ABSTRACT
The omental milky sports of the rat have been examined with the light and electron microscope after intraperitoneal stimulation by particulate coal and zymosan. No positive correlation between cell level proliferation in milky spots and alteration of their size has been found. The increase in size of milky spots is due to the inflow of cells from the blood and bone marrow. The development in milky spots of a great number of macrophages "tubercles" and multinucleated giant cells in the experimental conditions may respond to inflammation. The administration of zymosan result in the influx of lymphocytes forming lymphatic follicle-like structure. Despite the absence of germinative centres, the appearance of a great number of lymphoblasts and plasma cells in the milky spots provides the evidence of the active antibody production aimed at immunological protection of abdominal cavity.
Subject(s)
Connective Tissue/pathology , Macrophages , Omentum/pathology , Animals , Connective Tissue/immunology , Connective Tissue/ultrastructure , Male , Microscopy, Electron , Peritonitis/immunology , Peritonitis/pathology , Rats , Rats, Inbred StrainsABSTRACT
Experimental investigations (experiments in 61 dogs) have shown the application of drug occlusion on the gland duct system with cryodestruction of necrosis foci to be a promising method for treatment of pancreonecrosis.
Subject(s)
Cryosurgery , Embolization, Therapeutic/methods , Pancreas/pathology , Pancreatic Diseases/therapy , Pancreatic Ducts , Animals , Combined Modality Therapy , Dogs , Necrosis , Pancreatic Diseases/pathologyABSTRACT
The experience with modelling acute pancreatitis (AP) in dogs is summarized. In 15 of them, to reproduce AP, the intraductal administration of a bile with trypsin mixture was used, in 8--intraductal administration of automobile under the pressure, in 15--intraparenchymatous administration of automobile at several points. Depending on the method of modelling, the forms, rate and severity of the AP course were different.
Subject(s)
Disease Models, Animal , Pancreatitis/etiology , Acute Disease , Animals , Bile , Dogs , Necrosis , Pancreas/pathology , Pancreatic Ducts , Pancreatitis/pathology , Trypsin/administration & dosageSubject(s)
Pancreas/pathology , Pancreatic Ducts/drug effects , Pancreatitis/therapy , Animals , Atrophy/pathology , Carubicin/therapeutic use , Cyanoacrylates/therapeutic use , Dogs , Drug Evaluation, Preclinical , Necrosis , Pancreas/metabolism , Pancreatic Ducts/pathology , Pancreatitis/pathology , Time FactorsABSTRACT
The epithelium of mouse cornea and lymph nodes was examined for DNA-synthetic and mitotic activity at different times after thymectomy and administration of T-activin, an active factor of the thymus. Thymectomy entails retardation of the rate of corneal epithelium regeneration, diminution in both tissues under study of the amplitude of oscillations in cell proliferation throughout the day. Administration to the animals of the immunoactive thymic factor T-activin makes the circadian rhythm of cell proliferation return to normal. It is assumed that T-activin raises the capacity of lymphocytes to interact with epithelial cells, which manifests itself in the enhancement of their mitotic activity.