ABSTRACT
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Subject(s)
Humans , Drug Hypersensitivity/diagnosis , Etodolac/adverse effects , Skin Diseases, Vesiculobullous/chemically induced , Cyclooxygenase 2 Inhibitors/adverse effectsSubject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Cyclooxygenase 2 Inhibitors/adverse effects , Drug Eruptions/diagnosis , Eosinophils/immunology , Epidermis/pathology , Etodolac/adverse effects , Lymphocytes/immunology , Adult , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Autoantibodies/blood , Cyclooxygenase 2 Inhibitors/administration & dosage , Drug Eruptions/immunology , Epidermis/drug effects , Epidermis/immunology , Etodolac/administration & dosage , Humans , Male , Thyroid Gland/immunology , Withholding TreatmentABSTRACT
BACKGROUND: Allergic rhinitis (AR) is a common chronic condition with significant consequences if left untreated (e.g., poor health outcomes, disease progression, and increased health care costs). However, about half of all patients do not fill their prescription.The factors associated with adherence are complex, and many remain poorly defined and understood. OBJECTIVES: This pilot study had 2 objectives. First, to determine whether the medication adherence report scale (MARS) can be applied to identify adherence/nonadherence in patients with AR using patients with chronic obstructive pulmonary disease (COPD) as controls. Second, to identify AR profiles that indicate a particularly high risk of nonadherence. METHODS: AR patients completed the Eysenck Personality Questionnaire-Revised Abbreviated-Form (EPQR-A), the Short Form 36 Health Survey (SF-36), the Mini Rhinitis Quality of Life Questionnaire (Mini-RQLQ), and the MARS. Symptom severity was assessed before and after treatment. RESULTS: The study population comprised 85 AR patients and 50 COPD patients. Females had worse adherence (significant only in total and unintentional scores) and higher extraversion scores. None of the personality traits predicted adherence. Neuroticism was negatively correlated with the SF-36 score (P < .001). A low to moderate correlation was observed between posttreatment improvement in specific/ generic health-related quality of life and MARS scores in AR patients (P = .002, r = 0.332; and P = .022, r = -0.251; respectively). Higher educational level was found to significantly increase adherence (P = .01, r = 0.223). CONCLUSIONS: Our study did not reveal a personality effect. However, it did suggest that use of a brief, self-completed medication adherence questionnaire in daily practice can enable health professionals to identify suboptimal adherence in patients who would benefit from close follow-up.
Subject(s)
Medication Adherence , Rhinitis, Allergic, Perennial/drug therapy , Adult , Female , Humans , Male , Middle Aged , Personality , Pilot Projects , Rhinitis, Allergic , Rhinitis, Allergic, Perennial/psychologyABSTRACT
Antecedentes: La rinitis alérgica (RA) constituye una condición crónica común que tiene consecuencias significativas, tales como una disminución del estado de salud, una progresión de la enfermedad y un incremento en el coste sanitario si no se trata. Aproximadamente la mitad de los pacientes con esta patología no se aplican el tratamiento recomendado. Los factores asociados a la adherencia al tratamiento son complejos, muchos están pobremente definidos y no son bien conocidos. Objetivo: El objetivo de este estudio piloto fue, en primer lugar, investigar si una escala para analizar la adherencia al tratamiento (MARS) podría ser utilizada para identificar esta condición en pacientes con rinitis alérgica en comparación con la enfermedad pulmonar obstructiva crónica como control. El segundo objetivo fue identificar el perfil de los pacientes con RA, especialmente de aquellos con alto riesgo de no adherencia al tratamiento. Métodos: Se aplicó el cuestionario Eysenck Personality Questionnaire-Revised Abbreviated-Form (EPQR-A), Short Form 36 Health-Survey (SF-36), Mini-Rhinitis Quality-of-Life Questionnaire (Mini-RQLQ), MARS. La gravedad de los síntomas se evaluó antes y después del tratamiento. Resultados: Fueron incluidos en el estudio 85 pacientes con RA y 50 con enfermedad pulmonar obstructiva crónica. En los resultados obtenidos, aunque las mujeres presentaban una menor adherencia (la cual fue únicamente significativa en los scores total y unidireccional), ninguno de los rasgos de personalidad analizados pudo predecir esta falta de adherencia. El neurotismo se correlacionó negativamente con el SF-36 (p<0.001). La mejoría postratamiento en el HRQoL específico/genérico se correlacionó moderadamente con los scores del MARS en los pacientes con RA (p=0.002, r=0.332 y p=0.022, r=-0.251; respectivamente). Un alto nivel de educación se correlacionó significativamente con un incremento en la adherencia al tratamiento (r=0.223, p=0.01). Conclusiones: Este primer estudio que evalúa la asociación entre adherencia al tratamiento y rasgos de personalidad en pacientes con RA no obtiene resultados que confirmen dicha asociación. Sin embargo, un dato de gran interés es que la aplicación de un simple cuestionario de adherencia a la medicación puede beneficiar el seguimiento de estos pacientes con RA por el clínico en la práctica clínica diaria (AU)
Background: Allergic rhinitis (AR) is a common chronic condition with significant consequences if left untreated (eg, poor health outcomes, disease progression, and increased health care costs). However, about half of all patients do not fill their prescription. The factors associated with adherence are complex, and many remain poorly defined and understood. Objectives: This pilot study had 2 objectives. First, to determine whether the medication adherence report scale (MARS) can be applied to identify adherence/nonadherence in patients with AR using patients with chronic obstructive pulmonary disease (COPD) as controls. Second, to identify AR profiles that indicate a particularly high risk of nonadherence. Methods: AR patients completed the Eysenck Personality Questionnaire-Revised Abbreviated-Form (EPQR-A), the Short Form 36 Health Survey (SF-36), the Mini Rhinitis Quality of Life Questionnaire (Mini-RQLQ), and the MARS. Symptom severity was assessed before and after treatment. Results: The study population comprised 85 AR patients and 50 COPD patients. Females had worse adherence (significant only in total and unintentional scores) and higher extraversion scores. None of the personality traits predicted adherence. Neuroticism was negatively correlated with the SF-36 score (P<.001). A low to moderate correlation was observed between posttreatment improvement in specific/generic health-related quality of life and MARS scores in AR patients (P=.002, r=0.332; and P=.022, r=0.251; respectively). Higher educational level was found to significantly increase adherence (P=.01, r=0.223). Conclusions: Our study did not reveal a personality effect. However, it did suggest that use of a brief, self-completed medication adherence questionnaire in daily practice can enable health professionals to identify suboptimal adherence in patients who would benefit from close follow-up (AU)
