[Efficacy and safety of surgical treatment of patients with pathological tortuosity of the internal carotid artery]. / Effektivnost' i bezopasnost' khirurgicheskogo lecheniya bol'nykh s patologicheskoi izvitost'yu vnutrennei sonnoi arterii.

No multicenter randomized clinical trial has been conducted worldwide to date on indications, types of surgery and their comparison with conservative treatment in patients with PI BSA. OBJECTIVE: Of the study is to improve the results of surgical treatment in patients with pathological tortuosity of the internal carotid artery. MATERIAL AND METHODS: The study included 119 patients (41 (34%) men and 78 (66%) women) with PI ICA aged 34 to 71 years (average age 53.2±7.5 years) divided into 2 groups. 64 patients (54%) of group I underwent BSA resection with lower mouth and 55 patients (46%) of group II underwent BSA prosthetics. Depending on the degree of neurological disorders, patients were distributed according to the classification of A.V. Pokrovsky. RESULTS: In the early postoperative period, TIA was noted in one patient, and transient lesions of the cranial nerves were observed in 5 patients. During 5 years of follow-up, none of the patients developed TIA, IS or other vascular events. In the early surgical period, there were no significant differences in effectiveness between the groups of patients. In the long-term period (5 years after surgery), a higher frequency of asymptomatic patients was noted in group I. CONCLUSION: Resection and replacement of a pathologically tortuous internal carotid artery (ICA) is a safe and effective surgical treatment. A multicenter randomized trial should be conducted to compare the effectiveness of surgical treatment of PI ICA with a conservative approach to effectively treat patients.

[Surgical treatment of internal carotid artery kinking following fibromuscular dysplasia]. / Rezul'taty khirurgicheskogo lecheniya patologicheskoi izvitosti vnutrennei sonnoi arterii na fone fibrozno-myshechnoi displazii.

OBJECTIVE: To evaluate the results of surgical treatment of internal carotid artery kinking following fibromuscular dysplasia. MATERIAL AND METHODS: There were 32 patients who underwent surgical treatment of internal carotid artery kinking following fibromuscular dysplasia. Structural changes of carotid artery wall were analyzed using immunohistochemical survey. Considering destructive changes revealed, we divided all patients into 2 groups in order to assess long-term postoperative outcomes: 1 - ICA resection followed by anastomosis in end-to-end fashion; 2 - ICA replacement. Postoperative analysis included incidence of stroke, thrombosis and deformities of anastomosis zone, regression of cerebrovascular insufficiency. RESULTS: The main «phenotype¼ of arterial wall in patients with ICA kinking following fibromuscular dysplasia is a large number of smooth muscle cells releasing matrix matelloproteinases-2 and -9 and low level of their tissue inhibitor type 1. Postoperative deformities are more common within a year after surgery. Maximum incidence is observed after 12 months. Both ICA resection and replacement are followed by similar incidence of deformity later. No severe deformities were diagnosed. Resection of ICA kinking on the background of fibromuscular dysplasia is followed by comparable results with ICA replacement regarding the incidence stroke, thrombosis and regression of cerebrovascular insufficiency. CONCLUSION: Despite degradation of extracellular matrix, destruction of elastic fibers and their fragmentation, no significant deformities are observed in long-term postoperative period in patients with ICA kinking and fibromuscular dysplasia.

[Results of surgical treatment of patients with internal carotid artery kinking depending on methods of its reconstruction].

It was analyzed the results of surgical treatment of 60 patients with internal carotid artery kinking operated in the department of vascular surgery of acad. B.V. Petrovsky Russian Scientific Center of Surgery of RAN. Indications for surgery included symptoms of cerebrovascular insufficiency (CVI) and instrumentally confirmed hemodynamically significant kinking of ICA. Criteria for surgical treatment were linear flow velocity gradient more than 2 and turbulent blood flow in the kinking segment diagnosed by ultrasonic scanning. All patients were divided into 2 groups depending on methods of surgery. The first group included 36 (60%) patients who underwent resection of ICA with orifice bringing down. The second group included 8 (13%) patients after ICA replacement and 16 (27%) cases with eversion endarterectomy, resection of ICA and orifice bringing down. The analysis of immediate surgery results did not reveal significant differences in dynamics of CVI and velocity parameters in reconstructed ICA (p>0.05). The index "stroke+mortality from stroke" was higher in the second group (p<0.05). Thrombosis of ICA reconstruction area has been developing more frequent (p<0.05) after ICA replacement (8%) in comparison with resection of ICA with orifice bringing down (0) and eversion endarterectomy, resection of ICA and orifice bringing down (0). Our data show that resection of ICA with orifice bringing down is preferable for surgical treatment of ICA kinking. ICA replacement is associated with significantly more frequent complications. Eversion endarterectomy with resection of ICA is optimal in case of combination of kinking with stenosis of ICA.

[Prevention of ischemic stroke in patients with asymptomatic lesions of carotid arteries].

Based on the data from both Russian and foreign literature, analysed herein are the methods of surgical and medicamentous prevention of ischaemic stroke in patients presenting with asymptomatic lesions of carotid arteries. This is followed by discussing haemodynamic parameters of the blood flow in the carotid arteries and their effect on cerebrovascular symptomatology. Also presented herein are the data concerning efficacy of different modalities of antithrombocytic therapy, followed by presenting own results regarding surgical management for stenoses and pathological kinking of carotid arteries in the patient cohort concerned.

[About the advantages of endovenous laser coagulation of subcutaneous veins].

From February 2007 to March 2010 42 operations concerning the varicose vein disease of lower limbs with magistral valvate inefficiency at the stage of chronic venous insufficiency with the usage of endophleboid laser congelation were performed in clinical outpatient conditions. Diode lasers with wave-length 980 nm. The period of temporary disablement was 14,5 days, after the standard combined phlebectomy with cirsotome--19,5 days. The complications after endophleboid laser congelation in the form of hematomas, burns, sense shock, thrombophlebitis weren't recorded.