ABSTRACT
MRI-autopsy correlation in a case of gliomatosis cerebri suggests that poor gray-white matter demarcation on MRI may be sign of neoplastic infiltration. The extent of infiltration is imperfectly assessed by current imaging modalities.
Subject(s)
Astrocytoma/diagnosis , Brain Neoplasms/diagnosis , Magnetic Resonance Imaging , Tomography, X-Ray Computed , Adult , Astrocytoma/pathology , Basal Ganglia/pathology , Biopsy, Needle , Brain Neoplasms/pathology , Brain Stem/pathology , Cerebellum/pathology , Cerebral Cortex/pathology , Female , HumansABSTRACT
This investigation addresses the question of usefulness of computer-tomographic (CT) scanning in discriminating patients with Alzheimer's disease (AD) from healthy, aged controls. Quantitative measures of brain volume loss found to be significant by other investigators as well as additional unique variables are used to discriminate 58 longitudinally studied patients meeting NINCDS-ADRDA criteria for the clinical diagnosis of probable AD from 59 controls. The sensitivity and specificity of both single CT scan parameters and multivariate models comprised of such CT parameters are explored. Reasons for diagnostic misclassification are also illuminated.
Subject(s)
Alzheimer Disease/diagnostic imaging , Tomography, X-Ray Computed , Aged , Aged, 80 and over , Alzheimer Disease/diagnosis , Brain/diagnostic imaging , Diagnostic Errors , Evaluation Studies as Topic , Female , Humans , Longitudinal Studies , Male , Middle AgedABSTRACT
Descriptions of regenerating nodules of cirrhosis indicate that they are often isointense to liver parenchyma on magnetic resonance imaging (MRI). Regenerating nodules of cirrhosis can occasionally appear hypointense on all MRI sequences due to iron deposition within the nodules. We reviewed 21 cases of pathologically proven mixed or macronodular cirrhosis using MRI. In five patients, nodules appeared as hyperintense to liver parenchyma on short TR/TE images and were isointense on long TR/TE or GRASS images. In another five cases, nodules appeared hypointense on either long TR/TE or GRASS images, and corresponding hypointense nodules were observed on short TR/TE images in one of these patients. Our findings suggest that regenerating nodules of cirrhosis may have a more variable appearance on short TR/TE images.
Subject(s)
Liver Cirrhosis/diagnosis , Liver/pathology , Carcinoma, Hepatocellular/diagnosis , Humans , Liver Neoplasms/diagnosis , Liver Regeneration , Magnetic Resonance Imaging , Retrospective StudiesABSTRACT
A case of a 44-year-old woman with a solitary pulmonary coin lesion is presented. Histologic study of this nodule revealed a normal intraparenchymal pulmonary lymph node. A review of the literature discusses the incidence and characteristics of this entity.
