ABSTRACT
A variant called APOE4 is notorious for its link to Alzheimer's. Can new insights into its function help stave off disease?
Subject(s)
Alzheimer Disease , Apolipoprotein E4 , Humans , Alzheimer Disease/genetics , Apolipoprotein E4/genetics , Male , Female , Aged , FamilyABSTRACT
Six years into agency's efforts to curtail foreign interference, some say it should apologize.
Subject(s)
National Institutes of Health (U.S.) , Research Personnel , United States , Asia , International Cooperation , Research Support as Topic , HumansABSTRACT
Republicans attack retired research institute head, while Democrats rally to his defense.
Subject(s)
COVID-19 , National Institute of Allergy and Infectious Diseases (U.S.) , Politics , Humans , United States , COVID-19/epidemiology , COVID-19/etiologyABSTRACT
Lawmakers propose reducing 27 institutes to 15.
Subject(s)
National Institutes of Health (U.S.) , National Institutes of Health (U.S.)/economics , United States , PoliticsABSTRACT
Drop in 21st Century Cures Act funding will slow BRAIN and All of Us projects.
Subject(s)
Genomic Medicine , National Institutes of Health (U.S.) , Neurosciences , Research Support as Topic , Humans , Financing, Government , National Institutes of Health (U.S.)/economics , United States , Neurosciences/economics , Genomic Medicine/economicsABSTRACT
EcoHealth Alliance mishandled grant that helped fund virus studies in China, officials say.
Subject(s)
Biomedical Research , COVID-19 , Pandemics , Research Support as Topic , Humans , Biomedical Research/economics , China , COVID-19/epidemiology , Pandemics/economics , United StatesABSTRACT
New policy governs gain-of-function and "dual-use" studies.
Subject(s)
Biomedical Research , Gain of Function Mutation , Viruses , Humans , Biomedical Research/standards , United States , Viruses/genetics , Viruses/pathogenicity , Guidelines as TopicABSTRACT
Belated Senate and House compromise eliminates policy riders restricting certain studies.
Subject(s)
Biomedical Research , Budgets , National Institutes of Health (U.S.) , National Institutes of Health (U.S.)/economics , Policy , United States , Gain of Function Mutation , Biomedical Research/economics , Biomedical Research/trendsABSTRACT
All of Us finds new DNA variants and refines genetic risk scores in diverse groups.
Subject(s)
Disease , Genome, Human , Human Genome Project , Humans , Genetic Risk Score , Genetic Variation , National Institutes of Health (U.S.) , Disease/genetics , RiskABSTRACT
Efforts to ban "gain-of-function" research on viruses and bacteria worry scientists.
Subject(s)
Biomedical Research , Gain of Function Mutation , Wisconsin , Biomedical Research/economics , Biomedical Research/legislation & jurisprudence , Bacteria/genetics , Bacteria/pathogenicity , Viruses/genetics , Viruses/pathogenicity , Fungi/genetics , Fungi/pathogenicityABSTRACT
Improving patient care is top priority for head of world's largest biomedical research funder.
Subject(s)
Biomedical Research , National Institutes of Health (U.S.) , Patient Care , Humans , Biomedical Research/economics , National Institutes of Health (U.S.)/economicsABSTRACT
Verve Therapeutics says its base-editing approach may help prevent heart disease in many people.
Subject(s)
CRISPR-Cas Systems , Cholesterol, LDL , Gene Editing , Genetic Therapy , Hyperaldosteronism , Proprotein Convertase 9 , Humans , Base Pairing/genetics , Cholesterol, LDL/blood , Cholesterol, LDL/genetics , DNA/genetics , Genetic Therapy/methods , Hyperaldosteronism/genetics , Hyperaldosteronism/prevention & control , Proprotein Convertase 9/blood , Proprotein Convertase 9/genetics , Clinical Trials as TopicABSTRACT
ARPA-H aims to be unlike NIH, director says.
Subject(s)
Academies and Institutes , Biomedical Research , Biomedical Research/economics , Biomedical Research/trends , United States , RiskABSTRACT
Probe clears Marc Tessier-Lavigne of misconduct but criticizes lab culture and lack of "appetite" for corrections.
ABSTRACT
Concerns include confidentiality, accuracy, and "originality of thought".
ABSTRACT
Some scientists worry reporting requirement is burdensome-and even insulting.
Subject(s)
Biomedical Research , Information Dissemination , International Cooperation , Policy , Humans , National Institutes of Health (U.S.) , United StatesABSTRACT
FDA is expected to endorse Duchenne muscular dystrophy treatment, as safety concerns linger over uses of viruses.
Subject(s)
Genetic Therapy , Muscular Dystrophy, Duchenne , Humans , Genetic Therapy/adverse effects , Genetic Therapy/methods , Genetic Therapy/mortality , Muscular Dystrophy, Duchenne/therapy , United States Food and Drug Administration , DependovirusABSTRACT
Experts split on whether risks of perpetuating racism mean group comparisons should not be done.
ABSTRACT
Small trial offers first clinical evidence that supports a personalized vaccine approach.