ABSTRACT
The preparation of a number of amines related to haematoporphyrin (HP) and haematoporphyrin derivative (HPD) have been studied and their composition and structure discussed through examination of their 1H, 13C NMR and mass spectral data and other physical properties. In vitro biological studies have been carried out and have shown these amines to have a similar photodynamic efficiency to that of HPD. One of these showed cytotoxic properties at exceptionally low light energy levels.
Subject(s)
Hematoporphyrin Derivative/chemistry , Hematoporphyrin Photoradiation , Neoplasms/drug therapy , Cell Survival/drug effects , Hematoporphyrins/chemistry , Humans , Molecular Structure , Neoplasms/pathology , Nitrogen/chemistry , Structure-Activity Relationship , Tumor Cells, CulturedABSTRACT
It has been suggested recently that neither an ester nor an ether linkage was present in the tumour-localising component of Photofrin II (PFII) (a commercial preparation of DHE). We now report that our chemical and spectroscopic studies, establish the presence of an ester linkage with the possibility that an ether linkage may also be involved.
