ABSTRACT
Periodontal and endodontic diseases are inflammatory responses leading to periodontal and pulpal tissue loss. Regenerative therapies aim to restore the lost structures to vitality and function. Various materials and treatments methods have been used such as bone grafts, guided tissue regeneration, enamel matrix derivatives, growth and differentiation factors, and stem cells. Although the current materials and methods demonstrated adequate clinical results, true and complete biological tissue regeneration is not yet attainable. The current article reviews chronologically the materials and methods used in periodontal and endodontic regeneration highlighting their clinical success and shortcomings, and discussing future directions in regenerative therapy.
Subject(s)
Bone Transplantation/methods , Dental Pulp Diseases/therapy , Guided Tissue Regeneration, Periodontal/methods , Periodontal Diseases/therapy , Dental Enamel Proteins/therapeutic use , Dental Pulp Diseases/physiopathology , Humans , Intercellular Signaling Peptides and Proteins/therapeutic use , Periodontal Diseases/physiopathologyABSTRACT
The work performed by researchers in regenerative endodontics and tissue engineering over the last decades has been superb; however, many questions remain to be answered. The basic biologic mechanisms must be elucidated that will allow the development of dental pulp and dentin in situ. Stress must be placed on the many questions that will lead to the design of effective, safe treatment options and therapies. This article discusses those questions, the answers to which may become the future of regenerative endodontics. The future remains bright, but proper support and patience are required.