[Analysis of the status of excess heart age and its risk factors among residents aged 35 to 64 years in China].

Objective: To analyze the status of excess heart age and its risk factors among Chinese residents aged 35 to 64 years. Methods: The study subjects were Chinese residents aged 35 to 64 years who completed the heart age assessment by WeChat official account "Heart Strengthening Action" through the internet from January 2018 to April 2021. Information such as age, gender, body mass index (BMI), blood pressure, total cholesterol (TC), smoking history, and diabetes history was collected. The heart age and excess heart age were calculated according to the characteristics of individual cardiovascular risk factors and the heart aging was defined as excess heart age≥5 years and 10 years respectively. The heart age and standardization rate were calculated respectively based on the population standardization of the 7th census in 2021.CA trend test was used to analyze the changing trend of excess heart age rate and population attributable risk (PAR) was used to calculate the contribution of risk factors. Results: The mean age of 429 047 subjects was (49.25±8.66) years. The male accounted for 51.17% (219 558/429 047) and the excess heart age was 7.00 (0.00, 11.00) years. The excess heart age rate defined by excess heart age≥5 years and ≥10 years was 57.02% (the standardized rate was 56.83%) and 38.02% (the standardized rate was 37.88%) respectively. With the increase of the age and number of risk factors, the excess heart age rate of the two definitions showed an upward trend according to the result of the trend test analysis (P<0.001). The top two risk factors of the PAR for excess heart age were overweight or obese and smoking. Among them, the male was smoking and overweight or obese, while the female was overweight or obese and having hypercholesterolemia. Conclusion: The excess heart age rate is high in Chinese residents aged 35 to 64 years and the contribution of overweight or obese, smoking and having hypercholesterolemia ranks high.

[Implementing the strategy of 'Healthy China' and strengthening the setting-up of National Demonstration Areas, for Comprehensive Prevention and Control of Non-communicable Diseases].

The former Ministry of Health launched a project regarding National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases (NCDs) in 2010. This study combined quantitative and qualitative methods, using epidemiological, anthropological and sociological methods to carry out process assessment, effectiveness and case study to evaluate the outcomes of the Demonstration Areas in China. A government leading body, under multi-sectoral cooperation pattern set for prevention and control of NCDs in the Demonstration Areas, was established. All the health related indicators of the residents from the NCDs appeared better than the national average level, showing the fact that the first phase goal on the establishment of Demonstration Areas was materialized. Papers that included in this issue "Evaluation on China National Demonstration Areas for NCDs Prevention and Control" elaborated the implementation status and effectiveness of the Demonstration Areas. It was our hope to provide reference for scaling up the Demonstration Areas and dynamic management in the future.

Comparison of the after discharges induced by electrical stimulation of the prefrontal cortex in urethane- and ketamine-anesthetized mice.

OBJECTIVE: The study aims to compare the effects of urethane and ketamine anesthesia on kindling-induced after discharges (AD). MATERIALS AND METHODS: We divided forty 4-6 week old female C57BL/6J mice into two groups: one group was anesthetized with urethane (n = 20) and the other with ketamine (n = 20). Kindling was with an electrical stimulation (ES) consisting of a 1-s pulse train of 60 1-ms biphasic pulses at an initial intensity of 700 µA, delivered to the pre-frontal cortex every minute. Ten to fifteen minutes after the first AD was induced, identical electrical stimuli were delivered every 10 minutes for 200 minutes. EEG was continuously recorded from 15 minutes before the first ES until 10 minutes after the last ES. The EEG wave spectrum was analyzed by Fast Fourier Transform and the power spectrum densities (PSDs) of the δ, θ, α, ß and γ bands were calculated. EEG wave amplitude was assessed using the root mean square value (RMS). RESULTS: In the urethane group, an initial AD was induced in 70% of mice following 39 ES. In the ketamine group, an initial AD was induced in 60% of mice following 74 ES. The changes in EEG spectra were similar in both groups. Pre-AD, EEG waves predominantly consisted of δ and θ components. During AD, γ and ß components increased significantly (p < 0.05). Post-AD, ß and γ components decreased and the δ: θ ratio increased to pre-AD levels. CONCLUSIONS: Our data suggest that AD can be induced by kindling stimulation of the pre-frontal cortex in mice under either urethane or ketamine anesthesia.