Subject(s)
Databases, Chemical , Perfume/chemistry , Perfume/toxicity , Sesquiterpenes/analysis , Sesquiterpenes/toxicity , Animals , Consumer Product Safety , Drug Administration Routes , Endpoint Determination , Humans , No-Observed-Adverse-Effect Level , Perfume/administration & dosage , Risk Assessment , Sesquiterpenes/administration & dosage , Toxicity TestsABSTRACT
This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Subject(s)
Camphanes/analysis , Perfume/analysis , Valerates/analysis , Animals , Camphanes/toxicity , Chemistry/organization & administration , Consumer Product Safety , Databases, Chemical , Humans , Perfume/toxicity , Registries , Toxicity Tests , Valerates/toxicitySubject(s)
Camphanes/toxicity , Perfume/toxicity , Propionates/toxicity , Toxicity Tests/methods , Animals , Camphanes/chemistry , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Perfume/chemistry , Propionates/chemistry , Rats , Risk AssessmentSubject(s)
Cyclohexanes/toxicity , Perfume/toxicity , Toxicity Tests/methods , Animals , Consumer Product Safety , Cyclohexanes/chemistry , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentSubject(s)
Cyclohexanes/toxicity , Menthol/analogs & derivatives , Perfume/toxicity , Toxicity Tests/methods , Animals , Consumer Product Safety , Cyclohexane Monoterpenes , Cyclohexanes/chemistry , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , Menthol/chemistry , Menthol/toxicity , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentSubject(s)
Aldehydes/toxicity , Benzene Derivatives/toxicity , Perfume/toxicity , Toxicity Tests/methods , Aldehydes/chemistry , Animals , Benzene Derivatives/chemistry , Consumer Product Safety , DNA Damage/drug effects , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Endpoint Determination , No-Observed-Adverse-Effect Level , Perfume/chemistry , Rats , Risk AssessmentABSTRACT
: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).
