1.
J Biomol Tech
; 20(5): 253-7, 2009 Dec.
Article
in English
| MEDLINE
| ID: mdl-19949697
ABSTRACT
Identifying genetic variants and mutations that underlie human diseases requires development of robust, cost-effective tools for routine resequencing of regions of interest in the human genome. Here, we demonstrate that coupling Applied Biosystems SOLiD system-sequencing platform with microarray capture of targeted regions provides an efficient and robust method for high-coverage resequencing and polymorphism discovery in human protein-coding exons.