Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential.

BACKGROUND: The aim of this study was to evaluate the moisturizing efficacy of quince fruit, used in folk medicine. For this purpose, the phytoconstituents of Cydonia oblonga fruit extract, like phenolics and flavonoids, were determined. A stable cosmetic emulgel containing 4% Cydonia oblonga fresh fruit extract was formulated and subjected to in vivo evaluation compared with a control. MATERIALS AND METHODS: Cydonia oblonga fresh fruit extract was evaluated for tyrosinase activity and phenolic and flavonoid content. A stable emulgel containing 4% Cydonia oblonga fresh fruit extract was formulated and tested in a skin irritation test. After this, in vivo tests of erythema, moisture, sebum, and skin elasticity were conducted. The in vivo evaluation was a randomized and single-blind study. Thirteen healthy female volunteers were selected for a three-month study period. RESULTS: Cydonia oblonga fruit extract showed good phenolic and flavonoid content, which was associated with its good antioxidant and tyrosinase-inhibiting activity. Cydonia oblonga containing the emulgel showed a reduction in sebum and erythema, while the elasticity and moisture content showed increments in their levels after the three-month application of the formulation. The fruit contains chlorogenic acid and many sugars, which might account for its anti-inflammatory and sebum reduction effects; it is also capable of enhancing the skin's hydration level and decreasing skin sagging by enhancing its elasticity. CONCLUSION: The emulgel loaded with Cydonia oblonga fresh fruit extract is verified regarding its folklore status as a moisturizing agent that enhances the facial skin cells' resilience potential.

Evaluation of Pyrus communis and Cydonia oblonga fruit extract loaded emulgel on skin pliancy by using Cutometer.

Current study was designed to determine the skin elasticity potential of tested emulgel formulations. One emulgel containing Pyrus communis fruit extract and the other had Cydonia oblonga fruit extract. For this purpose 26 female subjects were selected and divided into two batches. Each batch has 13 volunteers, who used tested formulations and their base for 90 days. Skin elasticity were observed by using Cutometer MPA 580. From Cutometer skin mechanical parameters were calculated. From the results it was noted that emulgel formulations containing extracts of Pyrus Communis and Cydonia oblonga showed marked effect on the facial skin mechanical properties during 90 days study period. Statistically observed skin mechanical parameters of tested formulations had significant difference from base. After distention from Cutometer both formulations enhance the retraction ability of the skin as compared to base. Moreover it was also noted that Cydonia oblonga had more pronounced results than Pyrus communis loaded emulgel. From the results it has been interpreted that although both formulations has good potential to hydrate the skin resulting in intensification of its elasticity. As both fruits are rich source of phytonutrients like Vitamin C, Sugar, organic acids which might be the reason of their enhancement potential of skin pliancy.

Investigation of antiaging and skin rejuvenation potential of phyto-constituents from Pyrus communis loaded topical emulgel.

Pyrus communis fruit is traditionally used for improving the skin color and texture. The current study was designed to investigate Pyrus communis fruit phytoconstituents and their in-vivo rejuvenation effects on human skin by developing a stable emulgel formulation. Hydro-alcoholic extract of Pyrus communis was subjected to phytochemical analysis (TPC, TFC, antioxidant activity and anti-tyrosinase activity). A stable emulgel formulation loaded with 5% (w/w) Pyrus communis fruit extract was developed. Afterwards, this stable emulgel formulation was tested for effects on skin parameters and compared these with placebo (without fruit extract) by employing them on healthy human volunteers (n=13) for 3 months. Investigated in-vivo skin parameters were skin erythema, melanin, moisture, sebum and elasticity. Pyrus communis fruit extract showed excellent antioxidant and anti-tyrosinase activities. The developed formulation was stable in varying conditions of temperature and humidity for a period of 12 weeks. The active formulation showed statistically significant (p<0.05) decrease in skin melanin, erythema and sebum level while increase in skin elasticity and moisture content when compared with placebo. From findings it is concluded that Pyrus communis fruit extract loaded emulgel possesses antiaging potential with improvement in skin tone and elasticity, ameliorated skin moisture and showed skin whitening potential.

Formulation and clinical evaluation of topical dosage forms of Indian Penny Wort, walnut and turmeric in eczema.

Eczema is characterized by itching, lichenification, scaling, oedema and erythema. Current management strategies include corticosteroids, which are limited due to side effects. Many herbal remedies are used traditionally but unfortunately have not been validated in controlled clinical trials. Three popular traditional treatments of eczema include Indian pennywort, Walnut and Turmeric. In this study three topical formulations (micro emulsion, gel and ointment) were prepared from extracts of Indian pennywort, Walnut and Turmeric. These formulations were monitored for stability for a period of three months. Controlled clinical trials were conducted on 360 eczema patients. Clinical parameters observed were degree of erythema, oedema, scaling, itching and lichenification. Effects of each formulation on these clinical parameters were compared with placebo formulations. Micro emulsion formulations in all cases proved to be more effective in reducing semi quantitative scores of erythema and oedema. Itching was relieved more by gel formulation. The ointment showed more efficacy towards scaling and lichenification. Comparison of the effects of placebo and the specific formulations was performed by chi-square statistics and found to be highly significant. In summary it is concluded that all the formulations could be used as promising source for treatment of eczema.