ABSTRACT
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in community acquired pneumonia (CAP) patients. We aimed to investigate the characteristics and mortality risk factors of COPD patients hospitalized with CAP. METHODS: A retrospective cohort study was conducted at Shanghai Pulmonary Hospital and Shanghai Dahua Hospital. Clinical and demographic data in patients diagnosed with CAP were collected between January 2015 and June 2016. Logistic regression analysis was performed to screen mortality risk factors of COPD patients hospitalized with CAP. RESULTS: Of the total 520 CAP patients, 230 (44.2%) patients had been diagnosed comorbid with COPD (COPD-CAP). CAP patients comorbid with COPD patients had higher rate of need for ICU admission (18.3% vs 13.1%) and need for NIMV (26.1% vs 1.4%) than without COPD (nCOPD-CAP). The PSI, CURB-65 and APACHE-II scores in COPD-CAP patients were higher than that in nCOPD-CAP patients (95 vs 79, P < 0.001; 1 vs 1, P < 0.001; 13 vs 8, P < 0.001, respectively). Logistic regression analysis indicated that aspiration, D-dimer > 2.0 µg/mL and CURB-65 ≥ 3 were risk factors associated with in-hospital mortality ((odd ratio) OR = 5.678, OR = 4.268, OR = 20.764, respectively) in COPD-CAP patients. The risk factors associated with 60-day mortality in COPD-CAP patients were comorbid with coronary heart disease, aspiration, need for NIMV (non-invasive mechanical ventilation) and CURB-65 ≥ 3 (OR = 5.206, OR = 7.921, OR = 3.974, OR = 18.002, respectively). CONCLUSIONS: COPD patients hospitalized with CAP had higher rate of need for NIMV, need for ICU admission and severity scores than those without COPD. Aspiration, D-dimer > 2.0 µg/mL, comorbid with coronary heart disease, need for NIMV and CURB-65 ≥ 3 were mortality risk factors in CAP patients comorbid with COPD.
Subject(s)
Coronary Disease/mortality , Fibrin Fibrinogen Degradation Products/metabolism , Pneumonia/mortality , Pulmonary Disease, Chronic Obstructive/mortality , Respiratory Aspiration/mortality , Aged , Aged, 80 and over , China/epidemiology , Community-Acquired Infections/blood , Community-Acquired Infections/mortality , Comorbidity , Female , Health Status , Hospital Mortality , Humans , Male , Noninvasive Ventilation , Pneumonia/blood , Pulmonary Disease, Chronic Obstructive/blood , Pulmonary Disease, Chronic Obstructive/therapy , ROC Curve , Retrospective Studies , Risk FactorsABSTRACT
Studies have demonstrated the changes of the physiological characteristics of nucleus accumbens (NAc) neurons with the postnatal development of rats. In the present study, spontaneous excitatory postsynaptic currents (sEPSCs) were recorded in the slices of NAc shell (NAcS) of adult and juvenile rats. Our results demonstrate that both the average amplitude of sEPSCs and the average frequency of sEPSCs in the NAcS slices of adult rats decreased significantly than that in juvenile rats. The average half width of sEPSCs in the NAcS slices in adult rats increased significantly than that in juvenile rats. The rise time of sEPSCs, the rise 50 time of sEPSCs and the 10-90 rise time of sEPSCs in the NAcS slices increased significantly in adult rats than that in juvenile rats. The decay time of sEPSCs in the NAcS slices also increased significantly in adult rats than that in juvenile rats. The above results strongly indicate that there are marked changes in the electrophysiological properties of single sEPSC in the NAcS slices of juvenile and adult rats.
