[Intravenous thrombolytic therapy of ischemic stroke with the drug Revelisa in real clinical practice: results of the IVT-AIS-R study]. / Vnutrivennaya tromboliticheskaya terapiya ishemicheskogo insul'ta preparatom Reveliza v real'noi klinicheskoi praktike: rezul'taty issledovaniya IVT-AIS-R.

OBJECTIVE: Evaluation of the safety and effectiveness of thrombolytic therapy (TLT) with the drug Revelisa (alteplase) in patients with ischemic stroke (AI) in real clinical practice. MATERIAL AND METHODS: An open prospective multicenter non-interventional register study was conducted, which included 550 patients with AI - 259 (47.1%) women and 291 (52.9%) men; average age 67.7±12.6 years. All included patients underwent TLT with the drug Revelisa within 4.5 hours from the onset of the disease and, according to the protocol of reperfusion therapy of AI, clinical, instrumental and laboratory examinations were performed. Symptomatic hemorrhagic transformation (GT) was determined in accordance with the criteria of the ECASS 3 study. RESULTS: The majority of patients (95.8%) suffered from hypertension, 69.6% had chronic heart failure, 53.8% had coronary heart disease, 38.7% had various cardiac arrhythmias, 20.7% of patients suffered from type 2 diabetes mellitus. A day after TLT, an improvement of 4 points or more on the NIHSS scale was noted in 45% of patients. The average dynamics index on the NIHSS stroke scale after a day was -3.2±4.7 and -4.4±6.1 per 7 females (p<0.0001). GT of the lesion of the brain developed in 10.9% of cases, symptomatic GT was diagnosed in 12 (2.3%) patients. The hospital mortality rate was 12.7%. The proportion of patients with good functional recovery (0-2 points on the modified Rankin scale (mRS)) at discharge, on days 30 and 90 was 44.7%, 59.2% and 68.5%, respectively. CONCLUSION: Performing TLT with the drug Revelisa in patients with AI leads to a statistically significant regression of neurological symptoms. A significant proportion of patients achieve a favorable clinical outcome upon discharge from the hospital and in the long term. The obtained data on the efficacy and safety profile correlate with previously published register studies of alteplase in AI.

[Use of optical coherence tomography angiography in assessment in conjunctival vascular architecture in health and pathology]. / Vozmozhnosti opticheskoi kogerentnoi tomografii v angiorezhime v otsenke angioarkhitektoniki kon"yunktivy v norme i pri patologii.

PURPOSE: Investigation of the capabilities of anterior segment (AS) optical coherence tomography angiography (OCTA) in evaluation of conjunctival vascular architecture in healthy individuals and in various pathological conditions. MATERIAL AND METHODS: The study included 17 healthy volunteers (34 eyes; the control group) and 62 patients (68 eyes) with conjunctival lesions of various nature. All participants underwent AS-OCT and AS-OCTA with assessment of qualitative (vessels pattern, lumen, pathologic tortuosity) and quantitative parameters (vessel density (VD, %) in the lesion area). Mean VD (MVD) and local VD (LVD) were determined, as well as VD in perifocal tissues (PVD). RESULTS: OCTA scans in 8 conjunctival sectors showed mostly radial pattern of the vascular architecture, with vessel lumen remaining the same over their entire visible length. Larger-sized vessels in deeper conjunctival layers were discovered in most cases. The lowest VD value (33.3%) was registered in the superotemporal quadrant, and the highest (38.9%) - in the nasal. Tortuosity of the vessels with course disruption, uneven lumen over the length of the vessels and increase in VD were observed in the area of conjunctival lesions in all cases excluding congenital abnormalities, pingueculae and conjunctival melanocytic intraepithelial neoplasia. The malignant nature of the tumors was indicated by dense vessel distribution and difficulties for visualization of intravascular space, and confirmed by pathohistological analysis. An increase in the number of areas with a lace-like pattern was characteristic for melanomas, with mean VD of more than 50% in the most vascularized areas. CONCLUSION: AS-OCTA is an informative method for the visualization of vessels in healthy conjunctiva and in conjunctival pathology. Local VD in the lesion area should be measured when the vessels are unevenly distributed.

[Structural and functional features of peripheral vasculature in patients with glaucoma]. / Strukturno-funktsional'nye osobennosti perifericheskikh sosudov pri glaukome.

PURPOSE: To study the reactivity of the vascular endothelium and the elastic properties of the upper and lower extremities, and assess the vascular innervation effect of Cytoflavin in patients with stable and rapidly progressive primary open-angle glaucoma (POAG). MATERIAL AND METHODS: The study included 67 patients with POAG (mean age 66.3±1.5 years), among them 31 with stable and 36 with rapidly progressive glaucoma. During the first stage of the study, the reactivity of the vascular endothelium was assessed with reactive hyperemia test; the viscoelastic properties of the upper and lower extremities were evaluated using volumetric sphygmomanometry. For the second stage of the study, patients were divided into the main group (n=20) that received intravenous injections of 10 ml Cytoflavin with 200 ml of 5% glucose solution for 10 days and then 2 tablets twice a day for 60 days, and the control group (n=16). RESULTS: The function of the vascular endothelium was significantly reduced in patients with rapidly progressive POAG. Correlation analysis revealed a negative correlation between the flow-dependent vasodilation (FDV), and the duration of POAG and initial diameter of the brachial artery (r=0.5, p<0.05 and r=0.6, p<0.05, respectively). Pathological response of vessel endothelium was detected in 88% of patients with stable and 96% of patients with rapidly progressive POAG. Cytoflavin was found to have positive effects on the endothelium in patients with POAG. CONCLUSION: The obtained data can be used for identification of risk factors for rapid POAG progression and optimization of its treatment.

[Comparative assessment of the phytoncidity of woody plants in the selection of species for landscaping: the possibility of use in sanatorium-and-spa practice]. / Sravnitel'naya otsenka fitontsidnosti drevesnykh rastenii pri podbore vidov dlya ozeleneniya: vozmozhnosti ispol'zovaniya v sanatorno-kurortnoi praktike.

THE PURPOSE OF THIS STUDY: Is a comparative assessment of the phytoncidity of woody plants of different botanical families and genera and the selection of taxa with a pronounced, long-term, and universal antimicrobial effect for use in greening and landscape construction in sanatorium-resort practice. MATERIAL AND METHODS: The objects of research were 167 species, hybrids, and intraspecific forms of woody plants from 25 botanical families and 16 genera. Evaluation of phytoncidity was carried out using the method of treating streak inoculation of microbial test cultures with volatile emissions of leaves; gram-positive bacteria Staphylococcus epidermidis (ATCC 25923), gram-negative bacteria Escherichia coli (ATCC 25922) and yeast-like fungi Candida albicans (ATCC 10231). RESULTS: It was established that woody plants of different taxonomic affiliations differ in the degree of antimicrobial activity, most of the studied taxa are characterized by seasonal variation of the studied trait. It was revealed that 102 (61.1%) of the species, form and hybrid are distinguished by pronounced activity to yeast-like fungi C. albicans, 64 (38.3%) - to E. coli and 33 (19.7%) - to bacteria St. epidermidis. The highest antimicrobial activity was recorded in representatives of the genera Salix, Populus, Amelanchier, Prinsepia, Prunus, Rosa, Spiraea, Picea, Pinus, Thuja, Juniperus, Caragana, Acer, Syringa. CONCLUSION: Based on the data obtained, 54 species, a hybrids, and a forms with a pronounced antimicrobial effect were identified, 21 with a long-lasting and 5 with a universal effect. The results can be used for landscaping resort and health areas in the Siberian region.

[Possibilities of ultrasound methods in diagnostics of eyelid tumors]. / Vozmozhnosti ul'trazvukovykh metodov issledovaniya v diagnostike novoobrazovanii vek.

PURPOSE: To determine the informative value of ultrasound biomicroscopy (UBM) with A-scan for assessment of qualitative and quantitative characteristics of eyelid tumors less than 5 mm in size. MATERIAL AND METHODS: The study included 25 patients (25 eyes) with eyelid tumors less than 5 mm in size. In addition to standard ophthalmic examination, complex ultrasound diagnostics including B-scan, Color Doppler imaging and UBM with A-scan were performed. The localization, size, structure of eyelid tumors and the state of perifocal tissues were evaluated. All patients underwent surgical treatment with following histological examinations of dissected tissues. Due to qualitative analysis of the studied formations and small number of included patients, there was no need in statistical analysis of the data. RESULTS: Complex application of UBM and A-scan allowed specifying the localization, size, structure of the small-sized tumors and detecting typical echographic signs of benign or malignant properties of the pathological process. Ultrasound data (UBM and A-scan) of eyelid tumors was highly correlated to histological features. CONCLUSION: UBM with A-scan can be recommended for differential diagnostics of small-sized tumors and optimizing their management.

[Bilateral occlusion of retinal vessels in Waldenstrom's disease (a case study)]. / Dvustoronniaia okkliuziia retinal'nykh sosudov pri bolezni Val'denstrema (klinicheskoe nabliudenie).

The article describes a clinical case of bilateral occlusion of retinal vessels in a patient with Waldenstrom's disease - a rare lymphoplasmocytic tumor of the bone marrow characterized by a complex of syndromes, among which the syndrome of blood hyperviscosity dominates. Comprehensive clinical, instrumental and laboratory examinations revealed that besides the syndrome of blood hyperviscosity the patient also had loci of cerebral ischemia (according to magnetic resonance imaging), ocular hypoperfusion with severe deficiency of retinal and choroidal blood flow (according to Doppler methods) indicating the presence of ocular ischemic syndrome. Since bilateral occlusion of retinal vessels without concomitant vascular and/or systemic pathology is rare, patients with such diagnosis should be referred to a hematologist.

Morphological Changes in the Retina Under Conditions of Experimental In Vivo Regional Ischemia/Reperfusion.

Two models of retinal ischemia/reperfusion were developed in an experiment on rats and structural changes in eye tissues in the early and late postischemic periods were studied. Ischemia/reperfusion was modeled by elevation of intraocular pressure to 110 mm Hg for 30 min with air injection into the anterior chamber of the eye with a special device or subconjunctival administration of 0.2 ml 4×10-6 M endothelin-1. Morphological studies of the retina of enucleated eyes were performed in 3, 7, and 30 days after ischemia/reperfusion. In 3 days, signs of retinal ischemia were seen (retinal edema and ganglion cell damage). In the late post-ischemic period (30 days), atrophy of the outer nuclear and outer plexiform layer of the retina was observed in animals with retinal ischemia/reperfusion caused by intraocular pressure elevation and complete destruction of neuronal cells was found after administration of endothelin-1.

[Impact of antiangiogenic therapy on ocular blood flow and microcirculation in diabetic macular edema]. / Vliianie antiangiogennoi terapii na glaznoi krovotok i mikrotsirkuliatsiiu pri diabeticheskom makuliarnom oteke.

Today, diabetic macular edema (DME) is still one of the main causes of vision loss in patients with diabetes. PURPOSE: To identify changes in the ocular blood flow and microvascular network of the macular zone in patients with DME after antiangiogenic therapy. MATERIAL AND METHODS: In the course of the study, 25 patients (50 eyes) with monolateral clinically significant DME aged 67.5±3.85 years were examined. Control group consisted of 75 healthy subjects (150 eyes). All patients underwent ultrasound examination of the eyes and orbits (in Color Doppler Imaging (CDI) and Pulse-Doppler modes) and OCT-angiography (OCT-A) before the intravitreal injection of ranibizumab, as well as 3 days, 2 weeks, and 1 month after the treatment. RESULTS: According to OCT-A, the initial values of microvascular network parameters were significantly below the norm (p<0.05). After intravitreal ranibizumab injection (IRI), no significant changes in the density of microcapillaries or in the parameters of foveal avascular zone (FAZ) were recorded. However, a transient increase of the FAZ area was revealed 2 weeks after the injection, as well as an increase of microcapillaries density in the central quadrant together with a decrease of density in the peripheral quadrants 1 month after IRI. By the end of the follow-up period, a decrease in the initially raised maximum systolic velocity (Vsyst) and resistance index (RI) in the ophthalmic artery (OA) of the affected eye were documented. Additionally, an increase in Vsyst and 2-fold increase in end-diastolic velocity (Vdiast), as well as a decrease in RI in the central retinal artery (CRA) on the affected and paired eyes were detected. CONCLUSION: The study revealed no negative effects of the angiogenesis inhibitor ranibizumab on retinal microcirculation or ocular blood flow. The registered changes in blood flow may indicate improvement of hemodynamic parameters after resorption of macular edema.

[The prospective of using plant polyphenols as functional food ingredients].

In this review we briefly discuss the publications dedicated to experimental evaluation of hypoglycemic, hypolipidemic and antioxidant properties of different plant polyphenols. The stages of preclinical studies of their efficacy are presented: in silico studies with molecular docking methods and in vivo studies with the use of genetic and medicamental models of type 2 diabetes. The results of own studies present the substantiation of prospects of using the plant polyphenol extracts as functional food ingredients for diet therapy and treatment of patients with type 2 diabetes. It was shown using genetic fatty Zucker rats model that extract consumption led to lower blood glucose level, had beneficial effect on glucose sensitivity and also improved the reaction of insulin-sensitive tissues on exogenous injection of glucose and insulin. Hypoglycemic and hypolipidemic properties of bilberry leaves extract were characterized on male Wistar rats model of carbohydrate metabolism disorder (streptozotocin injection accompanied with consumption of 10% fructose solution). The results of previous studies showed the beneficial effects of bilberry leaves extract on carbohydrate metabolism and determined the task to enhance the efficacy of developed polyphenol ingredient by the way of sorption on protein food matrix - brown buckwheat flour. Thus, a brief review of presented in this article results of foreign and domestic experimental studies shows the prospect of using the individual plant polyphenols and polyphenol plant extracts as phytonutrients for diet therapy and treatment of diseases associated with disorders of carbohydrate and lipid metabolism.

Genetic diversity and genomic signatures of selection among cattle breeds from Siberia, eastern and northern Europe.

Domestication in the near eastern region had a major impact on the gene pool of humpless taurine cattle (Bos taurus). As a result of subsequent natural and artificial selection, hundreds of different breeds have evolved, displaying a broad range of phenotypic traits. Here, 10 Eurasian B. taurus breeds from different biogeographic and production conditions, which exhibit different demographic histories and have been under artificial selection at various intensities, were investigated using the Illumina BovineSNP50 panel to understand their genetic diversity and population structure. In addition, we scanned genomes from eight breeds for signatures of diversifying selection. Our population structure analysis indicated six distinct breed groups, the most divergent being the Yakutian cattle from Siberia. Selection signals were shared (experimental P-value < 0.01) with more than four breeds on chromosomes 6, 7, 13, 16 and 22. The strongest selection signals in the Yakutian cattle were found on chromosomes 7 and 21, where a miRNA gene and genes related to immune system processes are respectively located. In general, genomic regions indicating selection overlapped with known QTL associated with milk production (e.g. on chromosome 19), reproduction (e.g. on chromosome 24) and meat quality (e.g. on chromosome 7). The selection map created in this study shows that native cattle breeds and their genetic resources represent unique material for future breeding.

[Clinical and anatomical features of congenital microphthalmia and anophthalmia in children and conservative methods of rehabilitation]. / Kliniko-anatomicheskie osobennosti vrozhdennogo mikroftal'ma i anoftal'ma u detei i konservativnye metody reabilitatsii.

AIM: To develop a comprehensive classification system of distinctive clinical and anatomical features of congenital microphthalmia and anophthalmia in children and to specify indications, contraindications, and optimal timing of the primary and subsequent prosthetic treatment. MATERIAL AND METHODS: A total of 70 patients with congenital micro- or anophthalmia aged from 1 month to 12 years were examined. Besides the routine ophthalmic examination, all patients underwent eye and orbit ultrasound (axial length measurement and B-scan), computed tomography of the orbits and skull, and immunological tests for infectious diseases (enzyme-linked immunosorbent assays). RESULTS: Basing on the examination RESULTS: we have determined the common types of congenital micro- and anophthalmia in children. We have also developed a stepwise prosthetic treatment aimed at better cosmetic rehabilitation. Indications and contraindications for the use of ocular prostheses in children with congenital micro- and anophthalmia have been identified. CONCLUSION: The proposed method of stepwise prosthetics is the principal option for conservative rehabilitation of children with congenital micro- or anophthalmia.

[Assessing resveratrol effect on ocular blood flow in experiment].

AIM: To study the effect of resveratrol on ocular blood flow in vivo in healthy rats and those that underwent retinal ischemia/reperfusion. MATERIAL AND METHODS: The experimental study was performed on 40 Wistar rats (40 eyes). For ocular blood flow evaluation, color Doppler imaging (CDI), power Doppler (PD), and pulsed-wave spectral Doppler ultrasonography were performed using the Voluson E8 Expert ultrasonic diagnostic system (GE Healthcare). All rats were given resveratrol per os for 2 months of the study. Retinal ischemia/reperfusion injury was induced by a subconjunctival injection of endothelin-1. The control group included 10 intact animals. RESULTS: Signs of ischemic damage of the anterior and posterior eye segments were less pronounced in rats that were given resveratrol during both pre-ischemic (30 days) and post-ischemic (30 days) periods of follow-up. There was also a statistically significant increase in the peak systolic and end diastolic velocity of blood flow as well as a decrease in the resistive index of retrobulbar arteries in those rats that underwent ischemia/reperfusion as compared to the controls. CONCLUSION: Long-term resveratrol use (2 months) has proved effective in improving ocular blood flow in a rat model of retinal ischemia/reperfusion injury.

[The First Russian Consensus on the Multilevel Abobotulinumtoxin A Injections in Spastic Forms of Cerebral Palsy]. / Pervyi Rossiiskii konsensus po primeneniyu mnogourovnevykh in''ektsii abobotulinumtoxin A pri lechenii spasticheskikh form detskogo tserebral'nogo paralicha.

Spasticity treatment is one of the key aspects of the contemporary cerebral palsy (CP) rehabilitation that influences on the effectiveness of other methods. The paper presents the first Russian document that unites the recommendations for the BTA treatment of CP and could be used as the guideline for the multilevel injections. The Russian consensus on the multilevel botulinum toxin A (BTA) treatment of spastic CP is based on the international data and the results of national studies. The authors describe typical CP spasticity patterns in the upper and lower extremities, give recommended intervals for the BTA (Abobotulinum toxin A) dosages for the whole injection procedure and for the separate muscles. The method of dosage calculation for functional segments is also described. Attention is paid to the frequency, optimal intervals between the repeated injections and the whole duration of BTA treatment. The authors discuss effectiveness and safety of BTA, factors that potentially influence the results of the injections, including ultrasound and electromyography control, and indications for the continuation and termination of treatment.

[Promising source of micronutrients for specialized foods with modified carbohydrate profile: traditional medicine experience].

Worldwide experience of Traditional medicine (TM) has been successfully applied to the development of modern standardized herbal medicines. Mainly researchers are guided by local sources of medicinal plants and traditional medical systems. TM experience is also used in the search of plants considered as sources of biologically active substances (BAS) and food ingredients. The steady increase in the incidence of type 2 diabetes, makes clear the need for research of domestic plant sources of BAS (with a proven carbohydrate metabolism effect) to create modern specialized foods. This article proves the feasibility of using TM experience of Russia and some neighboring European countries (Belarus, Ukraine) to develop optimized compositions for specialized food products for patients with type 2 diabetes. For reliable identification of the most promising plants, 550 traditional antidiabetic herbal formulations of 66 traditional recipe directories were studied in Russia, Belarus and Ukraine. It revealed 37 species of plants included to more than 20% of all bibliographical sources, and 13 plants included to more than 50% of prescription directories. The 3 most popular are bilberry leaves, leaffruit of common bean, great nettle leaves.

CHOLESTASIS OF PREGNANCY.

The article presents data concerning the prevalence, clinical manifestations, methods of diagnostics, treatment and prevention of cholestasis of pregnancy, as well as the case management depending on the gestation and the cholestasis severity. A clinical case of a typical course of cholesrasis of pregnancy is presented.

PANCREATITIS IN PREGNANCY: CASE MANAGMENT.

The purpose of the review is to summarise the current data on chronic and acute pancreatitis with the goal to improve the diagnostics and treatment of women during pregnancy, which complicates differential diagnosis of hepatopancreatobiliary system pathology. The features of the incidence, etiology, parhogenesis and evaluation of the severity of the clinical manifestations of acute pancreatitis in pregnant women are given, It is emphasis that the most frequent its reason is the gallstones following by the biliary pancreatitis. The experience of use in pregnant patients imaging methods - endoscopic ultrasound, magnetic resonance cholangiopancrearography and endoscopic retrograde cholangiopancreatography, as well as treatments that include endoscopic sphincterotomy, stone extraction from the common bile duct and laparoscopic cholecystectomy. The recommendations are based on expert opinions and are not supported by randomized controlled trials. Nevertheless more active clinical management allows to diagnose and treat effectively pancreatitis, including biliary etiology, which contributes to a sharp decline in maternal and perinatal mortality.

[The role of the food industry in dietetic therapy of the population. Specialized confectionery diabetic food].

Diabetes mellitus is a serious health and social problem of modernity, which in the future will increase and experts predict that the number of patients in 2030 will exceed 438,4 million. Taking into account the seriousness of the problem, and the fact that diabetes hurts an increasing number of young adults, the problem of creating diabetic food products, the positive effect of which on the organism is confirmed by experimental and clinical studies, is very relevant. The overview briefly covers information about the role of diet and ways to modify the composition and formulations of confectionery products of industrial production. The results of industry work towards the development of diabetic confectionery products in Russian Federation and peculiarities of their production and implementation in the framework of the Customs Union countries are summarized. Monitoring of the information entered in the register of specialized food products has been carried out, the lack of common approaches and tools in regulation imposed on the diabetic products in Russia, Belarus and Kazakhstan has been revealed. The necessity of objective regulatory impact assessment has been established. Its results will form the basis of the development of a unified approach to the production, handling and identification of diabetic confectionery and of the introduction of the General principle in relation to the probative value of the data, confirming their quality and safety. To improve the quality of population life and to reduce losses from socially significant diseases is possible through the development of personalized diets and their filling with products with attractive sensory properties. These data indicate the need for training highly qualified specialists with interdisciplinary knowledge in the field of food technology, nutrition and medicine.

[Ocular blood flow and retinal electrogenesis in retinitis pigmentosa].

AIM: to investigate correlations between changes in ocular hemodynamics revealed by color Doppler flow mapping (CDFM) and pulsed-wave (PW) Doppler imaging, one the one hand, and electrical activity of the retina, on the other, in patients with early, moderate, and severe retinitis pigmentosa (RP). MATERIAL AND METHODS: A total of 20 patients (40 eyes) aged from 16 to 40 years (28.4 ± 8.2 years on average) with retinitis pigmentosa were enrolled. The control group consisted of 20 healthy volunteers of the same age range. All participants underwent full-field electroretinography (ERG), flicker ERG, and macular ERG as well as blood flow assessment in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (SPCA) by means of CDFM and PW-Doppler. RESULTS: Ocular blood flow in CRA and SPCA appeared disturbed in patients with early RP. In cases of moderate and severe RP, the peak systolic velocity of CRA and SPCA blood flow was significantly decreased. Systolic and end diastolic blood flow velocities in CRA and SPCA has been shown to be directly related to full-field ERG a-wave and b-wave amplitudes, correspondingly, but negatively correlated with their implicit times. CONCLUSION: The revealed decrease in CRA and SPCA blood flow indices proves retinal and choroidal circulation deficit in patients with advanced RP. As shown, moderate blood flow changes are already present in early RP and progress as retinal photoreceptors and bipolar cells become suppressed, which may be useful for RP diagnosis and monitoring.

[Ultrasonography in normal eyelids assessment].

The article presents the results of a complex study on ultrasonography which included high-resolution grey scale B-scan, color Doppler imaging, and ultrasonic density measurement of eyelids and periorbital tissues. A total of 48 patients were enrolled. Echographic anatomy of eyelid layers, i.e. skin, orbicularis oculi muscle, tarsus, and orbital fat, is described in detail. Depth and ultrasonic density values for all layers are provided. The authors suggest performing an ultrasound examination of eyelids prior to reconstructive and plastic surgery in order to facilitate the choice of surgical tactics.

[The results of carotid endarterectomy in patients with carotid arteries stenosis and chronic ischemic optical neuropathy].

It was estimated an efficiency of surgical and conservative treatment of patients with atherosclerotic carotid arteries stenosis and chronic ischemic optical neuropathy. The first group included 30 patients after carotid endarterectomy. The second group included 20 patients who underwent conservative treatment. The methods of investigation included determination of visual acuity, autorefractometry, direct and inverse ophthalmoscopy under mydriasis, computer static perimetry, assessment of functional status of optic nerve by using of threshold of electric sensitivity and lability, ultrasonic scanning of eyes arteries and carotid arteries. Follow-up terms were baseline, in one month and in one year after surgery or conservative treatment. Improvement of visual acuity on 0.1 and more in 1st/2nd groups was 9/2 (p=0.1629), in one year - 12/1 (p=0.0075). Improvement of field of vision: in 1 month in 1st/2nd groups it was 12/3 (p=0.0692), in 1 year - 17/1 (p=0.0002). The dynamics of neurological status: there was equal ratio of asymptomatic/symptomatic patients at baseline in subgroups. In the 1st group it was 19/11 vs. 16/4 in the 2nd group (p=0.3451). In 1 year after two kinds of treatment significant changes were revealed. There was 26/4 in the 1st group vs. 13/7 in the 2nd group (p=0.0902) with improvement only after carotid endarterectomy - 19/11 at baseline vs. 26/4 in 1 year (p=0.0716). Insignificant deterioration was diagnosed after conservative treatment - 16/4 vs. 13/7 (p=0.4801).