[Neurospecific proteins and autoantibodies in serum of patients with acute ischemic stroke].

Neurospecific enolase (NSE), gliofibrillar acid protein (GFAP), S100 protein and autoantibodies (AAB) to these proteins have been measured in the blood of 42 patients with acute ischemic stroke. Concentrations of all parameters we re increased in patients compared to the control group. There were a positive correlations between contents of AAB to GFAP and AAB to NSE (r = 0.470; p < 0.015) and a reverse correlation between concentrations of NSE and AAT to NSE (r = -0.301; p < 0.028). A study of the relationship between intensity of neurological deficit and AAB concentrations revealed the reverse correlation between the level of AAB to GFAP and scores on the European Stroke scale (ESS) (r = -0.509; p < 0.009) at the first day of ischemic stroke, i.e. in patients with marked neurological deficit (low scores on ESS) the levels of AAB to GFAP were higher. The higher concentration of AAB to NSE was found for the satisfactory rehabilitation, while the neurological deficit was significantly more severe (p = 0.034) at the AAT to NSE level less than 1.19 relative units. The more complete rehabilitation to the 21st day was reverse-correlated to the NSE concentration (r = -0.309; p < 0.026). There was the positive correlation between the restoration of lost functions (the increase of ESS scores from the 1st to 21st days) and levels of AAB to GFAP (r = 0.505; p < 0.023) and AAB to S100 (r = 0.450; p < 0.046).

[The use of pantogam in patients with moderate cognitive disorders of vascular genesis].

Forty-five patients with discirculatory encephalopathy, I-II stages, and moderate cognitive disorders of vascular genesis were examined. All patients were stratified into 2 groups: 25 patients of the main group received pantoham in the complex therapy in dose 250 mg 3 times a day during 2 months; 20 patients of the comparison group received only a unified therapy (antihypertensive drugs and, if necessary, coronarolytics and glucose-decreasing drugs. The clinical/neurological and instrumental examinations and neuropsychological testing were performed before the treatment and after 8 weeks. The subjective improvement of the state of patients treated with pantoham, together with the significant improvement (p < 0.05) in the performance of cognitive tests (a battery of frontal dysfunction tests, the Clock drawing test, generalization ability) was found. No positive changes in the performance of cognitive tests were observed in the comparison group. None of the patients had side-effects that led to a change of the therapeutic scheme.

[The impact of microcirculation dysfunction on the clinical presentations of multiple sclerosis in patients above 45 years and the possible ways of correction of the vascular pathology].

The study was based on the hypothesis that the age-specific vascular disturbances, along with autoimmune processes, might play a role in the development of neurodegenerative changes in multiple sclerosis (MS) in patients above 45 years. Vascular disturbances were assessed using single photon emission computer tomography. Also magnetic resonance imaging, ultrasound dopplerography of the brain and evaluation of patient's neurological and mental state with the MMSE were used. The main group consisted of 10 patients with MS aged above 45 years with the history of vascular disturbances was studied before and after the treatment with fezam, a preparation contained piracetam and cinnarizine. It has been shown that in the presence of the vascular risk factors the neurological deficit can increase in this group of patients not only due to inflammation and demyelinization but to vascular disturbances as well. In these cases, the administration of fezam used in treatment of brain vascular disorders proved to be effective. The drug exerted a positive effect on the patient's mental state including cognitive dysfunction.

[Hemodynamic characteristics of the brain in angiogenic cochleovestibulopathies and lipid distress syndrome (Communication 2--radionuclide diagnosis)]. / Osobennosti gemodinamiki golovnogo mozga pri angiogennykh kokhlevestibulopatiiakh i lipidnom distress-sindrome (Soobshchenie 2--radionuklidnaia diagnostika).

Radionuclide tracing employed to study arterial and venous blood supply to the brain in 100 patients with angiogenic cochleovestibulopathies and lipid distress syndrome has provided information on perfusion of the brain, arterial and venous hemodynamics with reference to the form of cochleovestibular disorders and atherosclerotic defects of extra- and intracranial cerebral arteries.