[Alginates in the treatment of postgastroresection reflux esophagitis].

AIM: To evaluate the efficacy of alginates in the treatment of postgastroresection reflux esophagitis. SUBJECTS AND METHODS: Thirty-four post-Billroth II distal gastrectomy patients with reflux esophagitis and without erosive and ulcerative lesions of the gastric stump and anastomosis, who had received geviscon monotherapy for 6 weeks, were examined. Their symptoms and the data of esophagogastroduodenoscopy and impedance pH monitoring were assessed to control treatment results. RESULTS: There was statistically significant relief of the subjective (heartburn and bitter taste in the mouth) and objective symptoms of the disease and the reflux esophagitis in geviscon-treated patients. CONCLUSION: Geviscon is the drug of choice for treating reflux esophagitis in patients after partial distal gastrectomy provided that the acid-forming function of the gastric mucosa is minimally preserved.

[Antiproliferative activity of diclofenac at tumor cell cultures].

It is known that for risk group's importance of early diagnostics and prevention of a cancer of a thick section of the intestines. The view was expressed that the use of nonsteroidal anti-inflammatory drugs prospectively. The article presents the data obtained after the determination of the effect on the domestic drug diclofenac on the ability of the lines of tumor cells of the human colon multiply this antiproliferativoe action on the dose of the drug. Used photometric method for determination antiproliferativoe action. In vitro determined the effect of the national drug diclofenac on the ability of the lines of tumor cells of the human colon multiply, and is set in a dose-dependent effect. It is established that under the action of NSAIDS metabolic activity of cells can both strengthen and weaken that depends on the line of tumor cells and the concentration of the drug.

[Dysmotility of the esophagus in patients after stomach resection].

The aim of the work was to evaluate the esophageal motility in patients after distal gastrectomy of different sizes. It was found that in patients after gastrectomy with erosive and ulcerative lesions of the esophagus innofective esophageal motility often registered and this correlates with the reduction clearance indicator of the esophagus according to the pH-impedance monitoring.

[Panum (pantoprazole) effectiveness in the treatment of patients with GERD].

There are demonstrated results of a prospective comparative study on clinical efficacy and tolerability of Panum (INN: pantoprazole) under the sponsorship of"Unique Pharmaceutical Laboratories (India)". Were evaluated the results of a 28-day course of treatment of 30 patients with GERD, including those with severe reflux esophagitis (erosive and ulcerative), who received 40 mg of pantoprazole as monotherapy. Was found an algorithm with an intermediate control efficacy to individualizing the approach to therapy. As a result 16,7% of patients with severe reflux esophagitis required increasing the dose of pantoprazole to 80 mg/day in two divided doses, and the rest (83,3%) patients to achieve clinical and endoscopic remission of GERD was sufficient single dose of 40 mg of the drug. The results of this study indicated the efficacy and safety of the Panum drug in the treatment of GERD, including its complicated forms.

[Modern approach to the prevention and treatment of NSAID-gastropathy].

The article presents the results of the first Russian open randomized comparative multicenter study on the effectiveness of Famotidine in the prevention of NSAID-gastropathy--Barrier. In addition, were showen the results of studies of the drugs effect used for prevention of NSAID gastropathy (Famotidine, Lansoprazole, Misoprostol) for the synthesis of prostaglandins in the gastric mucosa in patients with osteoarthritis. Was shown the impact of alternative anti-inflammatory drug on the basis of an extract of ginger as joint pain, and the mucous upper gastrointestinal tract in patients with osteoarthritis.

[Oncogenesis humoral mechanisms regulation and NSAIDs ability in prevention of tumors].

The article observes modern data in mechanisms and pathways of carcinogenesis and tumor progression and the role of oncogenes, cytokines, growth factors in this process. The protective effects of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) for colorectal cancers in experimental and clinical studies are also demonstrated in this review.

[Efficiency of famotidin in prophylaxis of NSAIDs-induced gastropathy: result of multicenter research ZASLON-1 (protection of gastric mucosa from non-steroidal anti-inflammatory drugs].

This article presents results of the first Russian randomized study of NSAID-gastropaty prevention at patients receiving NSAIDS. Results of clinical and endoscopic monitoring of two groups of patients: 1st - 108 patients with AA or RA treated with diclofenac and famotidin and 2nd--116 patients with AA or RA receiving diclofenac treatment only. It was shown that combined use of diclofenac and famotidin reduces to 2.6 times frequency and significantly reduces severity of painful dyspepsia symptoms and antipain manifestations reduces more than twice frequency of erosive-ulcerous lesions of gastric mucosa and duodenum.

[Mechanism of photochemical oxidation of bacterioviridin]. / Issledovanie mekhanizma fotokhimicheskogo okisleniia bakterioviridina

The mechanism of bacterioviridin photochemical oxidation has been studied by the methods of ESR, flash-photolysis and low-temperature spectrophotometry. ESR spectrum of pigment cation-radical, a singlet line with H=11 G, g = 2.0027, has been recorded. The bands with maxima at 370, 470, 525, 590, 840 nm correspond to bacterioviridin cation -- radical in the absorption spectra. When -- benzoquinone is used as an electron acceptor with excitation light 640 nm the product of bacterioviridin irreversible oxidation is formed with the absorption band maximum 760 nm and absorption between 350 and 370 nm. It is suggested that this product is of double-oxidized non-radical nature and the mechanism of its formation through oxidation of the pigment cation-radical is discussed. The regeneration reaction of double-oxidized bacterioviridin up to cation-radical form in the presence of triphenylamine as a reducing agent has been carried out. The rate constants of cation-radical decay in the dark and desactivation of triplet state have the following values: K1=(1,64+/-0,15)-10(3) sec-1, K2=(13+/-2,0)-10(3) sec-1 correspondingly. The activation energy of the radical decay in the dark is Eact =(13,2-0,5) kcal/mole.

[EPR study of the mechanism of photooxidation of chlorophyll a by nitro compounds]. / Issledovanie metodom EPR mekhanizma fotookisleniia khlorofilla a nitrosoedineniiami

An ESR signal with g-value of 2,0026 and peak-to-peak with 8,5 Oe was observed in ethanole solutions of chlorophill a and nitroderivatives of naphtalene under red light illumination. The ESR signal consisted of chlorophyll cation radical resonance, superimposed on an nitronaphtalene anion radical. Less than the ratio greater than between the quantities of these radicals and the character of decay kinetics are influenced by the medium acidity. An analysis of kinetic curves is performed, and the effect of the medium acidity on the mechanism of one-electron transfer reaction between chlorophyll and nitronaphtalene molecules is explained.

[Photochemical generation of the cation-radical of bacteriochlorophyll b and the anion-radical of bacteriochlorophyll b and bacteriopheophytin b, components of the photosynthesizing bacteria Rhodopseudomonas viridis]. / Fotokhimicheskaia generatsiia kation-radikala bakteriohkhlorofilla b fotosinteziruiushchikh bakteriaakh Rhodopseudomonas viridis

The mechanism of photochemical redox reaction of bacteriochlorophyll b, bacteriopheophitin b was studied. The oxidation of bacteriochlorophyll b was carried out in ethanole by means of p-benzoquinone. In ESR spectra the singlet line with delta H = 8.4 gs and g = 2.0025 corresponded to cation-radical. The changes within the region of 400-500 nm, 500-600 nm and the band with the maximum at 685 nm corresponded to cation-radical in the absorption spectra. Photoreduction of bacteriochlorophyll b and bacteriopheophitin b was carried out in triet containing phenilhydrosin. Anion-radicals of bacteriochlorophyll b and bacteriopheophitin b observed in the ESR spectra had singlet form with weak and superthin structure and correspondently with delta H = 10 gs, delta H = 12 gs. The spectrophotometric characteristics of the above pigments were obtained.