(Z)-Ethyl 2-cyano-3-(1H-imidazol-2-yl)acrylate.

The crystal structure of the title compound, C9H9N3O2, features N-H⋯N and C-H⋯O inter-actions. The N-H⋯N inter-action generates a chain running along the a axis and the C-H⋯O inter-action generates a chain along the c axis. An intra-molecular C-H⋯O inter-action is also observed.

(E)-Ethyl 2-cyano-3-(furan-2-yl)acrylate.

There are two independent mol-ecules in the asymmetric unit of the title compound, C(10)H(9)NO(3), in both of which, all non-H atoms except for the methyl C atom lie nearly in the same plane [maximum deviations = 0.094 (3) and 0.043 (2) Å]. In the crystal, each independent mol-ecules is linked by pairs of C-H⋯O inter-actions, generating inversion dimers with R(2) (2)(10) ring motifs.

1-(3,5-Dichloro-phen-yl)-1H-1,2,3,4-tetra-zole.

In the title compound, C(7)H(4)Cl(2)N(4), the dihedral angle between the tetra-zole and benzene rings is 17.2 (2)°. In the crystal, C-H⋯N inter-actions link the mol-ecules into a flattened helical chain along the b axis.

(E)-Ethyl 2-cyano-3-(1H-pyrrol-2-yl)acrylate.

All the non-H atoms of the title compound, C(10)H(10)N(2)O(2), are nearly in the same plane with a maximum deviation of 0.093 (1) Å. In the crystal, adjacent mol-ecules are linked by pairs of inter-molecular N-H⋯O hydrogen bonds, generating inversion dimers with R(2) (2)(14) ring motifs.

8-Formyl-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl-benzenesulfonate.

In the title compound, C(18)H(14)O(6)S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.032 (2) Å. The dihedral angle between the benzene ring and the coumarin ring system is 32.41 (8)°. The crystal packing is stabilized by inter-molecular C-H⋯O inter-actions, generating C(8), C(10) and C(11) chains and an R(2) (2)(10) ring. The formyl group is disordered over two sets of sites, with occupancies of 0.548 (5) and 0.452 (5).

8-[(Hydrazinyl-idene)meth-yl]-4-methyl-2-oxo-2H-chromen-7-yl 4-methyl-benzene-sulfonate.

In the title compound, C(18)H(16)N(2)O(5)S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.078 (1) Š(r.m.s. deviation = 0.046 Å). The dihedral angle between the coumarin ring system and the toluene ring (r.m.s. deviation = 0.004 Å) is 2.77 (1)°. The crystal packing is stabilized by C-H⋯O and N-H⋯O inter-molecular hydrogen bonds generating C(8), C(9) and C(11) chains and R(2) (2)(14), R(2) (2)(23) and R(4) (3)(13) ring graph sets.

Ethyl 4-(3-bromo-phen-yl)-6-methyl-2-oxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

In the title compound, C(14)H(15)BrN(2)O(3), the dihydro-pyrimidin-one ring adopts a boat conformation. In the crystal, adjacent mol-ecules are linked through N-H⋯O hydrogen bonds forming an R(2) (2)(8) ring motif and generating a zigzag chain extending in [010].

1-(2-Azido-acet-yl)-3-methyl-2,6-diphenyl-piperidin-4-one.

In the title compound, C(20)H(20)N(4)O(2), the piperidine ring adopts a distorted boat conformation. The two phenyl rings form dihedral angles of 82.87 (1) and 84.40 (1)° with respect to the piperidine ring. The crystal packing is stabilized by inter-molecular C-H⋯O and C-H⋯N inter-actions.

(Z)-2-[2-(4-Methyl-benzyl-idene)hydrazin-yl]pyridine.

Mol-ecules of the title compound, C(13)H(13)N(3), are essentially planar (r.m.s. deviation for all non-H atoms = 0.054 Å). The dihedral angle between the two aromatic rings is 6.33 (5)°. In the crystal, pairs of centrosymmetrically related mol-ecules are linked through N-H⋯N hydrogen bonds, forming N-H⋯N dimers with graph-set motif R(2) (2)(8).

Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins.

A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR, 19F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein.

N-(2-Chloro-quinolin-3-ylmethyl-ene)aniline.

The title compound, C(16)H(11)ClN(2), displays a trans configuration across the C=N bond and a transoid arrangement across the quinoline ring and the azomethine C atom. This arrangement facilitates C-H⋯Cl interactions. The packing in the crystal structure is due to inter-molecular C-H⋯π and Cl⋯π (3.52 and 3.84 Å) inter-actions. The dihedral angle between the least-squares planes of 2-chloro-quinoline and phenyl-amine is 16.61 (2)°.