ABSTRACT
BACKGROUND: Treatment paradigms for Crohn's disease with perianal fistulae (CD-pAF) are evolving. AIMS: To study the impact of multimodality treatment in CD-pAF on recurrence rates and the need for re-interventions and to identify predictive factors for these outcomes. METHODS: This was a multinational multicentre retrospective cohort study. Multimodality approach was defined as using a combination of medical treatments (anti-TNFs ± immunomodulators ± antibiotics) along with surgical approach (examination under anaesthesia (EUA) ± seton drainage) at diagnosis of CD-pAF. Univariable and multivariable analyses were performed for variables indicative of the need for reintervention. RESULTS: A total of 253 patients were included. 65% of patients received multimodality approach. Multimodality treatment resulted in complete fistula healing in 52% of patients. Re-intervention was needed in 27% of patients with simple and in 40.3% of those with complex fistula. On multivariable analysis multimodality treatment (OR: 0.35, 95% CI: 0.17-0.57, P = 0.001), seton removal (OR: 0.090, 95% CI: 0.027-0.30, P = 0.0001, therapy with infliximab (OR: 0.19, 95% CI: 0.06-0.64, P = 0.007), and therapy with adalimumab (OR: 0.12, "95% CI: 0.026-0.56, P = 0.007) were predictive of avoiding repeat surgery. Proctitis (OR: 3.76, 95% CI: 1.09-12.96, P = 0.03) was predictive of the need for radical surgery (proctectomy, diverting stoma) while multimodality treatment reduced the need for radical surgery (OR: 0.21, 95% CI: 0.05-0.81, P = 0.02). CONCLUSIONS: Multimodality treatment, anti-TNFs use, and removal of setons after multimodality treatment can result in improved outcomes in CD patients with perianal fistulae and reduce the need for repeat surgery and radical surgery.
Subject(s)
Crohn Disease/drug therapy , Crohn Disease/surgery , Gastrointestinal Agents/therapeutic use , Rectal Fistula/drug therapy , Rectal Fistula/surgery , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Adalimumab/pharmacology , Adalimumab/therapeutic use , Adolescent , Adult , Aged , Aged, 80 and over , Cohort Studies , Combined Modality Therapy/methods , Crohn Disease/epidemiology , Drainage/methods , Female , Gastrointestinal Agents/pharmacology , Humans , Infliximab/pharmacology , Infliximab/therapeutic use , Internationality , Male , Middle Aged , Rectal Fistula/epidemiology , Retrospective Studies , Treatment Outcome , Wound Healing/drug effects , Wound Healing/physiology , Young AdultABSTRACT
BACKGROUND AND OBJECTIVE: Adrenal tissue-sparing or partial adrenalectomy evolved initially for patients with bilateral synchronous adrenal surgical pathology to preserve vital adrenal volume. In the laparoscopic era, the exact criteria for performing such procedures laparoscopically have yet to be defined. Controversy exists regarding the importance of preserving the adrenal vein, main or accessory. The aim of this retrospective study was to present our short series of laparoscopic tissue-sparing adrenalectomies with vein preservation. Our main goal is not to support partial adrenalectomy as an alternative to total (this is already advocated by many surgeons) but to emphasize the vein-preserving technique. METHODS: Seven patients with peripherally located either aldosterone-producing adenomas (4 cases) or myelolipomas (4 cases) underwent laparoscopic lateral partial adrenalectomy. One patient harbored an aldosterone-producing adenoma and a myelolipoma as well. The main adrenal vein was identified and preserved in 6 patients and the accessory vein in one. RESULTS: No conversion to open adrenalectomy was necessary, and no perioperative morbidity or mortality occurred. Three adenoma patients are normotensive 44, 23, and 20 months postoperatively, while the fourth one's pressure is refractory. CONCLUSIONS: Surprisingly, total adrenalectomies preceded the partial ones, which is controversial compared with other procedures. Laparoscopic lateral partial adrenalectomy is a technically challenging tissue-sparing operation. Meticulous dissection allows preservation of the middle artery and main or accessory vein resulting in a functioning adrenal stump.
Subject(s)
Adrenal Gland Neoplasms/surgery , Adrenal Glands/blood supply , Adrenalectomy/methods , Hyperaldosteronism/surgery , Laparoscopy , Myelolipoma/surgery , Veins/surgery , Adrenal Glands/surgery , Adult , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Time Factors , Treatment OutcomeABSTRACT
BACKGROUND AND OBJECTIVES: The majority of surgeons consider large and potentially malignant pheochromocytomas an absolute contraindication for laparoscopic adrenalectomy (LA). The aim of this study was to evaluate the risks and outcomes of LA in patients with this anomaly. METHODS: Five patients (2 males, 3 females) with large (>6 cm) pheochromocytomas were selected. Preoperative investigation demonstrated no evidence of invasive carcinoma. All patients received alpha-blocker preparation for at least 20 days. Laparoscopic adrenalectomy via a lateral transperitoneal approach was performed in all cases. RESULTS: Patient's median age was 48 years, and the median tumor size was 10.8 cm. No capsular disruption and no hypertensive crises occurred during the operation. The median operating time was 148 minutes and blood loss was <150 mL. Conversion to open adrenalectomy occurred in 2 patients owing to intraoperative evidence of carcinoma. No postoperative morbidity or mortality occurred. All patients are disease free after a median follow-up of 13 months. CONCLUSIONS: In experienced hands, LA can be proposed for large and potentially malignant pheochromocytomas. Conversion to open adrenalectomy is mandatory if local invasion, capsular disruption, or technical difficulties are observed during the operation.
