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Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease.
Marinho, Cláudio R F; Nuñez-Apaza, Luis N; Bortoluci, Karina R; Bombeiro, André L; Bucci, Daniella Z; Grisotto, Marcos G; Sardinha, Luiz R; Jorquera, Christian E; Lira, Sergio; Lima, Maria Regina D'Império; Alvarez, José M.
Microbes Infect ; 11(13): 1037-45, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19660570

ABSTRACT

The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease.


Subject(s)
Chagas Disease/parasitology , Trypanosoma cruzi/physiology , Animals , Chagas Disease/immunology , Chronic Disease , Disease Models, Animal , Host-Parasite Interactions , Mice , Parasitemia/immunology , Parasitemia/parasitology , Trypanosoma cruzi/pathogenicity
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