Subject(s)
Botulinum Toxins, Type A/therapeutic use , Neurotransmitter Agents/therapeutic use , Psoriasis/drug therapy , Adult , Calcitonin Gene-Related Peptide/analysis , Drug Resistance , Female , Humans , Male , Middle Aged , Nerve Fibers/pathology , Pilot Projects , Psoriasis/pathology , Severity of Illness Index , Skin/innervation , Skin/pathology , Substance P/analysisABSTRACT
Graft-versus-host disease (GVHD) is the major complication of hematopoietic stem cell transplantation and is associated with high mortality in severe cases. The skin is one of the major organs affected in both acute and chronic GVHD. This review aims to elucidate the basic characteristics of GVHD, and the role and contribution of dermatologists in the care of patients with this condition.
Subject(s)
Dermatology , Graft vs Host Disease/diagnosis , Graft vs Host Disease/therapy , Physician's Role , Skin Diseases/diagnosis , Skin Diseases/therapy , Acute Disease , Calcineurin Inhibitors/therapeutic use , Chronic Disease , Graft vs Host Disease/etiology , Hematopoietic Stem Cell Transplantation/adverse effects , Humans , Immunoglobulins, Intravenous/therapeutic use , PUVA Therapy , Photopheresis , Risk Factors , Skin Diseases/etiology , Steroids/therapeutic useABSTRACT
The effect of intermolecular interactions on the conformational variety of flexible mono-dentate ligands in coordination compounds has been investigated through the preparation of two series of mercury(ii) complexes. In this regard, the molecular and structural architecture of eight complexes, [HgCl2(L(amide-Cl))2] (), [HgCl2(L(amide-Br))2] (), [HgBr2(L(amide-Br))2] (), and [HgI2(L(amide-Br))2] (), as the first series and [HgBr2(L(imine-Cl))2] (), [HgBr2(L(imine-Br))2] (), [HgI2(L(imine-Cl))]n (), and [HgI2(L(imine-Br))]n (), as the second series, using two kind of flexible ligands, N-(1-halonaphthalen-4-yl)nicotinamide, L(amide-X), and 4-halo-N-((pyridin-3-yl)methylene)naphthalen-1-amine, L(imine-X), has been studied. Inspection of the packing of these compounds clearly shows the presence of conformational changes in the arrangement of the ligands in each series. Although there are slight differences between the crystal packing of these compounds, it seems that π-involving intermolecular interactions including πnaphπnaph in the first series and πimineπpy/naph in the second series with the cooperation of Hgπpy can lock the ligand conformational variety to a single conformer.
ABSTRACT
OBJECTIVES: To elucidate whether granuloma faciale (GF) and erythema elevatum diutinum (EED), two inflammatory skin dermatoses, meet the consensus histopathologic diagnostic criteria for immunoglobulin G4-related disease (IgG4-RD). METHODS: With institutional review board approval, we assessed the clinical, microscopic, and immunophenotypic features of skin specimens of patients with GF and EED. We compared these findings with previously published consensus diagnostic criteria for IgG4-RD. RESULTS: Thirty-two patients (GF, n = 25; EED, n = 7) met study inclusion criteria. Histopathologic findings of small-vessel vasculitis, dermal fibrosis, and plasma cell infiltrates were uniformly present, and eosinophilic inflammation was frequent. No specimen met diagnostic criteria for IgG4-RD. CONCLUSIONS: Our results indicate that despite some histopathologic similarities between GF/EED and IgG4-RD, the cases did not meet the consensus immunohistochemical diagnostic criteria for IgG4-RD.
Subject(s)
Facial Dermatoses/diagnosis , Granuloma/diagnosis , Immunoglobulin G/immunology , Skin Diseases/diagnosis , Skin/pathology , Vasculitis, Leukocytoclastic, Cutaneous/diagnosis , Adult , Aged , Aged, 80 and over , Biopsy , Facial Dermatoses/immunology , Facial Dermatoses/pathology , Female , Fibrosis , Granuloma/immunology , Granuloma/pathology , Humans , Immunohistochemistry , Inflammation/pathology , Male , Middle Aged , Plasma Cells , Skin Diseases/immunology , Skin Diseases/pathology , Vasculitis, Leukocytoclastic, Cutaneous/immunology , Vasculitis, Leukocytoclastic, Cutaneous/pathologySubject(s)
Glutathione Peroxidase/blood , Selenium/blood , Vitiligo/blood , Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Vitiligo/enzymologyABSTRACT
This report describes a case of leiomyoma of the ankle occurring at an unusual age. A 5-month-old girl presented with an asymptomatic nodule on her left ankle.
Subject(s)
Ankle , Leiomyoma/pathology , Skin Neoplasms/pathology , Biopsy , Diagnosis, Differential , Female , Humans , Infant , Leiomyoma/surgery , Skin Neoplasms/surgeryABSTRACT
Squamoid eccrine ductal carcinoma is a rare primary cutaneous tumor exhibiting both squamous and adnexal ductal differentiation. The cell of origin of these tumors is unknown, and they have been classified both as variants of cutaneous squamous cell carcinoma and as a type of eccrine carcinoma. Only 6 of these tumors have been reported in the literature to date. We report an additional case of a slow-growing tumor, occurring on the great toe of a 61-year-old woman, which was unusual as it showed follicular differentiation in addition to squamoid and ductal areas. The lesional cells were positive for cytokeratins 7 and 17, carcinoembryonic antigen (which highlighted the ductal structures), and p63 (favoring a primary cutaneous tumor) and showed low levels of staining with Ki-67 and p53, consistent with a low-grade tumor. We postulate that these tumors may be closely related to microcystic adnexal carcinoma and similarly show differentiation along both follicular and ductal lines, likely indicating folliculosebaceous-apocrine, rather than eccrine, origin or differentiation.
Subject(s)
Carcinoma, Skin Appendage/pathology , Carcinoma, Squamous Cell/pathology , Eccrine Glands/pathology , Hair Follicle/pathology , Skin Neoplasms/pathology , Carcinoma, Skin Appendage/metabolism , Carcinoma, Squamous Cell/metabolism , Cell Differentiation , Eccrine Glands/metabolism , Female , Humans , Immunohistochemistry , Middle Aged , Skin Neoplasms/metabolism , Toes/pathologyABSTRACT
Lipoid proteinosis is a very rare genodermatosis characterized by infiltration of hyaline material into the skin, oral cavity, larynx and internal organs. It usually presents in infancy with hoarseness. Although about 300 cases have been reported in the literature, the occurrence of the disease is rare in siblings. In this report we introduce three siblings with this disease.
