NCA-GA-SVM: A new two-level feature selection method based on neighborhood component analysis and genetic algorithm in hepatocellular carcinoma fatality prognosis.

Hepatocellular carcinoma (HCC) is one of the major challenges facing biomedical research. Despite the high lethality, methods to predict mortality for this type of aggressive malignant tumor are insufficient. Machine learning is recognized by many authors as a valuable, yet poorly studied tool in this field. Undoubtedly, searching for new feature selection methods is significant in building an effective machine-learning model. In this study, we propose the novel hybrid model using neighborhood components analysis, genetic algorithm and support vector machine classifier (NCA-GA-SVM). Because SVM works with default parameters characterized by low classification results, we decided to use GA for the proper optimization and feature selection. As reported in the available literature, NCA and GA obtain high classification results. Here, we decided to combine these approaches, building a two-level algorithm for HCC fatality prognosis. We used a well-known dataset collected from 165 patients at Coimbra's Hospital and University Center, Portugal. Our results revealed 96.36% classification accuracy and 95.52% F1-score. Additionally, we compared all data for these metrics published so far. We demonstrated that our algorithm achieved the highest accuracy and can be successfully applied for the assessment of hepatocellular carcinoma mortality in the future. Our findings bring methodological value for future HCC studies and emphasize the possibility of using machine-learning techniques to improve the quality of medical decisions.

Transmission Quality Classification with Use of Fusion of Neural Network and Genetic Algorithm in Pay&Require Multi-Agent Managed Network.

Modern computer systems practically cannot function without a computer network. New concepts of data transmission are emerging, e.g., programmable networks. However, the development of computer networks entails the need for development in one more aspect, i.e., the quality of the data transmission through the network. The data transmission quality can be described using parameters, i.e., delay, bandwidth, packet loss ratio and jitter. On the basis of the obtained values, specialists are able to state how measured parameters impact on the overall quality of the provided service. Unfortunately, for a non-expert user, understanding of these parameters can be too complex. Hence, the problem of translation of the parameters describing the transmission quality appears understandable to the user. This article presents the concept of using Machine Learning (ML) to solve the above-mentioned problem, i.e., a dynamic classification of the measured parameters describing the transmission quality in a certain scale. Thanks to this approach, describing the quality will become less complex and more understandable for the user. To date, some studies have been conducted. Therefore, it was decided to use different approaches, i.e., fusion of a neural network (NN) and a genetic algorithm (GA). GA's were choosen for the selection of weights replacing the classic gradient descent algorithm. For learning purposes, 100 samples were obtained, each of which was described by four features and the label, which describes the quality. In the reasearch carried out so far, single classifiers and ensemble learning have been used. The current result compared to the previous ones is better. A relatively high quality of the classification was obtained when we have used 10-fold stratified cross-validation, i.e., SEN = 95% (overall accuracy). The incorrect classification was 5/100, which is a better result compared to previous studies.

Comparison of various approaches to combine logistic regression with genetic algorithms in survival prediction of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common liver cancer in adults. Many different factors make it difficult to diagnose in humans.. In this paper, a novel diagnostics approach based on machine learning techniques is presented. Logistic regression is one of the most classic machine learning models used to solve the problem of binary classification. In typical implementations, logistic regression coefficients are optimized using iterative methods. Additionally, parameters such as solver, C - a regularization parameter or the number of iterations of the algorithm operation should be selected. In our research, we propose a combination of logistic regression with genetic algorithms. We present three experiments showing the fusion of those methods. In the first experiment, we genetically select the logistic regression parameters, while the second experiment extends this approach by including a genetic selection of features. The third experiment presents a novel approach to train the logistic regression model - the genetic selection of coefficients (weights). Our models are tested for the survival prediction of hepatocellular carcinoma based on patient data collected at Coimbra's Hospital and Universitary Center (CHUC), Portugal. The model we proposed achieved a classification accuracy of 94.55% and an f1-score of 93.56%. Our algorithm shows that machine learning techniques optimized by the proposed concept can bring a new and accurate approach in HCC diagnosis with high accuracy.

Hyperspectral Classification of Blood-Like Substances Using Machine Learning Methods Combined with Genetic Algorithms in Transductive and Inductive Scenarios.

This study is focused on applying genetic algorithms (GAs) to model and band selection in hyperspectral image classification. We use a forensic-inspired data set of seven hyperspectral images with blood and five visually similar substances to test GA-optimised classifiers in two scenarios: when the training and test data come from the same image and when they come from different images, which is a more challenging task due to significant spectral differences. In our experiments, we compare GA with a classic model optimisation through a grid search. Our results show that GA-based model optimisation can reduce the number of bands and create an accurate classifier that outperforms the GS-based reference models, provided that, during model optimisation, it has access to examples similar to test data. We illustrate this with experiments highlighting the importance of a validation set.

A new machine learning technique for an accurate diagnosis of coronary artery disease.

BACKGROUND AND OBJECTIVE: Coronary artery disease (CAD) is one of the commonest diseases around the world. An early and accurate diagnosis of CAD allows a timely administration of appropriate treatment and helps to reduce the mortality. Herein, we describe an innovative machine learning methodology that enables an accurate detection of CAD and apply it to data collected from Iranian patients. METHODS: We first tested ten traditional machine learning algorithms, and then the three-best performing algorithms (three types of SVM) were used in the rest of the study. To improve the performance of these algorithms, a data preprocessing with normalization was carried out. Moreover, a genetic algorithm and particle swarm optimization, coupled with stratified 10-fold cross-validation, were used twice: for optimization of classifier parameters and for parallel selection of features. RESULTS: The presented approach enhanced the performance of all traditional machine learning algorithms used in this study. We also introduced a new optimization technique called N2Genetic optimizer (a new genetic training). Our experiments demonstrated that N2Genetic-nuSVM provided the accuracy of 93.08% and F1-score of 91.51% when predicting CAD outcomes among the patients included in a well-known Z-Alizadeh Sani dataset. These results are competitive and comparable to the best results in the field. CONCLUSIONS: We showed that machine-learning techniques optimized by the proposed approach, can lead to highly accurate models intended for both clinical and research use.