ABSTRACT
Influence of aqueous and aqueous-ethanol extracts of meadowsweet (Filipendula vulgaris) on the behavior of albino mice in anxiety models has been studied. It is established that the aqueous and 95% aqueous ethanol extracts of meadowsweet produce the most expressed anxiolytic action in the elevated plus-maze, open field, and emotional reaction tests. The anxiolytic activity of these extracts exceeds that of the reference valerian extract.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety/drug therapy , Behavior, Animal/drug effects , Filipendula/chemistry , Plant Components, Aerial/chemistry , Plant Extracts/therapeutic use , Animals , Anti-Anxiety Agents/isolation & purification , Data Interpretation, Statistical , Disease Models, Animal , Female , Male , Maze Learning/drug effects , Mice , Motor Activity/drug effects , Plant Extracts/isolation & purificationABSTRACT
Experiments on outbred albino mice showed a significant anxiolytic effect of aqueous tincture of the aerial part of Myosotis arvensis (L.) (Boraginaceae) in a single daily dose of 0.5 ml/kg. In a dose of 2 ml/kg, the tincture of M. arvensis aerial part exhibited an anxiolytic and antidepressant effect. In contrast to phenazepam, aqueous tincture of M. arvensis did not inhibit exploratory and motor activities.
