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Bioorg Med Chem Lett
; 23(10): 3070-4, 2013 May 15.
Article
in English
| MEDLINE
| ID: mdl-23562062
ABSTRACT
A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo animal models. The in vitro selectivity of 11p is also described.