ABSTRACT
We report a 12-year-old child with multiple autoimmune components consisting of minimal change nephrotic syndrome (MCNS), Hashimoto's thyroiditis and vitiligo. This boy presented with MCNS, complicated by acute renal failure, and subsequently developed Hashimoto's thyroiditis and vitiligo. Conventional prednisone treatment did not induce remission, but multiple high dose infusions of methylprednisolone led to remission. The occurrence of nephrotic syndrome, Hashimoto's thyroiditis and vitiligo suggests that similar immunological mechanisms may be involved in the pathogenesis of these diseases.
Subject(s)
Nephrosis, Lipoid/complications , Thyroiditis, Autoimmune/complications , Vitiligo/complications , Acute Kidney Injury/etiology , Child , Dose-Response Relationship, Drug , Humans , Infusions, Intravenous , Male , Methylprednisolone/administration & dosage , Methylprednisolone/therapeutic use , Nephrosis, Lipoid/drug therapy , Remission Induction , Thyroiditis, Autoimmune/drug therapy , Vitiligo/drug therapyABSTRACT
A case of erythroleukemia (EL; FAB M6) is presented in which the leukemic cells of the marrow were characterized by two ranges in the chromosome number, i.e., one hypodiploid and another near-tetraploid. All characteristics of major karyotypic abnormalities (MAKA) were present, i.e., increased karyotype instability with variation of the chromosome count from metaphase to metaphase, dicentrics, acentrics, marker chromosomes, double minute chromosomes (DMs), and centromere spreading. All of these events were variably represented from metaphase to metaphase. The prognosis was poor, with survival of 1 month after the diagnosis of EL. The meaning of extreme MAKA in the classification of EL is discussed.