[Summary Of Admissions To The Bamako Dermatology Hospital]. / Bilan Des Admissions A l'Hôpital De Dermatologie De Bamako.

OBJECTIVE: It was to take stock of the dermatological conditions managed within the hospital over a period of five years. PATIENTS AND METHODS: Retrospective and descriptive study performed from January 2015 to December 2019 at the Bamako Dermatology Hospital, based on the records of patients received in consultation. RESULTS: During the period, 6,322 new consultations were recorded. The mean age was 42 ± 12.5 years with extremes of two months and 82 years. The sex ratio was 0.6. The majority of our patients (76.1%) came directly from home. Socio-professionally, the patients were mainly peasants (45%), housewives (23.9%) and workers (12%). Among the 6,322 consultants, 27.1% were hospitalized. In terms of diagnosis, skin conditions were dominated by infections (56.1%), followed by allergies (15.4%); system diseases (12.0%); genetic dermatoses (7.5%) and tumor dermatoses (5.2%). The average length of hospital stay was 46 ± 18.7 days in adults and 21 ± 11.6 days in children. CONCLUSION: This study made it possible to identify the skin conditions subject to consultation in dermatology which are dominated by infections and allergies.

OBJECTIF: Faire le bilan des différentes affections dermatologiques prises en charge au sein de l'hôpital sur une période de cinq années. PATIENTS ET MÉTHODES: Etude rétrospective et descriptive menée de janvier 2015 à décembre 2019 à l'Hôpital de Dermatologie de Bamako, basée sur les dossiers des patients reçus en consultation. RÉSULTATS: Durant la période, 6322 nouvelles consultations ont été enregistrées. La moyenne d'âge était de 42±12,5 ans avec des extrêmes de deux mois et 82 ans. Le sex-ratio était de 0,6. La majorité de nos patients (76,1%) était venue directement de la maison. Sur le plan socioprofessionnel, les patients étaient surtout des paysans (45%), des ménagères (23,9%) et des ouvriers (12%). Parmi les 6322 consultants, 27,1% ont été hospitalisés. Sur le plan diagnostique, les affections cutanées étaient dominées par les infections (56,1%), suivies des allergies (15,4%) ; les maladies de système (12,0%) ; les dermatoses génétiques (7,5%) et celles tumorales (5,2%). La durée moyenne d'hospitalisation était de 46±18,7 jours chez les adultes et de 21±11,6 jours chez les enfants. CONCLUSION: Cette étude a permis de recenser les affections cutanées faisant objet de consultation en dermatologie qui sont dominées par les infections et les allergies.

GIANT BLADDER STONE IN A PATIENT WITH TUMOR OF THE BLADDER: A RARE CO-MORBIDITY.

Bladder stones are considered carcinogenic factor for bladder cancer. Concomitant association between giant bladder stone and bladder cancer is rare. We report a case of giant bladder stone complicated by bladder cancer. Bladder cancer was discovered fortuitously. This association of bladder growth necessitated biopsy of the bladder for histopathological study during cystolithotomy.

[Characteristics of the patients "lost to follow-up" and determining factors of loss to follow-up to patients living with HIV at Ouagadougou, Burkina Faso]. / Caractéristiques des patients "perdus de vue" et facteurs déterminants de la perte de vue au cours du suivi des patients infectés par le VIH à Ouagadougou, Burkina Faso.

The objective of this study is to describe the characteristics of the patients "lost to follow-up" and determining factors of lost to follow-up at the patients infected by HIV. This is a descriptive and analytical retrospective study made on patients with or not by HAART, registered in the Day hospital of Ouagadougou. Of 5118 adult patients studied, 402 (7.9%) lost to follow-up. Among these patients, 340 (84.5%) had an unknown vital status, 28 (7%) were alive and 34 (8.5%) died. Mean age was 37.5 years. After active research, 16 from 21 patients under HAART were in treatment interruption. The main factors associated with the loss of follow-up were: no schooling (p=0,008), residing outside the capital (p=0,002) and being infected with HIV2 (p< 10(-3)). The phenomenon of loss of follow-up is important and concerned mainly not informed patients.

Intrarectal pharmacokinetics of two formulations of quinine in children with falciparum malaria.

OBJECTIVE: To compare the intrarectal bioavailabilities of two parenteral formulations of quinine most available in French- (Cinchona alkaloid mixture) and English (hydrochloride salt) -speaking areas of Africa. METHODS: The pharmacokinetics of quinine was investigated in four groups of 12 children with acute Plasmodium falciparum malaria receiving 8 mg/kg quinine base every 8 h either as hydrochloride salt or Cinchona alkaloid mixture by a slow 4-h intravenous infusion or intrarectal administration. Body temperature and parasitaemia were monitored, and blood quinine concentrations were measured by means of high-performance liquid chromatography. RESULTS: At 72 h, all the children were aparasitaemic and apyretic. Quinine C(max) values were higher after intravenous infusion of the hydrochloride salt and Cinchona alkaloid mixture (6.9+/-1.9 micro g/ml and 5.2+/-1.3 micro g/ml) than after intrarectal administration (3.5+/-1.4 micro g/ml and 3.1+/-1.6 micro g/ml), but t(max) values were similar (3.6+/-1.5, 4.2+/-1.0, 4.0+/-1.9, and 4.7+/-2.0 h, respectively). Intrarectal relative bioavailabilities of hydrochloride salt solution (57%) and Cinchona alkaloid mixture (62%) were similar. CONCLUSION: Whatever the parenteral formulation of quinine, the blood concentration-time profiles of quinine were similar after intrarectal administration. Intrarectal administration of hydrochloride salt solution is a possible mode of quinine delivery in remote rural areas of Africa.