Initial Development and Validation of Physical Therapy-Patient Education Questionnaire (PT-PEQ).

BACKGROUND: Patient education can increase patient engagement and positive outcomes with physical therapy treatment. This study aimed to develop and evaluate the psychometric properties of a physical therapy patient education questionnaire. METHODS: Candidate items were developed and evaluated by an expert panel for content validity. The resulting items were administered to 350 patients in physical therapy treatment, and the reliability and validity of the scale's subscales were evaluated. RESULTS: The final version of the questionnaire consists of 36 items that assess six education domains for patients receiving physical therapy: 1) assessment and information provision (10 items), 2) hygiene and safety (9 items), 3) patient empowerment (8 items), 4) emergency and infection control (3 items), 5) adverse event prevention (4 items), and 6) identity confirmation (2 items). The internal consistency of the subscales ranged from 0.69 to 0.92, and support for the six-domain structure of the items was supported via factor analysis. CONCLUSIONS: The questionnaire was successfully developed and evidenced good psychometric properties for the assessment of the perceived importance of six physical therapy education domains. Research is needed to evaluate potential gaps between patients' perceived education needs and therapist education activities during physical therapy treatment.

The effect of a home-based stretching exercise on the ground reaction force generation and absorption during walking in individuals with plantar fasciitis.

OBJECTIVES: This study aimed to investigate effect of a home-based stretching exercise program in individuals with plantar fasciitis (PF) and to compare its effect on ground reaction force (GRF)-time variables between mild, moderate, and severe pain subgroups and between before and after in each subgroup. DESIGN: A single cohort with pre-and post-test. INTERVENTIONS: Twenty individuals with PF received 3 weeks of home-based stretching exercise for calf and plantar fascia. MAIN OUTCOME MEASURES: GRF-time variables included force and time at; first peak (F1 and TF1), valley (F2 and TF2), second peak (F3 and TF3) in vertical, breaking (F4 and TF4) and propulsive (F5 and TF5) forces, first peak (F6 and TF6) and second peak lateral (F7 and TF7) forces. Additionally, worst pain was assessed at before and after exercise. RESULTS: Significant reductions were seen in F2, TF2, TF3, TF5 and worst pain after exercise (P < 0.05) in individuals with PF. No differences were seen between three subgroups. For within subgroup analysis, only mild subgroup showed significant changes in F2, TF2, F4, TF6, and TF7 after exercise (P < 0.05). CONCLUSION: A home-based stretching exercise was effective in reducing pain and some GRF-time variables, with the most noticeable response seen in mild subgroup.

Physical activity on prescription in patients with hip or knee osteoarthritis: A randomized controlled trial.

OBJECTIVE: To evaluate whether physical activity on prescription, comprising five sessions, was more effective in increasing physical activity than a one-hour advice session after six months. DESIGN: Randomized, assessor-blinded, controlled trial. SETTING: Primary care. SUBJECTS: Patients with clinically verified osteoarthritis of the hip or knee who undertook less than 150 minute/week of moderate physical activity, and were aged 40-74 years. INTERVENTIONS: The advice group (n = 69) received a one-hour session with individually tailored advice about physical activity. The physical activity on prescription group (n = 72) received individually tailored physical activity recommendations with written prescription, and four follow-ups during six months. MAIN MEASURES: Patients were assessed at baseline and six months: physical activity (accelerometer, questionnaires); fitness (six-minute walk test, 30-second chair-stand test, maximal step-up test, one-leg rise test); pain after walking (VAS); symptoms (HOOS/KOOS); and health-related quality of life (EQ-5D). RESULTS: One hundred four patients had knee osteoarthritis, 102 were women, and mean age was 60.3 ± 8.3 years. Pain after walking decreased significantly more in the prescription group, from VAS 31 ± 22 to 18 ± 23. There was no other between groups difference. Both groups increased self-reported activity minutes significantly, from 105 (95% CI 75-120) to 165 (95% CI 135-218) minute/week in the prescription group versus 75 (95% CI 75-105) to 150 (95% CI 120-225) in the advice group. Also symptoms and quality of life improved significantly in both groups. CONCLUSION: Individually tailored physical activity with written prescription and four follow-ups does not materially improve physical activity level more than advice about osteoarthritis and physical activity. TRIAL REGISTRATION: ClinicalTrials.gov (NCT02387034).

Effect of a home-based stretching exercise on multi-segmental foot motion and clinical outcomes in patients with plantar fasciitis.

OBJECTIVES: This study aimed to investigate the effect of a home-based stretching exercise on multi-segmental foot motion and clinical outcomes in patients with plantar fasciitis (PF). METHODS: A single group pre- and post-test design was conducted for this study in 20 patients with PF. They had the self home-based stretching program of calf muscle for 3 weeks. They were assessed for the multi-segmental foot motion (degree) and clinical outcomes which included the plantar fascia pain/disability scale (PFPS) (score), muscle length (degree) of gastrocnemius and soleus, and muscle strength (kg) of ankle dorsiflexors, plantarflexors, invertors, evertors, great toe flexors, and lesser toe flexors. RESULTS: There were no significant differences (p>0.05) in multi-segmental foot motion and muscle length after exercise. Significant improvements (p<0.05) were found in PFPS and muscle strength of ankle plantarflexors, invertors, evertors, great toe flexors, and lesser toe flexors after exercise. CONCLUSIONS: A home-based stretching exercise was an effective program for reducing pain, enhancing muscle strength for both extrinsic and intrinsic foot muscles in patients with PF.

Adenosine monophosphate-activated protein kinase activation and suppression of inflammatory response by cell stretching in rabbit synovial fibroblasts.

Joint mobilization is known to be beneficial in osteoarthritis (OA) patients. This study aimed to investigate the effect of stretching on adenosine monophosphate-activated protein kinase (AMPK) activity and its role in modulating inflammation in rabbit synovial fibroblasts. Uniaxial stretching of isolated rabbit synovial fibroblasts for ten min was performed. Stretching-induced AMPK activation, its underlying mechanism, and its anti-inflammatory effect were investigated using Western blot. Static stretching at 20 % of initial length resulted in AMPK activation characterized by expression of phosphorylated AMPK and phosphorylated acetyl-Co A carboxylase. AMP-activated protein kinase phosphorylation peaked 1 h after stretching and declined toward resting activity. Using cell viability assays, static stretching did not appear to cause cellular damage. Activation of AMPK involves Ca2+ influx via a mechanosensitive L-type Ca2+ channel, which subsequently raises intracellular Ca2+ and activates AMPK via Ca2+/calmodulin-dependent protein kinase kinase ß (CaMKKß). Interestingly, stretching suppressed TNFα-induced expression of COX-2, iNOS, and phosphorylated NF-κB. These effects were prevented by pretreatment with compound C, an AMPK inhibitor. These results suggest that mechanical stretching suppressed inflammatory responses in synovial fibroblasts via a L-type Ca2+-channel-CaMKKß-AMPK-dependent pathway which may underlie joint mobilization's ability to alleviate OA symptoms.

Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study.

Synovial inflammation plays an important role in the early pathogenesis of osteoarthritis (OA). Chitosan oligosaccharide (COS) has been shown to activate AMPK and suppress inflammatory responses in intestinal epithelial cells. This study aimed to investigate the effect of COS on AMPK activation and synovial inflammation using both primary cultures of synoviocytes and a rabbit model of anterior cruciate ligament (ACL) transection-induced OA. COS induced AMPK activation in both rabbit and human synoviocytes. The mechanism of COS-induced AMPK activation involves an increase in the ADP/ATP ratio but not calcium/calmodulin-dependent protein kinase kinase beta (CaMKKß). Interestingly, COS suppressed the TNFα-induced iNOS and COX-2 expression via an AMPK-dependent mechanism in both rabbit and human synoviocytes. Importantly, oral administration of COS (10mg/kg/day) induced AMPK activation and alleviated signs of inflammation including COX-2 expression in the synovium of a rabbit ACL transection model. Taken together, our results indicate that COS suppresses synovial inflammation in vitro and in vivo via AMPK activation. COS may be useful in the prevention of OA.