ABSTRACT
Introduction. Triple-negative cancers (TNC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or human epidermal grow factor, receptor type 2. Herceptin (HER2). They tend to be more aggressive; often being diagnosed in young patients, sometimes as interval cancers, they can grow to be large in size and patients frequently present initially with axillary metastases. They show a worse prognosis compared to other breast cancer tumors, with an increased risk of distant recurrence and death, especially in the first 5 years after diagnosis. Patients and methods. We conducted a descriptive, retrospective observational study of TNC cases diagnosed at our institution between March 2005 and June 2012 in order to identify their imaging features. Results. TNC may not be seen on mammography (Mx) if the parenchyma is dense (ACR types 3 and 4), mainly because they appear as masses or focal asymmetries without microcalcifications. Both on mammography and ultrasound (US) they can evoke a benign lesion. On US studies they frequently manifest as a solid single nodule, markedly hypoechoic with posterior acoustic enhancement and well-defined contours. They appear hypo/ avascular on color Doppler examinations (or vascularized in the periphery without central vessels) and various afferent pedicles may be present. Magnetic resonance imaging (MRI) clearly identifies suspicious lesions with some characteristic features: mass preferably with posterior and prepectoral location, markedly hyperintense on T2- weighted images with a ring-like pattern of contrast agent uptake, presenting washout curve, sometimes with septa increased uptake in the lesion center. Conclusion. Triple receptor-negative cancers often exhibit imaging features that distinguish them from other types of tumors.
Introducción. Los cánceres triple negativo (CTN) son aquellos que no presentan receptores de estrógeno, progesterona ni human epidermal grow factor, receptor type 2. Herceptin (HER2). Tienden a ser más agresivos; a menudo se diagnostican en pacientes jóvenes, a veces como cánceres de intervalo, llegan a ser de gran tamaño y más frecuentemente presentan metástasis axilares al momento del diagnóstico. Su pronóstico es peor que otros cánceres mamarios, existiendo una mayor probabilidad de recurrencia a distancia y de muerte, especialmente en los primeros 5 años. Pacientes y métodos. Se efectuó una revisión retrospectiva descriptiva de los casos de CTN diagnosticados en nuestra institución (periodo entre marzo de 2005 y junio de 2012) con el fin de identificar sus características imaginológicas. Resultados. Los CTN pueden quedar ocultos en mamografía (Mx) si el parénquima es denso (tipo ACR 3 y 4), puesto que aparecen principalmente como masas o asimetrías focales, sin microcalcificaciones. Tanto en Mx como en ultrasonido (US) pueden evocar una lesión de morfología benigna. En US se manifiestan frecuentemente como un nódulo sólido único, marcadamente hipoecogénico con refuerzo posterior, de contornos bastante circunscritos y que aparece hipo/avascular al Doppler color (o vascularizado en la periferia sin vasos centrales) y varios pedículos aferentes. La resonancia magnética (RM) identifica hallazgos claramente sospechosos con algunos elementos característicos: masa cuya localización es preferentemente posterior, pre-pectoral, marcadamente hiperintensa en T2 que capta el contraste en anillo y presenta curva de lavado, a veces con septos hipercaptantes en el centro de la lesión. Conclusión. Los CTN presentan a menudo características en imágenes que los diferencian de otros tipos de tumores.
Subject(s)
Aged, 80 and over , Breast Neoplasms/diagnosis , Breast Neoplasms/epidemiology , Ultrasonography, Mammary , Retrospective Studies , Age Factors , Magnetic Resonance Imaging , Mammography , Breast Neoplasms/pathologyABSTRACT
PURPOSE: To report on the occurrence of histology-proven sympathetic ophthalmia in a patient with VATER association and persisting hyperplastic primary vitreous (PHPV) after a cyclodestructive procedure was performed to treat secondary angle-closure glaucoma. METHODS: The left eye of a 13-year-old boy with VATER association was microphthalmic from birth and had been diagnosed with PHPV at age 1 year. It developed iris neovascularization and secondary angle-closure glaucoma, which was treated by combined cyclocryocoagulation and cyclophotocoagulation. Six weeks later, a bilateral fibrinous iritis developed. Despite intensive topical and systemic steroid treatment, the iritis persisted so that the left blind eye was enucleated. RESULTS: Histology of the enucleated eye showed a marked intraocular inflammation with lymphocytes, epithelioid cells, and multinuclear giant cells grouped around remnants of melanin-bearing cells. CONCLUSIONS: Sympathetic ophthalmia may occur in patients with VATER association and PHPV after a secondary angle-closure glaucoma is treated by a combined cyclocryocoagulation and cyclophotocoagulation.
Subject(s)
Abnormalities, Multiple , Cryosurgery/adverse effects , Eye Abnormalities/complications , Glaucoma, Angle-Closure/surgery , Laser Coagulation/adverse effects , Ophthalmia, Sympathetic/etiology , Vitreous Body/abnormalities , Adolescent , Ciliary Body/surgery , Eye Abnormalities/diagnosis , Eye Enucleation , Humans , Male , Ophthalmia, Sympathetic/diagnosis , Vitreous Body/pathologyABSTRACT
PURPOSE: To report on the occurrence of histology-proven sympathetic ophthalmia in a patient with VATER association and persisting hyperplastic primary vitreous (PHPV) after a cyclodestructive procedure was performed to treat secondary angle-closure glaucoma. METHODS: The left eye of a 13-year-old boy with VATER association was microphthalmic from birth and had been diagnosed with PHPV at age 1 year. It developed iris neovascularization and secondary angle-closure glaucoma, which was treated by combined cyclocryocoagulation and cyclophotocoagulation. Six weeks later, a bilateral fibrinous iritis developed. Despite intensive topical and systemic steroid treatment, the iritis persisted so that the left blind eye was enucleated. RESULTS: Histology of the enucleated eye showed a marked intraocular inflammation with lymphocytes, epithelioid cells, and multinuclear giant cells grouped around remnants of melanin-bearing cells. CONCLUSIONS: Sympathetic ophthalmia may occur in patients with VATER association and PHPV after a secondary angle-closure glaucoma is treated by a combined cyclocryocoagulation and cyclophotocoagulation. (Eur J Ophthalmol 2006; 16: 171-172).
ABSTRACT
108 world class athletes (54 males, 54 females) practicing modern pentathlon had been interviewed about their individual training and competition efforts as well as their sports related injuries, damages and diseases in the last world cup season using a standardized empirical questionnaire. The mean training extent was about 25 hours per week, the mean number of national and international competitions athletes made was 9, especially concerning swimming and running. Mean number of health threatening incidents of each athlete had been 2 with 41% diseases such as otitis and pharyngitis, 23% injuries such as contusions and distortions and 33% damages such as tendinitis, periostitis and strains. Head and neck involvement were more frequent than those of pelvis and the lower extremities. Training efforts were the most frequent reasons for health threatening events (84%), especially concerning diseases and damages, whereas most of the injuries happened during competitions (p<.01). Most of the injuries happened practicing horse riding during competitions (9%). Running was the most frequent reason for damages, whereas horse riding is the leading cause for injuries, furthermore damages and injuries are typical for fencing. Swimming is often associated with diseases. In contrary shooting did not show typically affiliated health threatening events. The incidence of health threatening incidents concerning world class athletes practicing modern pentathlon is quite low. Especially running and swimming combined with a high training extent empirically predisposed to suffer from damages and diseases. Horse riding with a quite low training extent and fencing show a higher incidence of injuries. From the training-methodological point of view the training extent should not be too extended. Due to a high number of diseases it may be profitable to be in attendance of an inner medicine physician.
Subject(s)
Athletic Injuries/epidemiology , Competitive Behavior , Otitis/epidemiology , Pharyngitis/epidemiology , Physical Endurance , Sports/statistics & numerical data , Adult , Athletic Injuries/etiology , Competitive Behavior/classification , Cross-Sectional Studies , Female , Germany/epidemiology , Humans , Incidence , Male , Otitis/etiology , Pharyngitis/etiology , Physical Education and Training/statistics & numerical data , Retrospective Studies , Risk FactorsABSTRACT
Presentamos el caso clínico de gemela unida o siamés toracoonfalópago. Se destaca el diagnóstico prenatal, el manejo clínico y la resolución planificada del parto por operación cesárea, contando con un apoyo neonatológico de cuidado intensivo. Se da a conocer una revisión bibliográfica nacional e internacional.
A case of female thoraco omphalopagus conjoined twins is described. Antenatal diagnosis procedures, obstetric management and rational planning by cesarean section with neonatal intesive care facilities are discussed. A review reports national and international is presented.