ABSTRACT
We studied the effect of intravenous immune globulin (IVIG) infusion on the levels of hepatitis B and C antibodies in 10 premature babies. All four tested lots of a commercially purchased IVIG preparation were found to contain substantial amounts of hepatitis B core and hepatitis C antibodies. Our results show that passive transfer of hepatitis B and C virus antibodies occurred after IVIG infusion, and that the levels were dependent on the quantity of IVIG given. When assessing neonates for hepatitis, the factor of receipt of blood products, including IVIG, needs to be considered to interpret laboratory results.
Subject(s)
Hepacivirus/immunology , Hepatitis Antibodies/therapeutic use , Hepatitis B Antibodies/therapeutic use , Immunization, Passive , Immunoglobulins, Intravenous/therapeutic use , Infant, Premature/immunology , Gestational Age , Hepatitis Antibodies/administration & dosage , Hepatitis Antibodies/blood , Hepatitis B Antibodies/administration & dosage , Hepatitis B Antibodies/blood , Humans , Immunoglobulins, Intravenous/administration & dosage , Immunoglobulins, Intravenous/blood , Infant, Low Birth Weight/blood , Infant, Low Birth Weight/immunology , Infant, Newborn , Infant, Premature/bloodSubject(s)
Pemphigoid Gestationis/diagnosis , Autoimmune Diseases/diagnosis , Autoimmune Diseases/immunology , Autoimmune Diseases/pathology , Biopsy , Complement C3/analysis , Female , Humans , Immunoglobulins/analysis , Infant, Newborn , Male , Pemphigoid Gestationis/immunology , Pemphigoid Gestationis/pathology , Pregnancy , Skin/immunology , Skin/pathologyABSTRACT
Capillary blood samples obtained from a warmed distal phalanx of the right hand were compared with either temporal or right radial arterial blood samples for PO2, PCO2, and pH in 33 critically ill newborn infants. The blood pressure and skin temperatures of each infant and the ambient oxygen concentration were recorded at the time the blood was sampled. Sixty-eight paired PO2 analyses yielded a regression line close to the line of identity. The mean difference between digital capillary and arterial PO2 was 11.3 +/- 1.4 mm Hg (r = 0.92). The results were similar for the paired PCO2 analyses (r = 0.84) and for the paired pH analyses (r = 0.94). The correlation between arterial PO2 and digital capillary PO2 deteriorated when the systolic blood pressure of the patient was below 35 mm Hg. There was no correlation between skin temperature and capillary-arterial PO2 differences. The frequency of retrolental fibroplasia leading to blindness was not different from that in nurseries that sample umbilical arterial blood routinely.