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1.
Dual effect of pyrilamine on absence seizures in WAG/Rij rats.
Midzyanovskaya, I; Kopilov, M; Fedotova, E; Kuznetsova, G; Tuomisto, L.
Inflamm Res ; 54 Suppl 1: S40-1, 2005 Apr.
Article in English | MEDLINE | ID: mdl-15928827

Subject(s)
Epilepsy, Absence/chemically induced , Epilepsy, Absence/physiopathology , Pyrilamine/pharmacology , Animals , Male , Rats , Seizures/chemically induced , Seizures/physiopathology
2.
Rat brain monoamines after acute and chronic myo-inositol treatment.
Einat, H; Belmaker, R H; Kopilov, M; Klein, E; Gazawi, H; Ben-Shachar, D.
Eur Neuropsychopharmacol ; 10(1): 27-30, 1999 Dec.
Article in English | MEDLINE | ID: mdl-10647093

ABSTRACT

Inositol was reported to have effects in depression, panic disorder and OCD, and in animal models of depression and anxiety. The present study tested whether inositol treatment alters monoamine systems. Brain areas of rats pre-treated with acute or chronic inositol were analysed by HPLC for monoamines and their metabolites and compared to control animals. Inositol treatment had no significant effect on levels of monoamines, their metabolites, or turnover rates compared to controls.


Subject(s)
Biogenic Monoamines/analysis , Brain Chemistry/drug effects , Inositol/administration & dosage , Administration, Oral , Animals , Chromatography, High Pressure Liquid , Corpus Striatum/chemistry , Corpus Striatum/drug effects , Frontal Lobe/chemistry , Frontal Lobe/drug effects , Hippocampus/chemistry , Hippocampus/drug effects , Hydroxyindoleacetic Acid/analysis , Injections, Intraperitoneal , Male , Mesencephalon/chemistry , Mesencephalon/drug effects , Rats , Rats, Sprague-Dawley , Time Factors
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