ABSTRACT
Nestin is a protein that belongs to a family of intermediate filament proteins which are typical for undifferentiated neural stem and progenitor cells. In this work nestin expression was studied in the hippocampus obtained from patients with epilepsy. Immunohistochemical investigation demonstrated five types of nestin-positive cells, differing in morphological and immunological phenotype. These included cell with a radial glia phenotype, bipolar cells, small dendritic cells, subependymal and astrocyte-like cells. Two types of these cells: radial glia of dentate gyrus and bipolar NG2+ cells can be considered as neural progenitor cells possessing different degrees of commitment.
Subject(s)
Epilepsy/metabolism , Hippocampus/metabolism , Intermediate Filament Proteins/metabolism , Nerve Tissue Proteins/metabolism , Antigens/metabolism , Epilepsy/pathology , Glial Fibrillary Acidic Protein/metabolism , Hippocampus/pathology , Humans , Immunohistochemistry , Nestin , Neuroglia/metabolism , Neurons/metabolism , Proteoglycans/metabolism , Vimentin/metabolismABSTRACT
Examinations of 46 patients with acute inflammatory diseases of the maxillofacial area revealed a reduction of some immunity parameters. Thymic activity of the saliva and blood was found to reduce still more after surgery (opening of the phlegmon). The ratio of thymic activities of the saliva and blood may be an indirect evidence of a tendency in development of an inflammatory process. The authors demonstrated the efficacy of correcting immunity parameters by tactivin, which was particularly effective in grave cases. Tactivin concentrations in the blood and saliva, their time course and ratio may be considered as additional criteria for assessing the status of patients and the risk of complications.
