Subject(s)
Gelsolin , IgA Vasculitis , Abdominal Pain/blood , Abdominal Pain/diagnosis , Abdominal Pain/etiology , Biomarkers/analysis , Child , Disease Progression , Female , Gelsolin/analysis , Gelsolin/blood , Humans , IgA Vasculitis/blood , IgA Vasculitis/complications , IgA Vasculitis/diagnosis , IgA Vasculitis/physiopathology , Joint Diseases/blood , Joint Diseases/diagnosis , Joint Diseases/etiology , Kidney Diseases/blood , Kidney Diseases/diagnosis , Kidney Diseases/etiology , Male , Patient Acuity , Prospective Studies , Protective Factors , TurkeyABSTRACT
We analyzed 25 pediatric renal transplantation patients on sirolimus (SRL) therapy to assess changes in serum creatinine, glomerular filtration rate, electrolytes, triglycerides, cholesterol, and side effects. Mean time to initiate SRL therapy was 3.2 years. The serum creatinine levels of patients on SRL treatment at 1, 6, 12, and 24 months were 1.67 ± 1.15 mg/dL, 1.18 ± 0.52 mg/dL, 1.24 ± 0.32 mg/dL, 1.15 ± 0.31 mg/dL, and 1.17 ± 0.12 mg/dL, respectively. We observed proteinuria in 3, hyperlipidemia in 5, and anemia in 2 patients, but none had the treatment discontinued. We diagnosed interstitial pneumonia in (n = 1), nasal acneiform lesions (n = 1), and lower extremity edema (n = 1). Hypokalemia developed in 1 subject with high blood SRL levels. In the follow-up period there was no case of acute rejection episode during SRL therapy.