[FUNCTIONAL CONDITION OF KIDNEYS IN NEWBORNS WITH CONGENITAL MALFORMATIONS IN THE PERIOPERATIVE PERIOD].

The article deals with results of the study of functional condition of kidneys in newborns with congenital surgical pathology in the perioperative period. Serum cystatin C and urine ß2-microglobulin were used as a marker of acute kidney injury (AKI). The evaluation of parameters was given in dynamics--before and after surgery, and on 1st, 5th and 10th postoperative day. We analyzed prospects of using these markers in the diagnosis of AKI.

[Hydrocephaly in newborns with perinatal brain damage of moderate severity].

A prospective examination of 103 newborns with hypoxic damage of the central nervous system of moderate severity was conducted on the 4-7, 10-14 and 21-28 days after birth and included clinical examination, neurosonographic study with dopplerography of great brain arteries and biochemical study of venous blood and urine. Children with ventriculomegalia were treated with diacarb. A control group included 15 newborns without signs of survived hypoxia. Ventriculomegalia was found in 29% of children in the main group and remained till the end of neonatal period in 15%, with moderate and large dilatation in 63,5% and mild dilatation of anterior horns of lateral ventriculars in 36,5%. The markers of development and long remaining ventriculomegalia are specified as follows: the morphofunctional immaturity of the brain (RR=1,7; 95%CI 1,16-2,45), absence of compensatory reduction of resistance index (RI) in anterior brain arteries on 4-7 days of life (RR=3,03; 95%CI 2,11-4,31), metabolic acidosis - the bicarbonate level in the venous blood less than 21 mmol/l (RR=2,9; 95% CI 1,66-5,02), carbanhydrase activation - bicarbonate concentration in the urine less than 5 mmol/mcmol of creatinine on 4-7 days of life (RR=3,81; 95%CI 2,87-5,02). Diacarb in ventriculomegalia should be prescribed only in case of disturbance of the organism compensatory reaction because it causes the significant increase of compensatory reduced RI. The drug has a nephrotoxic effect and causes metabolic acidosis.

[Urine medium weight molecules in assessment of the kidney status in newborns]. / Srednie molekuly mochi v otsenke sostoianiia pochek u novorozhdennykh.

The results of examinations of 66 newborns were used to suggest a new approach for evaluating the curves of medium urea molecules (calculations of the relative area beneath the curve and of areas of the first and second maxima). Issues related with the impact excreted by medication, endogenous intoxication and by a direct lesion to the renal tissues on a level of medium urea molecules are under discussion.

[High performance liquid chromatography and radioimmunoassay in analysis of serum hydrocortisone concentration and pharmacokinetic parameters of glucocorticoids in human. The choice of method for clinical practice]. / Vysokoéffektivnaia zhidkostnaia khromatografiia i radioimmunologicheskii analiz v opredelenii kontsentratsii kortizola i farmakokineticheskikh pokazatelei gliukokortikoidov v syvorotke krovi cheloveka. Vybor metoda v klinicheskoi praktike.

Serum hydrocortisone concentrations were measured by high performance liquid chromatography (HPLC) and radioimmunoassay (RIA) in 24 children with different diseases and 16 healthy adults. HPLC and RIA proved to be equally sensitive. However the authors recommend HPLC as a reliable, rapid, and ecologically pure method, which is, in addition, selective and economic.