ABSTRACT
Invited for the cover of this issue are Tatiyana Serebryanskaya, Mikhail Kinzhalov and co-workers at St. Petersburg State University, the Research Institute for Physical Chemical Problems, Belarusian State University, Togliatti State University and Blokhin National Medical Research Center of Oncology. The image depicts the shield of Pallas Athena with the structure of a palladium carbene complex that protects against triple-negative breast cancer. Read the full text of the article at 10.1002/chem.202400101.
Subject(s)
Antineoplastic Agents , Cell Proliferation , Coordination Complexes , Triple Negative Breast Neoplasms , Triple Negative Breast Neoplasms/drug therapy , Triple Negative Breast Neoplasms/pathology , Humans , Coordination Complexes/chemistry , Coordination Complexes/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cell Proliferation/drug effects , Female , Cell Line, Tumor , Palladium/chemistry , Methane/analogs & derivatives , Methane/chemistry , Methane/pharmacologyABSTRACT
Hydrolytically stable PdII and PtII complexes supported by acyclic diaminocarbene ligands represent a novel class of structural organometallic anticancer agents exhibiting nanomolar antiproliferative activity in a panel of cancer cell lines (IC50 0.07-0.81â µM) and up to 300-fold selectivity for cancer cells over normal primary fibroblasts. The lead drug candidate was 300 times more potent than cisplatin inâ vitro and showed higher efficacy in reducing the growth of aggressive MDA-MB-231 xenograft tumors in mice.
Subject(s)
Antineoplastic Agents , Cell Proliferation , Coordination Complexes , Triple Negative Breast Neoplasms , Humans , Animals , Mice , Triple Negative Breast Neoplasms/drug therapy , Triple Negative Breast Neoplasms/pathology , Antineoplastic Agents/pharmacology , Antineoplastic Agents/chemistry , Cell Line, Tumor , Cell Proliferation/drug effects , Coordination Complexes/chemistry , Coordination Complexes/pharmacology , Coordination Complexes/chemical synthesis , Female , Xenograft Model Antitumor Assays , Drug Screening Assays, Antitumor , Cisplatin/pharmacology , Palladium/chemistry , LigandsABSTRACT
A series of platinum complexes featuring phosphine and isocyanide ligands [PtX2(PPh3)(CNCy)] (X = Cl, Br, and I) as well as their parent phosphine [PtX2(PPh3)2] and isocyanide [PtX2(CNCy)2] analogues have been prepared and evaluated as catalysts for the photocatalytic hydrosilylation of alkynes. Under violet light irradiation (λmax = 400 nm), phosphine-isocyanides complexes [PtX2(PPh3)(CNCy)] gave high yields of silylated products (product yield up to 99%, TONs up to 1.98 × 103). The blue light irradiation (λmax = 450 nm) was more suitable for the parent phosphine complexes [PtX2(PPh3)2], which showed comparable efficiency (product yield up to 99%, TON up to 1.98 × 103), while isocyanide complexes [PtX2(CNCy)2] were not active.
ABSTRACT
A novel series of cyclometalated platinum(II) complexes bearing acyclic diaminocarbene (ADC) ancillary ligands were designed and prepared. Their photophysical properties were systematically studied through experimental and theoretical investigations. All complexes exhibit green phosphorescence with a quantum efficiency of up to 45% in 2 wt% doped PMMA film at room temperature. The complexes are used as light-emitting dopants for organic light-emitting diode (OLED) fabrication. The devices displayed a green emission with a maximum current efficiency of 2.9 cd A-1 and a luminance of 2700 cd m-2. These results show that these cyclometalated platinum(II) complexes can be used as efficient green emitting components of OLED devices.