Subject(s)
Autoantibodies/blood , Celiac Disease/complications , Gliadin/immunology , Psoriasis/immunology , Female , Humans , MaleSubject(s)
Pemphigus , Pregnancy Complications , Adult , Female , Glucocorticoids/therapeutic use , Humans , Infant, Newborn , Methylprednisolone/therapeutic use , Pemphigus/diagnosis , Pemphigus/drug therapy , Pemphigus/immunology , Pregnancy , Pregnancy Complications/diagnosis , Pregnancy Complications/drug therapy , Pregnancy Complications/immunology , Retrospective StudiesSubject(s)
Telangiectasis/diagnosis , Urticaria Pigmentosa/diagnosis , Child , Female , Humans , Skin/pathologyABSTRACT
We report a 17-year-old male patient with erythromelanosis follicularis faciei et colli (EFFC), oral leucokeratosis and diabetes mellitus without islet cell antibody. His sister also had minimal findings of EFFC and minimal follicular papules on her shoulders and extensor surfaces of the arms. The father had only fine follicular papules, but no erythromelanosis. Skin and mucous membrane lesions of the proband were investigated histopathologically. Interestingly, in peripheral lymphocyte cultures of the family members, chromosomal breakage was not observed spontaneously, but it was seen with nitrogen mustard, although this disease may be of autosomal recessive inheritance. Thus, we suggest that EFFC may be a polyaetiological disorder (i.e. familial and environmental) and might be considered one of the chromosomal instability syndromes.
Subject(s)
Chromosome Aberrations/diagnosis , Darier Disease/genetics , Darier Disease/pathology , Erythema/genetics , Erythema/pathology , Hyperpigmentation/genetics , Hyperpigmentation/pathology , Adolescent , Chromosome Disorders , Darier Disease/complications , Diabetes Complications , Diabetes Mellitus/diagnosis , Erythema/complications , Humans , Hyperpigmentation/complications , Male , Prognosis , SyndromeABSTRACT
The efficacy, safety, required duration of treatment, and patient preference for oral fluconazole 150 mg/week in the treatment of 521 patients with cutaneous candidosis, tinea corporis, tinea cruris or tinea pedis were assessed in an open, multicentre, noncomparative trial. Patients received weekly doses of fluconazole 150mg for an average of 4.65 weeks. Cultures were examined microscopically at baseline, at 2-week intervals, at study end, and at long term follow-up (4 to 6 weeks after the last dose). All adverse events were recorded and rated; patients with laboratory findings outside normal values were monitored. Forms regarding patient preference for oral or topical medication type were assessed from 19 centres at study end. Clinical evaluation demonstrated an overall success rate (cure plus improvement) of 96% at the end of therapy, and 92% overall success rate at long term follow-up. Eradication of pathogens based on culture was equally high, with 92% eradicated at the end of therapy and 89% eradicated at long term follow-up. Patient tolerability was good; only 7 patients (1.3%) discontinued therapy because of adverse events, in 2 cases because of laboratory abnormalities. These findings suggest that oral fluconazole therapy is safe. This study demonstrated that weekly oral doses of fluconazole 150mg were effective in the treatment of tinea corporis, tinea cruris, tinea pedis and cutaneous candidosis. Furthermore, there was a high patient preference for oral fluconazole over previous topical therapy.
ABSTRACT
A double-blind study with terbinafine was performed in 39 patients with dermatophyte infection, between 1987 and 1989, to compare the safety and efficacy of two dosage schedules of 125 mg twice daily versus 250 mg once daily. Mycologic assessments were negative by microscopic examination and Sabouraud's culture in 59% and 100% of patients in the first and the fourth weeks of treatment, respectively. There was no statistically significant difference between the two groups of patients receiving 125 mg b.i.d. and 250 mg q.d. with respect to the safety and efficacy of the treatment; however, the differences between the sums of clinical scores before and after the treatment were statistically significant. There were no adverse effects, and the drug was well tolerated.
Subject(s)
Antifungal Agents/therapeutic use , Naphthalenes/therapeutic use , Tinea/drug therapy , Antifungal Agents/administration & dosage , Double-Blind Method , Drug Administration Schedule , Epidermophyton/isolation & purification , Female , Follow-Up Studies , Humans , Male , Naphthalenes/administration & dosage , Oxygenases/antagonists & inhibitors , Oxygenases/therapeutic use , Remission Induction , Terbinafine , Tinea/microbiology , Trichophyton/isolation & purificationABSTRACT
Follicular atrophoderma has been associated with a variety of findings. In our patient's family the disease was present in the mother and all of her living children. Scrotal tongue was also found in all but one child. We think that follicular atrophoderma is probably inherited as an autosomal dominant trait.
Subject(s)
Skin Diseases/genetics , Tongue, Fissured/complications , Adolescent , Adult , Atrophy , Child , Female , Humans , Male , Middle Aged , Skin Diseases/complications , Skin Diseases/pathology , Tongue, Fissured/geneticsSubject(s)
Microsporum/isolation & purification , Onychomycosis/microbiology , Child , Female , HumansABSTRACT
The epidemiology of scabies for the last twelve years has been studied in Turkey. Information was obtained from three regions (Istanbul, Ankara and Erzurum) having different climates. There has been an increase in scabies in the years following 1969 in Ankara and Erzurum and from 1967 on in Istanbul. It reached its maximum in 1978 in Erzurum, while this peak had been observed in early 1970s in other regions. Scabies incidence has significantly increased and decreased in winters and summers respectively, has been found to affect particularly the age group 15-44, and was observed more frequently in men than in women. Scabies seems to be moving to the eastern parts of Turkey.