ABSTRACT
BACKGROUND: Staging of liver fibrosis traditionally relied on liver histology; however, transient elastography (TE) and more recently two-dimensional shear wave elastography (2D-SWE) evolved to noninvasive alternatives. Hence, we evaluated the diagnostic accuracy of 2D-SWE assessed by the Canon Aplio i800 ultrasound system using liver biopsy as reference and compared the performance to TE. METHODS: In total, 108 adult patients with chronic liver disease undergoing liver biopsy, 2D-SWE and TE were enrolled prospectively at the University Hospital Zurich. Diagnostic accuracies were evaluated using the area under the receiver operating characteristic (AUROC) analysis, and optimal cut-off values by Youden's index. RESULTS: Diagnostic accuracy of 2D-SWE was good for significant (≥F2; AUROC 85.2%, 95% confidence interval (95%CI):76.2-91.2%) as well as severe fibrosis (≥F3; AUROC 86.8%, 95%CI: 78.1-92.4%) and excellent for cirrhosis (AUROC 95.6%, 95%CI: 89.9-98.1%), compared to histology. TE performed equally well (significant fibrosis: 87.5%, 95%CI: 77.7-93.3%; severe fibrosis: 89.7%, 95%CI: 82.0-94.3%; cirrhosis: 96%, 95%CI: 90.4-98.4%), and accuracy was not statistically different to 2D-SWE. 2D-SWE optimal cut-off values were 6.5, 9.8 and 13.1 kPa for significant fibrosis, severe fibrosis and cirrhosis, respectively. CONCLUSIONS: Performance of 2D-SWE was good to excellent and well comparable with TE, supporting the application of this 2D-SWE system in the diagnostic workup of chronic liver disease.
Subject(s)
Elasticity Imaging Techniques , Liver Diseases , Adult , Humans , Elasticity Imaging Techniques/methods , Liver Cirrhosis/diagnostic imaging , Liver Cirrhosis/pathology , Liver/diagnostic imaging , Liver/pathology , Fibrosis , BiopsyABSTRACT
Diseases as a `Stumbling Block` - a Case of Multimorbidity in Clinical Practice Abstract. Here we report on a 83 year-old patient with cardiac syncope and consecutive traumatic brain injury with intracranial haemorrhage receiving anticoagulation for recurrent pulmonary embolism: a 'medical dilemma' due to the syncope with consecutive traumatic event and the underlying condition. A pre-existing underlying cardiac disease was identified as the cause of the syncope and the intracranial haemorrhage was most likely due to oral anticoagulation for recurrent pulmonary embolisms. The intracranial bleeding inhibited an optimal management of the underlying cardiac condition and the patient deceased shortly thereafter.
Subject(s)
Anticoagulants/adverse effects , Head Injuries, Closed/diagnosis , Intracranial Hemorrhage, Traumatic/chemically induced , Intracranial Hemorrhage, Traumatic/diagnosis , Pulmonary Embolism/drug therapy , Syncope/diagnosis , Accidental Falls , Aged, 80 and over , Anticoagulants/therapeutic use , Aortic Valve Stenosis/complications , Aortic Valve Stenosis/diagnosis , Atrioventricular Block/complications , Atrioventricular Block/diagnosis , Contraindications , Diagnosis, Differential , Fatal Outcome , Head Injuries, Closed/therapy , Humans , Interdisciplinary Communication , Intersectoral Collaboration , Intracranial Hemorrhage, Traumatic/therapy , Male , Multimorbidity , Risk Factors , Syncope/therapy , Treatment RefusalABSTRACT
Rabies is one of the oldest known infectious diseases and certainly one of the most feared because of its impressive course. Despite continuous improvement in medical treatment, the disease continues to be almost always fatal after onset of symptoms. Due to urbanization, rabies has lately somewhat disappeared from the public focus in Central Europe. Because of the remaining high number of fatal cases due to rabies infection worldwide and the persistent risk of contagion on holiday or within Switzerland, e.g. due to illegal import of infected animals, the disease is becoming a frequent topic in the media again.