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J Antibiot (Tokyo) ; 75(4): 199-206, 2022 04.
Article in English | MEDLINE | ID: mdl-35241792

ABSTRACT

Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.


Subject(s)
Antimalarials , Hypocreales , Anti-Bacterial Agents , Antimalarials/pharmacology , Hypocreales/chemistry , Macrolides/chemistry , Macrolides/pharmacology , Magnetic Resonance Spectroscopy
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