ABSTRACT
Biocompatible gold nanoparticles (AuNPs) are used in wound healing due to their radical scavenging activity. They shorten wound healing time by, for example, improving re-epithelialization and promoting the formation of new connective tissue. Another approach that promotes wound healing through cell proliferation while inhibiting bacterial growth is an acidic microenvironment, which can be achieved with acid-forming buffers. Accordingly, a combination of these two approaches appears promising and is the focus of the present study. Here, 18 nm and 56 nm gold NP (Au) were prepared with Turkevich reduction synthesis using design-of-experiments methodology, and the influence of pH and ionic strength on their behaviour was investigated. The citrate buffer had a pronounced effect on the stability of AuNPs due to the more complex intermolecular interactions, which was also confirmed by the changes in optical properties. In contrast, AuNPs dispersed in lactate and phosphate buffer were stable at therapeutically relevant ionic strength, regardless of their size. Simulation of the local pH distribution near the particle surface also showed a steep pH gradient for particles smaller than 100 nm. This suggests that the healing potential is further enhanced by a more acidic environment at the particle surface, making this strategy a promising approach.
ABSTRACT
Free-space optical communication is a promising means to establish versatile, secure and high-bandwidth communication between mobile nodes for many critical applications. While the spatial modes of light offer a degree of freedom to increase the information capacity of an optical link, atmospheric turbulence can introduce severe distortion to the spatial modes and lead to data degradation. Here, we demonstrate experimentally a vector-beam-based, turbulence-resilient communication protocol, namely spatial polarization differential phase shift keying (SPDPSK), that can reliably transmit high-dimensional information through a turbulent channel without the need of any adaptive optics for beam compensation. In a proof-of-principle experiment with a controllable turbulence cell, we measure a channel capacity of 4.84 bits per pulse using 34 vector modes through a turbulent channel with a scintillation index of 1.09, and 4.02 bits per pulse using 18 vector modes through even stronger turbulence corresponding to a scintillation index of 1.54.
ABSTRACT
Viewers have often looked upon the BBC's science documentary strand, Horizon, as an authoritative source for scientific knowledge. Through interviews with the series' producers, this article examines the practices its producers perform to buttress their authority and generate the view that this show is itself a producer of knowledge, even while it is also televising and mediating science. Of particular note are references to science fiction to police boundaries between science and pseudoscience, and the use of original experimental trials to generate witnesses. These position Horizon as at least a node in the network of scientific knowledge production.
