/diagnosis , Female , Humans , Infant , Male , Prospective Studies , Referral and Consultation , United Kingdom/epidemiology
7.
Br J Ophthalmol ; 97(9): 1129-33, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23821656

ABSTRACT

OBJECTIVE: To perform an objective evaluation of the non-invasive tear break-up time (NITBUT) and lipid layer interferometry in normal children. METHODS: Children with no known ocular surface disease or anterior segment abnormality were evaluated. We excluded patients with disorders affecting lid margins or tear film composition. NITBUT and lipid layer interferometry were performed using a Keeler tearscope mounted on a slit lamp. The time from eye opening to the first distortion of the grid was noted. The average of three readings was taken as the NITBUT. RESULTS: Thirty-six children (71 eyes) were included (mean age 7.64 years, range 2.16-15.83 years). Mean NITBUT was 21.76 ± 4.06 s (range 14.9-30.95). This is significantly higher in comparison to recent adult studies utilising the tearscope. Twenty-four children allowed tearscope lipid layer interferometry. Eighteen demonstrated grade 1 and six demonstrated grade 2. These grades are within the normal tear film range. CONCLUSIONS: To our knowledge, this prospective study is the first to evaluate NITBUT in normal children. The results demonstrate that NITBUT is greater in children in comparison to adults. These normative data are a useful benchmark for further research into tear film instability in children.


Subject(s)
Lipids , Tears/metabolism , Adolescent , Child , Child, Preschool , Female , Humans , Interferometry , Male , Prospective Studies
8.
J Pediatr Ophthalmol Strabismus ; 50(5): 290-5, 2013.
Article in English | MEDLINE | ID: mdl-23705592

ABSTRACT

PURPOSE: To determine whether children tolerate cyclopentolate 1% spray better than drops and to assess the adequacy of cycloplegia achieved by spray for objective refraction. METHODS: The effects of cyclopentolate 1% drops and spray on distress levels were assessed prospectively using a guardian questionnaire in consecutive patients 10 years of age or younger. Distress was graded at various points during the appointment using a Likert scale of 1 to 10 (1 = no distress, 10 = severe distress). The adequacy of cycloplegia in children receiving cyclopentolate spray and the waiting times were assessed via a Likert questionnaire completed by the examining physician. RESULTS: The guardians of 72 and 77 children who received cyclopentolate 1% drops or spray, respectively, completed the questionnaire. The children were divided in three age groups: 1 to 4 years, 5 to 7 years, and 8 to 10 years. Children 7 years or younger were significantly less distressed by administration of cyclopentolate 1% spray (P < .005). There was no statistical difference in distress levels in children older than 7 years (P = .9719). Thirteen of the 77 children who received cyclopentolate 1% spray did not have adequate cycloplegia to allow objective refraction. CONCLUSION: The results demonstrate cyclopentolate 1% spray is less distressing at the time of administration than cyclopentolate 1% drops for children 7 years or younger. However, the cycloplegia achieved is not adequate in a high percentage of children.


Subject(s)
Aerosols , Cyclopentolate/administration & dosage , Mydriatics/administration & dosage , Ophthalmic Solutions , Pupil/drug effects , Child , Child, Preschool , Female , Humans , Infant , Male , Outpatients , Patient Satisfaction , Prospective Studies , Refraction, Ocular , Surveys and Questionnaires , Vision Tests
9.
J Plast Reconstr Aesthet Surg ; 64(1): 4-8, 2011 Jan.
Article in English | MEDLINE | ID: mdl-20392680

ABSTRACT

Body dysmorphic disorder (BDD) is a disabling preoccupation with a slight or an imagined defect in appearance. It is recognised in some patients who present to the plastic surgeon requesting multiple cosmetic procedures. Very rarely, BDD patients may wish for amputation of a healthy limb and may even mutilate themselves deliberately in order to necessitate amputation. These patients pose a diagnostic challenge as BDD is uncommon and they are often uncooperative whilst appearing mentally sound. Furthermore, they raise difficult ethical and legal issues for the surgeon. Although there is some guidance for the management of BDD patients seeking elective amputation, there is currently none for the management of those who present in the emergency setting. Illustrated by the case of a man who, having failed to find a complicit surgeon, attempted self-amputation of the hand, we review the relevant ethical, legal and management issues with advice by the British Medical Association and General Medical Council.


Subject(s)
Amputation, Traumatic/psychology , Body Dysmorphic Disorders/surgery , Plastic Surgery Procedures/methods , Self Mutilation/surgery , Adult , Amputation, Traumatic/etiology , Body Dysmorphic Disorders/complications , Body Dysmorphic Disorders/diagnosis , Body Dysmorphic Disorders/psychology , Body Image , Emergency Service, Hospital , Hand , Humans , Male , Prognosis , Risk Assessment , Self Mutilation/diagnosis , Self Mutilation/psychology , Self-Injurious Behavior/complications , Self-Injurious Behavior/psychology , Treatment Outcome , United Kingdom
10.
Am Orthopt J ; 59: 76-83, 2009.
Article in English | MEDLINE | ID: mdl-21149192

ABSTRACT

BACKGROUND AND PURPOSE: Epidermolysis bullosa (EB) is a genetic disorder resulting in blistering of the skin and mucous membranes. While ocular surface complications in EB patients are well documented, there are no reports* on the incidence of refractive errors and orthoptic problems in these patients. PATIENTS AND METHODS: Fifty-five consecutive EB patients underwent examination including visual acuity, cover test, ocular motility and assessment of binocular single vision, cycloplegic refraction, and fundus examination. RESULTS: Twenty-one of the 55 patients (38%) had reduced visual acuity (0.3 logMAR or less) in at least one eye, and 13 / 55 (24%) had bilaterally reduced visual acuity. Twenty-nine percent of patients had refractive errors; 20% hypermetropic, 5% myopic, 16% astigmatism, and 11% anisometropic. Fifteen percent of patients had a constant or intermittent tropia; 9% exotropia and 4% esotropia. Thirteen percent of patients had a significant phoria (> 10(Δ)); all were exophoric. Sixteen percent had convergence insufficiency. This cohort of EB patients demonstrated a high prevalence of reduced visual acuity, strabismus and refractive errors compared with normal pediatric data from the literature. CONCLUSIONS: A large proportion of patients with EB across the subgroups have clinically significant refractive errors and strabismus. In view of the improved survival of EB patients, visual morbidity is of increasing importance. This study highlights the need for careful orthoptic and ophthalmic surveillance of children with EB.

11.
Ophthalmology ; 114(12): 2271-80, 2007 Dec.
Article in English | MEDLINE | ID: mdl-18054641

ABSTRACT

OBJECTIVE: To describe the cause, management, and effect of chronic blepharokeratoconjunctivitis (BKC) on the cornea and visual function in children. DESIGN: Noncomparative, interventional, retrospective case series. PARTICIPANTS: Twenty-seven children with BKC. METHODS: Presenting age, best-corrected visual acuity (BCVA), refractive error, and any corneal or eyelid pathologic features were recorded. Treatment included modified lid hygiene, topical antibiotics, and steroids. Systemic therapy included oral antibiotics and, from 2003 onward, flaxseed oil as an alternative to long-term antibiotics. Amblyopia therapy included refractive correction, occlusion, or atropine therapy. MAIN OUTCOME MEASURES: Corneal and eyelid status, visual acuity (VA), and refractive error at final examination. RESULTS: Mean age at presentation was 6.9 years (range, 7 months-15.9 years), and mean follow-up was 2.3 years (range, 5 months-6.1 years). All patients had discomfort, conjunctival injection, and signs of posterior blepharitis at presentation. Photophobia was reported in 14 patients (52%), whereas anterior eyelid inflammation was noted in 6 (22%). Acne rosacea was confirmed in 3 patients (11%). Corneal involvement occurred in 44 eyes (81%), and a history of recurrent chalazia was seen in 18 patients (67%). Median monocular BCVAs in affected eyes were 0.28 logarithm of the minimum angle of resolution (logMAR) units (interquartile range [IqR], 0.02-0.40) at presentation and 0.02 logMAR units (IqR, 0.00-0.18) at last visit. Best-corrected VA improved in 70% of affected eyes and remained unchanged in 30%. Superimposed amblyopia was present and treated in 15 patients (48%). All 8 patients (20%) who failed to achieve VA of 0.2 logMAR units or better at the final examination had bilateral corneal involvement at presentation. One child experienced a systemic side effect from oral antibiotics. No child had significant side effects from topical treatment. Twelve patients (44%) received flaxseed oil as part of their tapering regimen. A 2-year lag between symptom onset and treatment resulted, on average, in a reduction of 0.06 logMAR units of VA (95% confidence interval, 0.00-0.12; P = 0.054). CONCLUSIONS: These findings suggest that visual loss may be significant in BKC and that delayed treatment may result in decreased final BCVA. Adequate management needs both topical and systemic treatment. Flaxseed oil may be an effective antiinflammatory nutritional therapy alternative to long-term antibiotics.


Subject(s)
Blepharitis/physiopathology , Cornea/physiopathology , Keratoconjunctivitis/physiopathology , Vision Disorders/physiopathology , Visual Acuity/physiology , Adolescent , Amblyopia/physiopathology , Amblyopia/therapy , Anti-Bacterial Agents/therapeutic use , Blepharitis/complications , Blepharitis/therapy , Child , Child, Preschool , Chronic Disease , Drug Therapy, Combination , Female , Follow-Up Studies , Glucocorticoids/therapeutic use , Humans , Infant , Keratoconjunctivitis/complications , Keratoconjunctivitis/therapy , Male , Refractive Errors/physiopathology , Refractive Errors/therapy , Retrospective Studies
12.
Arch Ophthalmol ; 124(10): 1435-40, 2006 Oct.
Article in English | MEDLINE | ID: mdl-17030711

ABSTRACT

OBJECTIVE: To report our pediatric experience with amniotic membrane transplantation for ocular surface and forniceal reconstruction. METHODS: Retrospective case review of children who underwent superficial keratectomy, symblepharon lysis, and forniceal reconstruction using amniotic membrane transplantation. The underlying diagnosis, visual acuity, level of discomfort at first and last visits, and surgical details were noted. RESULTS: Four patients (5 eyes) were included. Two patients had epidermolysis bullosa (1 recessive dystrophic and 1 junctional), 1 had laryngo-onychocutaneous syndrome, and 1 had measles-related keratitis and was positive for human immunodeficiency virus. Their mean age when initially seen was 8.7 years (age range, 4-16 years), and mean follow-up was 18.25 months (range, 12-29 months). The mean visual acuity preoperatively was 1.1 logMAR (logarithm of the minimum angle of resolution) (range, 1-1.3), and postoperatively was 0.7 (range, 0.2-1.2). All patients experienced increased ocular comfort with anatomical restoration of corneal and conjunctival surfaces. Visual acuity improved in 3 eyes. Only the patient with laryngo-onychocutaneous syndrome had recurrence of granuloma, at 9 months after surgery. CONCLUSION: Amniotic membrane transplantation with symblepharon lysis is effective for ocular surface reconstruction in the management of epidermolysis bullosa and other conditions that cause corneal scarring and symblepharon in children. In this small series, children with epidermolysis bullosa fared better and the effects of surgery lasted longer compared with patients with other causes of symblepharon and massive pannus.


Subject(s)
Amnion/transplantation , Conjunctival Diseases/surgery , Corneal Diseases/surgery , Eyelid Diseases/surgery , Adolescent , Child , Child, Preschool , Female , Humans , Male , Ophthalmologic Surgical Procedures , Prognosis , Plastic Surgery Procedures , Retrospective Studies , Suture Techniques , Visual Acuity
14.
Int Wound J ; 1(4): 225-30, 2004 Dec.
Article in English | MEDLINE | ID: mdl-16722871

ABSTRACT

Better care for patients and improved health care depends on the availability of good information which is accessible when and where it is needed. The development of technology, more specifically the Internet, has expanded the means whereby information can be acquired and transmitted over large distances enabling the concept of telemedicine to become a reality. Telemedicine, defined as the practise of medicine at a distance, encompasses diagnosis, education and treatment. It is a technology that many thought would expand rapidly and change the face of medicine. However, this has not happened and during the last decade although certain telemedicine applications, such as video-consulting and teleradiology, have matured to become essential health care services in some countries, others, such as telepathology, remain the subject of intensive research effort. Telemedicine can be used in almost any medical specialty although the specialties best suited are those with a high visual component. Wound healing and wound management is thus a prime candidate for telemedicine. Development of a suitable telemedical system in this field could have a significant effect on wound care in the community, tertiary referral patterns and hospital admission rates.


Subject(s)
Telemedicine/economics , Telemedicine/methods , Wound Healing/physiology , Wounds and Injuries/diagnosis , Wounds and Injuries/therapy , Computer Communication Networks , Cost Savings , Cost-Benefit Analysis , Female , Humans , Male , Remote Consultation/economics , Remote Consultation/methods , Sensitivity and Specificity , Teleradiology/economics , Teleradiology/methods , United Kingdom
15.
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