[A clinico-laboratory validation of the combined therapy of lichen ruber planus of the oral mucosa]. / Kliniko-laboratornoe obosnovanie kompleksnoi terapii krasnogo ploskogo lishaia slizistoi obolochki polosti rta.

Fifty-two patients with lichen planus were examined over the course of disease using clinical, microbiological, and histological methods. Treatment protocols aimed at normalization of microbiocenosis have been developed, based on the detected microbiological and histological changes.

[Microbiocenosis study in chronic diseases of the oral mucosa]. / Izuchenie mikrobiotsenoza pri khronicheskikh zabolevaniiakh slizistoi obolochki polosti rta.

Examinations of 18 patients with recurrent aphthous stomatitis, 8 with ulcerative necrotic gingivitis, 10 with lichen planus, 10 with herpetic stomatitis, and of 24 patients without evident clinical symptoms of buccal mucosa involvement but complaining of various stomatogenic sensations, e.g. burning, tightness, pain and pricking in the buccal mucosa, perverted taste, etc., showed that chronic diseases of the buccal mucosa involve expressed shifts in the microbiocenosis, namely, dysbacteriosis of different severity.

[The local immunity of the oral cavity in dental caries]. / Sostoianie mestnogo immuniteta polosti rta pri kariese zubov.

Functional activity of local immunity with regard to dental caries in children is liable to appreciable individual fluctuations which depend on sex, age, and season. In children aged 4 to 5 no association between the titer of antibodies to cariogenic Streptococcus and number of carious lesions was observed, whereas in those aged 9 to 19 these parameters were in inverse relationship. In children aged 11-12 and 14-16 this association is inverse. Regression analysis of nonspecific and specific characteristics of local immunity of the oral cavity in children aged under 12 suffering from caries revealed functional insufficiency of the mechanisms regulating the local immunity, which disappears after fluoroprophylaxis. Test system for screening of mutant Streptococcus cannot be recommended for wide use to detect subjects sensitive to caries, because it has certain limitations as regards the age of examinees.

[Certification of oral hygiene agents from a microbiological viewpoint]. / Sertifikatsiia sredtsv gigieny polosti rta s mikrobiologicheskikh pozitsii.

The authors validate the necessity of hygienic certification including microbiological control of perfumes and cosmetics, to which oral hygiene means belong. They consider that the absence of sanitary regulations for some goods, toothpastes included, is one of the causes, responsible for the absence of a proper sanitary control on the part of State Epidemiological Survey of the Russian Federation. In accordance with the resolution "On Certification of Perfumes and Cosmetics" issued in 1994, Central Research Institute of Stomatology is appointed the central institution responsible for certification of means of oral hygiene, and at present its main task is development of sanitary regulations, standards, methods of investigation, and training of personnel for institutions which are to carry out certification.

[The microbial flora and humoral protective factors in odontogenic inflammations in the maxillofacial area]. / Mikrobnaia flora i gumoral'nye faktory zashchity pri odontogennykh vospaleniiakh v cheliustno-litsevoi oblasti.

Some features in the pathogenesis of various forms of an inflammatory process were demonstrated by immunologic and microbiologic methods in patients with odontogenic infections. A close relationship has been revealed between microflora of an inflammatory focus, immune response type, and inflammation course in the maxillofacial area.

[The morphology of the microorganisms from the contents of a periodontal pocket in relation to the severity of the periodontitis]. / Morfologiia mikroorganizmov soderzhimogo zubodesnevogo karmana v zavisimosti ot tiazhesti parodontita.

Ninety-five patients with periodontitis of slight and medium severity were examined, 21 of them without concomitant diseases, 44 with essential hypertension, and 30 with diabetes mellitus. Besides clinical signs of periodontal abnormalities, the examinations revealed using phase-contrast microscopy four groups of microorganisms in the periodontal pouch contents: cocci, immovable and movable bacilli, and tortuous forms. Multidimensional analysis of clinico-laboratory data revealed a relationship between the counts of some microorganisms and severity of periodontal pathology.

[The microbial status of the periodontal pocket]. / Mikrobnyi status parodontal'nogo karmana.

Analysis of components helped reveal the true relationships between the counts of individual representatives of the bacterial association in the contents of 18 periodontal pouches. Though the authors did their best to select a group of patients with the periodontitis course as similar as possible, the multidimensional grouping method has demonstrated the heterogeneity of this group. Four types of periodontal pouches were distinguished, differing by their bacterial status; this probably requires a differentiated approach to its correction.

[The nonspecific resistance of the oral cavity in adolescents]. / Sostoianie nespetsificheskoi rezistentnosti polosti rta u podrostkov.

Nonspecific resistance of the oral cavity was studied in 83 adolescents with catarrhal gingivitis, generalized or focal periodontitis, and intact periodontium. Mixed salivary and gingival fluid pools were examined. Immunoglobulins A and G, secretory immunoglobulin A, salivary and gingival fluid lysozyme, B lyse activity, and salivary excretion rate were measured. The findings evidence activation of local defense factors in catarrhal gingivitis at the expense of nonspecific defense factors, and a reduction of nonspecific defense parallelled by activation of the specific factors (secretory IgA) in periodontitis, which fact may be explained by augmentation of the antigenic stimulus at the expense of bacterial plaque dissemination under the gingiva.

[T-activin in the treatment of patients with recurrent aphthous stomatitis]. / T-aktivin v lechenii bol'nykh retsidiviruiushchim aftoznym stomatitom.

The authors sum up the experience gained in tactivin therapy of patients with recurrent aphthous stomatitis and analyze the effects of this drug on the patients' cellular and humoral immunity. Thirty patients with various forms of the condition were subcutaneously injected tactivin in a dose of 40 micrograms for 10 days. Biochemical parameters were virtually unchanged after therapy, whereas the immunity parameters evidenced essential shifts in humoral and cellular immunity. Clinical and laboratory data indicate a sufficiently high immunocorrective effect of tactivin in therapy of patients with recurrent aphthous stomatitis.

[An assessment of the variations in periodontal pathology in adolescents]. / Otsenka variatsii patologii parodonta u podrostkov.

Forty-seven adolescents with periodontal abnormalities were examined using clinical, immunologic, and functional tests (altogether 12 signs). Factor analysis helped cut down the number of signs just to 4 major factors. Interpretation of these factors and consideration of the individuals in factor space permitted singling out at least 2 types of periodontitis course, requiring, possibly, different approaches to therapy.

[A small-scale ultrasonic device for pre-sterilization treatment of dental instruments]. / Malogabaritnye ul'trazvukovye ustanovki dlia predsterilizatsionnoi obrabotki stomatologicheskikh instrumentov.

A mechanical method of treating stomatological instruments before sterilization is discussed. With this purpose in view, use is made of the ultrasonic outfits Y3M 001 and Y3M 002. Advantages of the suggested method of treating instruments are described.

[Kemantan treatment of patients with recurrent aphthous stomatitis]. / Lechenie kemantanom bol'nykh retsidiviruiushchim aftoznym stomatitom.

The authors assess the therapeutic efficacy of kemantan, an immunomodulator, used in the treatment of 30 patients with severe stubborn recurrent aphthous stomatitis (RAS). The blood immunological and biochemical characteristics were checked up over the course of treatment. Clinical and laboratory studies have shown that this immunocorrective agent is sufficiently effective for fibrous and cicatrizing RAS running a permanent course: the periods of the pathologic elements epithelialization are shortened, the permanent course of the condition is interrupted and the remissions are prolonged; clinical cure has been achieved in a number of cases. Kemantan is indicated for RAS patients only in cases with immunologic insufficiency, with immunologic responses monitored over the course of the treatment.