ABSTRACT
Pleomorphic myxoid liposarcoma (PML) is a newly recognized entity with aggressive clinical behavior and a tendency to recur. It has histological features of both myxoid and pleomorphic liposarcoma and lacks the molecular and structural chromosomal abnormalities associated with myxoid and pleomorphic liposarcoma. The data about their response to chemotherapy is quite sparse. We report a case of incidentally detected pleomorphic myxoid liposarcoma of the mediastinum in a 32-year-old gentleman. After resection and adjuvant chemotherapy with doxorubicin and ifosfamide, there was no evidence of residual disease at the end of treatment. During a routine follow-up 5 months later, he was found to have a recurrence of the disease with histological confirmation. He received a trabectedin given its activity in myxoid liposarcoma. However, he had toxicities and progression leading to its discontinuation. Subsequently, eribulin was started as the next line of therapy. After 4 cycles of chemotherapy, response assessment was suggestive of partial response, which is still maintained after 7 cycles of eribulin. This is the first report of this entity responding to a newer chemotherapy regimen.
ABSTRACT
Aim: Clinicopatholgical findings and outcomes in epithelioid sarcoma (ES) patients. Materials & methods: ES patients registered in sarcoma clinic from 2015 to 2021. Results: There were 20 patients with median age of 26 years. Majority had distal ES (70%) and advanced disease (85%). In patients with advanced disease lymph nodes were involved in 65%, lungs in 58% and others in 35%. Among 14 patients who underwent biopsy outside our institute, nine (64.2 %) had been initially misdiagnosed. Response rates to doxorubicin (n = 12), pazopanib (n = 6), gemcitabine/docetaxel (n = 5), tazemetostat (n = 3) and immunotherapy (n = 2) used in various lines were 16, 16, 20, 33 and 0%, respectively. Conclusion: Our patients had an advanced-stage and distal ES, with a modest response to chemotherapy.
Epithelioid sarcoma is an uncommon subtype of soft tissue sarcoma with a variable clinical course. We analyzed the outcomes of 20 patients registered under our Sarcoma Medical Oncology clinic from 2015 to 2021. The majority of our patients had an advanced stage at presentation with lymph nodal and lung metastasis. Due to rarity and overlapping histological findings many patients may be initially misdiagnosed. Patients with advanced stages are treated with various chemotherapeutic agents, which have very low response rates. Tazemetostat has shown some promise with responses in up to a third of patients.
ABSTRACT
BACKGROUND: Gingival recession defects (GRD) are one of the most commonly encountered conditions for which periodontal treatment is required. Several attempts have been made to classify GRD. Among all the classifications Millers classification for gingival recessions is the most accepted. Recently, several limitations and drawbacks have been pointed out in Miller's classification system. The aim of the present study is to test the reliability of the recently proposed Mahajan's Modification of the Miller's Classification for GRD. MATERIALS AND METHODS: All 15 males and 11 females between the ages of 22 and 55 years (mean age, 37.15 year) with at least one buccal gingival recession were consecutively recruited by the same periodontist in order to test the reliability of the new classification of GRD. The classification was tested by two examiners blinded to the data collected by the other examiner. Intra-rater and inter-rater agreement was assessed. RESULTS: The new classification system of gingival recessions was tested in a total of 175 gingival recessions in 26 patients. The intraclass correlation coefficient for inter-rater agreement was 0.90, showing an almost perfect agreement between the examiners. CONCLUSION: The newly proposed classification system eliminates the drawbacks and limitations associated with Miller's classification system and can be used to classify GRD reliably.
ABSTRACT
More than 500 bacterial strains may be found in dental plaque. In the beginning, the emphasis was laid on the isolation of bacteria in pure culture to define their properties. However, now, it has been well established that in nature the bacteria exist as a member of polymicrobial community or consortium of interacting species. Interactions among human oral bacteria are integral to the development and maturation of the plaque. These interactions occur at several levels including physical contact, metabolic exchange, small-signal molecule-mediated communication, and exchange of genetic material. This high level of interspecies interaction benefits the microorganism by providing a broader habitat range, effective metabolism, increasing the resistance to host defence, and enhancing their virulence. This generally has a detrimental effect on the host and is attributed to many chronic infections which poses a therapeutic challenge.
