ABSTRACT
The philosophy of the National Cancer Institute's (NCI) Cancer Information Service (CIS) staff training program is based on the premise that a solid relationship exists between staff performance and training. As a leading edge organization and the premiere cancer information service in the world, the CIS provides more training to its staff than many organizations. This factor is in part responsible for the program's success over the past 30 years, during which time the staff training program was revised to reflect a more comprehensive, performance-based approach. This paper describes the development of the curricula and the standards that are the foundation of the CIS program.
Subject(s)
Access to Information , Health Education , Information Services , National Institutes of Health (U.S.) , Neoplasms , Patient Education as Topic , Personnel Management , Program Development , Cooperative Behavior , Curriculum , Educational Status , Humans , Leadership , Learning , Program Evaluation , United StatesABSTRACT
A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT(6) receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT(6) receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.
Subject(s)
Oxazines/pharmacology , Receptors, Serotonin/drug effects , Serotonin Antagonists/pharmacology , Animals , Models, Chemical , Oxazines/chemical synthesis , Rats , Receptors, Serotonin/metabolism , Serotonin Antagonists/chemical synthesis , Structure-Activity RelationshipABSTRACT
This study addresses the Institute of Medicine's recommendation that AHRQ use MEPS data to identify a set of priority conditions to inform efforts at improving quality of care. Using MEPS data we identify the fifteen most expensive conditions in the U.S. in 1997: chronic diseases such as heart disease, cancer, and diabetes, and acute conditions such as trauma, pneumonia, and infectious disease. Comorbidities were also associated with increased expenses. Type-of-service and source-of-payment distributions varied considerably across this set of conditions. Our findings highlight some of the challenges likely to be encountered in efforts to reform the current system.
